Halobacterium sp. NRC-1 NP_045984

1. Halobacterium sp. NRC-1 NP_045984 Halobacterium sp. NRC-1 NP_046115 Halobacterium sp. NRC-1 NP_395927 Halobacterium sp. NRC-1 NP_395611 Halobacterium salinarum R1 YP_001690410 Halobacterium salinarum R1 YP_001690911 Saccharopolyspora erythraea NRRL 2338 YP_001105158 Nocardia farcinica IFM 10152 YP_117796 Mycobacterium smegmatis str. MC2 155 YP_889839 Frankia sp. EAN1pec YP_001510823 Frankia sp. CcI3 YP_479373 Frankia alni ACN14a YP_710879 Herpetosiphon aurantiacus ATCC 23779 YP_001545011 Symbiobacterium thermophilum IAM 14863 YP_075521 Gramella forsetii KT0803 YP_861002 Anaeromyxobacter dehalogenans 2CP-C YP_464151 Anaeromyxobacter sp. Fw109-5 YP_001378174 Myxococcus xanthus DK 1622 YP_635027 Sorangium cellulosum So ce 56 YP_001613076 Bacillus subtilis subsp. subtilis str. 168 NP_390949 Bacillus amyloliquefaciens FZB42 YP_001422361 Bacillus pumilus SAFR-032 YP_001487928 Bacillus licheniformis ATCC 14580 YP_080351 Bacillus licheniformis ATCC 14580 YP_092768 Bacillus halodurans C-125 NP_241744 Bacillus clausii KSM-K16 YP_174786 Bacillus cereus subsp. cytotoxis NVH 391-98 YP_001376946 Bacillus cereus ATCC 14579 NP_834887 Bacillus weihenstephanensis KBAB4 YP_001647789 Bacillus thuringiensis serovar konkukian str. 97-27 YP_039214 Bacillus anthracis str. Ames NP_847628 Bacillus thuringiensis str. Al Hakam YP_897414 Bacillus anthracis str. Sterne YP_031312 Bacillus anthracis str. Ames Ancestor YP_022123 Bacillus cereus E33L YP_086487 Bacillus cereus ATCC 10987 NP_981630 Picrophilus torridus DSM 9790 YP_023387 Picrophilus torridus DSM 9790 YP_023642 Thermoplasma volcanium GSS1 NP_110602 Thermoplasma acidophilum DSM 1728 NP_394935 Thermoplasma acidophilum DSM 1728 NP_394452 Thermoplasma volcanium GSS1 NP_111251 Exiguobacterium sibiricum 255-15 YP_001814487 Lysinibacillus sphaericus C3-41 YP_001695995 Bacillus halodurans C-125 NP_244843 Oceanobacillus iheyensis HTE831 NP_691971 Geobacillus kaustophilus HTA426 YP_147937 Geobacillus kaustophilus HTA426 YP_146457 Geobacillus thermodenitrificans NG80-2 YP_001124645 Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 YP_301795 Staphylococcus epidermidis ATCC 12228 NP_764339 Staphylococcus epidermidis RP62A YP_188257 Staphylococcus haemolyticus JCSC1435 YP_253784 Staphylococcus aureus subsp. aureus MRSA252 YP_040473 Staphylococcus aureus subsp. aureus JH1 YP_001316309 Staphylococcus aureus subsp. aureus str. Newman YP_001331986 Staphylococcus aureus subsp. aureus Mu3 YP_001441668 Staphylococcus aureus subsp. aureus USA300 YP_493684 Staphylococcus aureus subsp. aureus N315 NP_374205 Staphylococcus aureus subsp. aureus JH9 YP_001246522 Staphylococcus aureus subsp. aureus USA300 TCH1516 YP_001574927 Staphylococcus aureus subsp. aureus NCTC 8325 YP_499580 Staphylococcus aureus subsp. aureus MSSA476 YP_043145 Staphylococcus aureus subsp. aureus COL YP_185958 Staphylococcus aureus subsp. aureus Mu50 NP_371610 Staphylococcus aureus subsp. aureus MW2 NP_645785 Staphylococcus aureus RF122 YP_416437 Burkholderia vietnamiensis G4 YP_001116207 Syntrophobacter fumaroxidans