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Authors: Kieu Vu, John Arend , Nichole Cadez , Deb Darnell, Valerie Somma ,

Enhancing Cancer Surveillance: Statewide Collection of Biomarkers and Prognostic Factors, Colorado’s Multi-phase Implementation. Authors: Kieu Vu, John Arend , Nichole Cadez , Deb Darnell, Valerie Somma , Randi Rycroft, Loria Pollack, Paran Pordell. Cancer Genomics Program

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Authors: Kieu Vu, John Arend , Nichole Cadez , Deb Darnell, Valerie Somma ,

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  1. Enhancing Cancer Surveillance: Statewide Collection of Biomarkers and Prognostic Factors, Colorado’s Multi-phase Implementation Authors: Kieu Vu, John Arend, Nichole Cadez, Deb Darnell, Valerie Somma, Randi Rycroft, Loria Pollack, ParanPordell

  2. Cancer Genomics Program -Bidirectional reporting for genetic counseling services -Uptake of universal testing • The Colorado Cancer Plan & Comprehensive Cancer Program • Advisory Committee • - Increase testing among individuals whose cancer treatment may benefit from targeted proven or emerging therapies CCCR Biomarker Project • Women’s Wellness Connection • BCCP (Triple negative breast cancer) • WISEWOMAN & CRC

  3. CCCR Biomarker Project • Colorado Law and Board of Health regulation allow flexibility for the CCCR to add new requirements & ability to access CORHIO/RMCC • Phase 1: review and case finding, create code sets, CO pages, 2018 documentation • Phase 2: 2019 coding

  4. Biomarker Data Sources Health Exchange Database [CORHIO] Hospitals Each hospital has their individual software Colorado Central Cancer Registry – RMCDS software Free Standing Cancer Centers or Physician Offices [Rocky Mountain Cancer Centers] Pathology Labs eMaRC

  5. CCCR codes using CAP/ SSDI/ NCCN CCCR Code set CAP SSDI

  6. MSI - colorectal, endometrium BRAF - colorectal, melanoma, thyroid ALK, EGFR, PD-L1, ROS1 -- late stage lung BIOMARKERS

  7. Examples of data from electronic exchange and hospital

  8. Biomarker data capture in the CCCR’s RMCDS

  9. Preliminary Results for Lung Cancer Biomarkers INSERT

  10. Preliminary Results for Thyroid Cancer Biomarkers INSERT

  11. Preliminary MSI results for CRC and Endometrium

  12. Challenges/Lessons learned Learning curve on NCCN guidelines/CAP protocols Insufficient detail on certain biomarkers (thyroid BRAF V600) 2018 delay Infrastructure OIT challenges eMaRC access RMCDS Biomarkers/Prognostic Factors are available and it is feasible to collect population-based biomarker data.

  13. NEXT STEPS Complete data collection Train hospital registrars Develop “report cards” Pilot report cards with hospitals

  14. Next Steps & Overall Process and Goals Train hospital registrars Develop “report cards” Complete data collection Pilot report cards with hospitals Choose Biomarkers CO Biomarker Requirements Design code sets Create codes in software Central registries can collect biomarker data on population level Monitor uptake of Universal testing Can the data improve clinical care? Monitor appropriate use of testing Data will improve ability to assign genetic risk

  15. Thank you –Questions and Contacts Kieu Vu kieu.vu@state.co.us 303.692.3475 John Arend john.arend@state.co.us 303.692.2542

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