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Pediatric B-Cell Lymphoma with Follicular Pattern and 11q Aberration

A case study of a 14-year-old boy with an enlarged cervical lymph node showing a vaguely follicular infiltrate with medium to large cells. Immunostaining patterns include CD20, CD3, IgD, MIB-1, CD10, BCL-6, MUM-1, and λK. Cytogenetic analysis revealed an 11q aberration, highlighting the diagnostic challenges and treatment considerations for aggressive B-cell lymphomas in pediatric patients.

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Pediatric B-Cell Lymphoma with Follicular Pattern and 11q Aberration

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  1. EAHP-16-LYWS-119 Aggressive B-cell lymphoma with a follicular pattern and 11q aberration Elaine S Jaffe*, Reiner Siebert, Rabea Wagener, Michael Hayes, Shilpa Shivakumar & Stefania Pittaluga * Presenting author

  2. Clinical History • 14-year-old boy, presented with 4-to-6-week history of an enlarged cervical lymph node.  No B symptoms. PET is negative. LDH was normal. BM aspirate was normal. CSF was consistently negative.

  3. Low power shows a vaguely follicular infiltrate

  4. Starry sky at low power

  5. Cells are medium to large in size, some variability

  6. CD20 shows follicular and diffuse pattern

  7. CD3 highlights interfollicular T-cells

  8. IgD MIB-1

  9. CD10 MIB-1

  10. BCL-6

  11. BCL-6 MUM-1

  12. λ K

  13. aCGH

  14. 11q-probe: CEP11/ Minimal gain region /minimal loss region Green signals >red signals

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