MPOB YP_847118 Syntrophobacter fumaroxidans MPOB YP_847160 Anabaena variabilis ATCC 29413 YP_320073 Anabaena variabilis ATCC 29413 YP_324548 Synechococcus elongatus PCC 6301 YP_173035 Synechococcus elongatus PCC 7942 YP_400784 Gloeobacter violaceus PCC 7421 NP_924143 Cyanothece sp. ATCC 51142 YP_001804829 Anabaena variabilis ATCC 29413 YP_320076 Nostoc sp. PCC 7120 NP_488064 Anabaena variabilis ATCC 29413 YP_322192 Acaryochloris marina MBIC11017 YP_001520281 Synechocystis sp. PCC 6803 NP_440505 Thermosynechococcus elongatus BP-1 NP_682392 Synechococcus sp. JA-3-3Ab YP_475181 Synechococcus sp. JA-2-3Ba2-13 YP_477446 Bradyrhizobium japonicum USDA 110 NP_766923 Burkholderia multivorans ATCC 17616 YP_001585770 Azorhizobium caulinodans ORS 571 YP_001524270 Methylobacterium radiotolerans JCM 2831 YP_001757504 Hahella chejuensis KCTC 2396 YP_432017 Marinomonas sp. MWYL1 YP_001342988 Francisella philomiragia subsp. philomiragia ATCC 25017 YP_001677725 Francisella tularensis subsp. novicida U112 YP_899232 Francisella tularensis subsp. holarctica FTA YP_001429301 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 YP_094253 Legionella pneumophila str. Paris YP_122602 Legionella pneumophila str. Corby YP_001249616 Legionella pneumophila str. Lens YP_125621 Rhodopseudomonas palustris HaA2 YP_483827 Parvibaculum lavamentivorans DS-1 YP_001411876 Alcanivorax borkumensis SK2 YP_694142 Colwellia psychrerythraea 34H YP_270499 Saccharophagus degradans 2-40 YP_526702 Vibrio cholerae O1 biovar eltor str. N16961 NP_231211 Vibrio cholerae O395 YP_001217121 Methylibium petroleiphilum PM1 YP_001021761 Bradyrhizobium japonicum USDA 110 NP_770368 Bordetella petrii DSM 12804 YP_001629498 Bordetella parapertussis 12822 NP_885736 Bordetella bronchiseptica RB50 NP_890546 Bordetella pertussis Tohama I NP_881775 Chromobacterium violaceum ATCC 12472 NP_903328 Mesorhizobium loti MAFF303099 NP_105373 Jannaschia sp. CCS1 YP_508678 Dinoroseobacter shibae DFL 12 YP_001534022 Azoarcus sp. BH72 YP_933275 Ralstonia solanacearum GMI1000 NP_522803 Ralstonia metallidurans CH34 YP_587360 Polaromonas sp. JS666 YP_550908 Polaromonas naphthalenivorans CJ2 YP_980736 Halorhodospira halophila SL1 YP_001003985 Alkalilimnicola ehrlichei MLHE-1 YP_742877 Chromohalobacter salexigens DSM 3043 YP_574051 Marinobacter aquaeolei VT8 YP_958735 Mesorhizobium sp. BNC1 YP_676598 Xanthobacter autotrophicus Py2 YP_001416174 Ralstonia solanacearum GMI1000 NP_522768 Burkholderia vietnamiensis G4 YP_001115027 Burkholderia multivorans ATCC 17616 YP_001585473 Burkholderia pseudomallei 668 YP_001062961 Burkholderia pseudomallei 1106a YP_001075908 Burkholderia pseudomallei K96243 YP_111388 Methylobacterium extorquens PA1 YP_001639446 Methylobacterium sp. 4-46 YP_001768208 Xanthomonas campestris pv. campestris str. ATCC 33913 NP_638161 Xanthomonas campestris pv. campestris str. 8004 YP_242389 Xanthomonas axonopodis pv. citri str. 306 NP_643292 Xanthomonas campestris pv. vesicatoria str. 85-10 YP_364860 Xanthomonas oryzae pv. oryzae MAFF 311018 YP_450200 Xanthomonas oryzae pv. oryzae KACC10331 YP_199912 