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The Mother and Child Cohort in Crete, Rhea Study

The Mother and Child Cohort in Crete, Rhea Study. Study design & key findings Leda Chatzi, MD, PhD Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece Brussels, October 2011.

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The Mother and Child Cohort in Crete, Rhea Study

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  1. The Mother and Child Cohort in Crete, Rhea Study Study design & key findings Leda Chatzi, MD, PhD Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece Brussels, October 2011

  2. The Mother & Child Cohort in Crete, Rhea Study Study protocol: pregnancy- 2 years of age 12w – 24w Pregnancy 25w – 36w Pregnancy 9th month 18th month 4th year Delivery 1st month Child Cord blood Q5 (parents) Q4 (parents) Neurodevelopment Mother FFQ Q2 +urine sample Q3 + blood sample EPDS Q 1 + blood + urine sample EPDS STAI-T EPQ S. Capital

  3. The Mother & Child Cohort in Crete, Rhea Study Study protocol: 4 years 4th year Clinical Exams Urine & Blood samples Neurodevelopment (McCarthy) Clinical Examination (+ spirometry) Questionnaires FFQ Physical activity Q Parenting Stress Index (PSI-SF) Q6 (Clinical Questionnaire) AD/HD Quest. Strengths & Difficulties Quest. (SDQ)

  4. The Mother & Child Cohort in Crete, Rhea Study Diet assessment in pregnancy • Dietary habits in mid pregnancy: FFQ on 250 items, completed by personal interview • Dietary changes during pregnancy: FFQ in 3rd trimester, 100 items, completed by personal interview • Supplement use: specific questions in mid, late pregnancy for supplement use, brand names, dosages. • Nutrient analysis:Based on the UK Nutrient Databank (McCance and Widdowson's, 6th edition 2002).

  5. The Mother & Child Cohort in Crete, Rhea Study Diet assessment in childhood • Breastfeeding practices: Questionnaire 9th month • Introduction of solid foods: Questionnaire 9th month • Dietary habits at 4 years: FFQ, 100 items, personal interview with the parents • Nutrient analysis:Based on the UK Nutrient Databank (McCance and Widdowson's, 6th edition 2002).

  6. The Mother & Child Cohort in Crete, Rhea Study The Greek Mother & Child Cohort Study • Biological samples, Clinical Measurements related to Maternal Obesity in pregnancy • Serum 10-14th week of gestation: Fasting glucose, TG, LDL, HDL, Tchol, insulin • Cord Blood at birth: Leptin • Maternal anthropometry: BMI pre-pregnancy; BMI- first trimester, weight gain during pregnancy • Blood pressure measurement:Standard protocol, 10-14th week of gestation • Definition of Metabolic syndrome: NCEP III criteria with some adaptations to our study population of pregnant women

  7. RHEA STUDY PIs Manolis Kogevinas Leda Chatzi Coordination Leda Chatzi Maria Vassilaki Antonis Koutis Biobank Eleni Fthenou Georgia Chalkiadaki Polly Karakosta Maria Sarri Chemistry Evripides Stephanou • Epidemiology • Theano Roumeliotaki • Katerina Sarri • Vaggelis Georgiou • Manolis Bagkeris • Vicky Patelarou • Constantinos Vardavas • Vicky Lebentakou Field Study S.Matalliotaki, D. Pagiataki, Μ. Karachaliou Κ. Koutra V.Lebentakou

  8. The Greek Mother & Child Cohort Study The Greek Mother & Child Cohort Study to be continued …………… Thank you…

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