Xanthomonas campestris pv. campestris str. ATCC 33913 NP_639037 Xanthomonas campestris pv. campestris str. 8004 YP_244822 Xanthomonas axonopodis pv. citri str. 306 NP_644042 Xanthomonas campestris pv. vesicatoria str. 85-10 YP_365585 Xanthomonas oryzae pv. oryzae KACC10331 YP_199278 Xanthomonas oryzae pv. oryzae MAFF 311018 YP_449618 Psychrobacter arcticus 273-4 YP_264797 Psychrobacter cryohalolentis K5 YP_580955 Wolbachia endosymbiont of Drosophila melanogaster NP_966497 Rickettsia bellii RML369-C YP_537689 Rickettsia bellii OSU 85-389 YP_001496000 Rickettsia canadensis str. McKiel YP_001491977 Rickettsia felis URRWXCal2 YP_246349 Rickettsia akari str. Hartford YP_001493141 Rickettsia prowazekii str. Madrid E NP_220602 Rickettsia typhi str. Wilmington YP_067171 Rickettsia massiliae MTU5 YP_001499104 Rickettsia conorii str. Malish 7 NP_359925 Rickettsia rickettsii str. Sheila Smith YP_001494408 Rickettsia rickettsii str. Iowa YP_001649653 Idiomarina loihiensis L2TR YP_154434 Polynucleobacter sp. QLW-P1DMWA-1 YP_001156393 Granulibacter bethesdensis CGDNIH1 YP_743957 Zymomonas mobilis subsp. mobilis ZM4 YP_163306 Gluconobacter oxydans 621H YP_190717 Acidiphilium cryptum JF-5 YP_001235159 Enterobacter sakazakii ATCC BAA-894 YP_001439012 Xanthomonas campestris pv. campestris str. ATCC 33913 NP_638010 Xanthomonas campestris pv. campestris str. 8004 YP_242542 Nitrobacter hamburgensis X14 YP_571560 Methylobacterium extorquens PA1 YP_001641277 Methylobacterium radiotolerans JCM 2831 YP_001752902 Mesorhizobium sp. BNC1 YP_674974 Rhodospirillum rubrum ATCC 11170 YP_425651 Bradyrhizobium sp. ORS278 YP_001208645 Bradyrhizobium sp. BTAi1 YP_001236881 Rhodopseudomonas palustris BisB18 YP_529990 Rhodopseudomonas palustris BisA53 YP_779478 Rhodopseudomonas palustris CGA009 NP_950127 Rhodopseudomonas palustris HaA2 YP_488264 Rhodopseudomonas palustris BisB5 YP_571496 Methylobacterium sp. 4-46 YP_001771100 Methylobacterium radiotolerans JCM 2831 YP_001757570 Paracoccus denitrificans PD1222 YP_917772 Sphingomonas wittichii RW1 YP_001260922 Novosphingobium aromaticivorans DSM 12444 YP_496304 Sinorhizobium meliloti 1021 NP_384665 Sinorhizobium medicae WSM419 YP_001325865 Psychromonas ingrahamii 37 YP_943166 Roseobacter denitrificans OCh 114 YP_681157 Rhodobacter sphaeroides ATCC 17025 YP_001170018 Rhodobacter sphaeroides 2.4.1 YP_354730 Rhodobacter sphaeroides ATCC 17029 YP_001045802 Acinetobacter sp. ADP1 YP_046412 Acinetobacter baumannii ATCC 17978 YP_001084464 Acinetobacter baumannii AYE YP_001714068 Burkholderia xenovorans LB400 YP_557210 Burkholderia multivorans ATCC 17616 YP_001585362 Burkholderia ambifaria AMMD YP_777566 Burkholderia ambifaria MC40-6 YP_001816424 Burkholderia sp. 383 YP_366247 Burkholderia sp. 383 YP_366658 Burkholderia cenocepacia MC0-3 YP_001774662 Burkholderia cenocepacia AU 1054 YP_621301 Burkholderia cenocepacia HI2424 YP_840030 Burkholderia vietnamiensis G4 YP_001115242 Burkholderia xenovorans LB400 YP_553508 Burkholderia vietnamiensis G4 YP_001116102 Burkholderia multivorans ATCC 17616 YP_001583283 Burkholderia sp. 383 YP_370935 Burkholderia ambifaria AMMD YP_776701 Burkholderia ambifaria MC40-6 YP_001812025 Burkholderia cenocepacia AU 1054 YP_625229 Burkholderia cenocepacia HI2424 YP_839104 Burkholderia cenocepacia MC0-3 YP_001778411 Burkholderia thailandensis E264 YP_440336 Burkholderia pseudomallei 1710b YP_336927 Burkholderia mallei NCTC 10247 YP_001079272 Burkholderia mallei NCTC 10229 YP_001024930 Burkholderia pseudomallei 668 YP_001061434 Burkholderia mallei SAVP1 YP_990436 Burkholderia pseudomallei 1106a YP_001074378 Burkholderia pseudomallei K96243 YP_110254 Burkholderia mallei ATCC 23344 YP_106386 Marinomonas sp. MWYL1 YP_001341997 Ralstonia eutropha JMP134 YP_298301 Ralstonia eutropha H16 YP_840979 1000 Methylobacillus flagellatus KT YP_545052 Methylobacillus flagellatus KT YP_545196 1000 772 Bordetella parapertussis 12822 NP_883344 Bordetella bronchiseptica RB50 NP_887784 113 1000 Bordetella petrii DSM 12804 YP_001632445 112 Azoarcus sp. EbN1 YP_159652 536 184 Ralstonia metallidurans CH34 YP_587086 Ralstonia eutropha JMP134 YP_298481 Ralstonia eutropha H16 YP_840698 723 920 Pseudomonas putida GB-1 YP_001669500 9 Gluconacetobacter diazotrophicus PAl 5 YP_001600819 124 294 Azorhizobium caulinodans ORS 571 YP_001526675 419 Pseudomonas aeruginosa PA7 YP_001348478 Pseudomonas aeruginosa PA7 YP_001346562 449 Pseudomonas aeruginosa PAO1 NP_252619 1000 Pseudomonas aeruginosa UCBPP-PA14 YP_789187 751 Pseudomonas entomophila L48 YP_608020 279 Pseudomonas fluorescens Pf-5 YP_260833 739 Pseudomonas fluorescens PfO-1 YP_349115 628 Pseudomonas stutzeri A1501 YP_001172323 71 Pseudomonas mendocina ymP_YP_001186246 668 Pseudomonas fluorescens Pf-5 YP_262432 Pseudomonas syringae pv. phaseolicola 1448A YP_276457 363 Pseudomonas syringae pv. syringae B728a YP_237350 768 996 Pseudomonas syringae pv. tomato str. DC3000 NP_794399 802 Pseudomonas fluorescens PfO-1 YP_350621 319 Pseudomonas entomophila L48 YP_610218 Pseudomonas putida W619 YP_001747661 502 Pseudomonas putida KT2440 NP_746760 880 Pseudomonas putida F1 YP_001269817 961 1000 Pseudomonas putida GB-1 YP_001670867 543 Photorhabdus luminescens subsp. laumondii TTO1 NP_929304 Vibrio parahaemolyticus RIMD 2210633 NP_800647 326 Shewanella sp. MR-7 YP_737020 Shewanella sp. ANA-3 YP_868569 309 924 Shewanella baltica OS155 YP_001049308 1000 Shewanella baltica OS185 YP_001367639 Shewanella baltica OS195 YP_001555995 998 Shewanella sp. W3-18-1 YP_964615 428 572 696 Shewanella putrefaciens CN-32 YP_001182458 649 Yersinia enterocolitica subsp. enterocolitica 8081 YP_001006678 Serratia proteamaculans 568 YP_001479088 607 Citrobacter koseri ATCC BAA-895 YP_001452803 Enterobacter sp. 638 YP_001176857 432 Klebsiella pneumoniae subsp. pneumoniae MGH 78578 YP_001335591 589 686 Enterobacter sakazakii ATCC BAA-894 YP_001438025 Enterobacter sp. 638 YP_001177845 827 Klebsiella pneumoniae subsp. pneumoniae MGH 78578 YP_001334816 362 658 Salmonella enterica subsp. arizonae serovar 62 YP_001571562 Salmonella enterica subsp. enterica serovar Typhi str. CT18 NP_454955 273 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 NP_806232 1000 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 YP_215388 Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7 YP_001589431 946 Salmonella typhimurium LT2 NP_459355 553 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 YP_151558 706 Flavobacterium johnsoniae UW101 YP_001197197 Acidobacteria bacterium Ellin345 YP_592327 1000 Solibacter usitatus Ellin6076 YP_827888 785 Anaeromyxobacter sp. Fw109-5 YP_001378843 Rhodopirellula baltica SH 1 NP_869127 829 Candidatus Protochlamydia amoebophila UWE25 YP_008629 Chlamydia muridarum Nigg NP_296660 569 Chlamydia trachomatis D UW-3 CX NP_219515 Chlamydia trachomatis A HAR-13 YP_327811 1000 807 Chlamydia trachomatis 434 Bu YP_001654352 966 Chlamydia trachomatis L2b UCH-1 proctitis YP_001653364 822 970 Chlamydophila abortus S26 3 YP_220039 1000 Chlamydophila caviae GPIC NP_829534 853 Chlamydophila felis Fe C-56 YP_515258 622 Chlamydophila pneumoniae AR39 NP_445214 861 Chlamydophila pneumoniae TW-183 NP_876378 1000 Chlamydophila pneumoniae CWL029 NP_224310 108 Chlamydophila pneumoniae J138 NP_300162 738 Anaeromyxobacter dehalogenans 2CP-C YP_466933 348 Heliobacterium modesticaldum Ice1 YP_001680379 908 Carboxydothermus hydrogenoformans Z-2901 YP_361239 Aquifex aeolicus VF5 NP_213934 Syntrophus aciditrophicus SB YP_461912 Pelobacter carbinolicus DSM 2380 YP_358496 Geobacter sulfurreducens PCA NP_952691 682 Geobacter metallireducens GS-15 YP_384884 992 997 Geobacter uraniireducens Rf4 YP_001230923 Pelobacter propionicus DSM 2379 YP_900848 829 444 Syntrophobacter fumaroxidans MPOB YP_844474 Desulfococcus oleovorans Hxd3 YP_001530529 621 929 Lawsonia intracellularis PHE MN1-00 YP_594652 787 Desulfovibrio desulfuricans G20 YP_389693 1000 Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough YP_012481 946 Desulfovibrio vulgaris subsp. vulgaris DP4 YP_965569 1000 Symbiobacterium thermophilum IAM 14863 YP_074471 Methanosarcina acetivorans C2A NP_615957 Methanosarcina barkeri str. Fusaro YP_303687 712 1000 Bacillus cereus subsp. cytotoxis NVH 391-98 YP_001376669 792 846 Bacillus thuringiensis serovar konkukian str. 97-27 YP_038840 Bacillus cereus ATCC 10987 NP_981242 1000 436 Bacillus cereus E33L YP_086122 993 Bacillus cereus ATCC 14579 NP_834494 344 Bacillus weihenstephanensis KBAB4 YP_001647411 551 Bacillus anthracis str. Ames NP_847241 Bacillus anthracis str. Sterne YP_030934 492 Bacillus anthracis str. Ames Ancestor YP_021698 918 123 Bacillus thuringiensis str. Al Hakam YP_897070 711 Moorella thermoacetica ATCC 39073 YP_430930 344 Desulfitobacterium hafniense Y51 YP_520289 894 Desulfotomaculum reducens MI-1 YP_001112992 488 Chlorobium tepidum TLS NP_662697 Chlorobium phaeobacteroides DSM 266 YP_911179 1000 Pelodictyon luteolum DSM 273 YP_374406 630 Prosthecochloris vibrioformis DSM 265 YP_001130055 979 Listeria welshimeri serovar 6b str. SLCC5334 YP_850867 Listeria monocytogenes EGD-e NP_466240 Listeria innocua Clip11262 NP_472194 1000 972 Listeria monocytogenes str. 4b F2365 YP_015286 812 506 597 Bacillus licheniformis ATCC 14580 YP_081211 922 Bacillus licheniformis ATCC 14580 YP_093640 1000 Bacillus pumilus SAFR-032 YP_001488727 968 Bacillus subtilis subsp. subtilis str. 168 NP_391755 522 421 Bacillus amyloliquefaciens FZB42 YP_001423161 1000 Bacillus weihenstephanensis KBAB4 YP_001644670 Bacillus cereus ATCC 14579 NP_831708 Bacillus cereus ATCC 10987 NP_978337 1000 Bacillus thuringiensis str. Al Hakam YP_894553 629 530 Bacillus thuringiensis serovar konkukian str. 97-27 YP_036109 737 Bacillus cereus E33L YP_083355 591 660 Bacillus anthracis str. Sterne YP_028067 618 0 0 Bacillus anthracis str. Ames NP_844352 2 6 0 0 1 293 4 Bacillus anthracis str. Ames Ancestor YP_018587 696 Lactobacillus casei ATCC 334 YP_805320 Lactococcus lactis subsp. cremoris SK11 YP_808720 Lactococcus lactis subsp. lactis Il1403 NP_266860 Lactococcus lactis subsp. cremoris MG1363 YP_001033135 1000 333 726 Enterococcus faecalis V583 NP_815724 Lactobacillus salivarius UCC118 YP_535923 Lactobacillus reuteri F275 YP_001271110 760 519 867 Streptococcus agalactiae 2603V R NP_688732 559 Streptococcus agalactiae NEM316 NP_736221 450 1000 Streptococcus agalactiae A909 YP_330350 506 Lactobacillus plantarum WCFS1 NP_784802 800 Lactobacillus brevis ATCC 367 YP_795748 426 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 YP_818047 259 Leuconostoc citreum KM20 YP_001727748 1000 Oenococcus oeni PSU-1 YP_811337 684 Lactobacillus casei ATCC 334 YP_807394 493 Lactobacillus johnsonii NCC 533 NP_965789 661 Lactobacillus gasseri ATCC 33323 YP_819534 1000 Herpetosiphon aurantiacus ATCC 23779 YP_001546523 Deinococcus geothermalis DSM 11300 YP_594212 Acidothermus cellulolyticus 11B YP_872359 284 Leifsonia xyli subsp. xyli str. CTCB07 YP_062182 875 Clavibacter michiganensis subsp. michiganensis NCPPB 382 YP_001222283 526 1000 Clavibacter michiganensis subsp. sepedonicus YP_001710473 999 849 Thermobifida fusca YX YP_288699 Streptomyces coelicolor A32 NP_628129 362 Streptomyces avermitilis MA-4680 NP_825437 629 1000 Nocardioides sp. JS614 YP_922152 Propionibacterium acnes KPA171202 YP_054891 Kineococcus radiotolerans SRS30216 YP_001361392 246 Salinispora tropica CNB-440 YP_001159165 72 181 314 Salinispora arenicola CNS-205 YP_001537316 1000 Saccharopolyspora erythraea NRRL 2338 YP_001102421 Renibacterium salmoninarum ATCC 33209 YP_001625560 993 Arthrobacter sp. FB24 YP_831116 160 1000 Arthrobacter aurescens TC1 YP_947528 1000 Nocardia farcinica IFM 10152 YP_116794 Rhodococcus sp. RHA1 YP_704790 Mycobacterium abscessus YP_001703364 308 909 Corynebacterium diphtheriae NCTC 13129 NP_940235 732 245 Corynebacterium urealyticum DSM 7109 YP_001799459 Corynebacterium efficiens YS-314 NP_737863 813 Corynebacterium glutamicum R YP_001138114 1000 Corynebacterium glutamicum ATCC 13032 NP_600377 880 1000 Corynebacterium glutamicum ATCC 13032 YP_225441 1000 940 Mycobacterium vanbaalenii PYR-1 YP_953643 Mycobacterium gilvum PYR-GCK YP_001134847 959 Mycobacterium sp. JLS YP_001071322 1000 Mycobacterium sp. MCS YP_640199 1000 Mycobacterium sp. KMS YP_939079 819 Mycobacterium smegmatis str. MC2 155 YP_887546 973 Mycobacterium avium subsp. paratuberculosis K-10 NP_960250 Mycobacterium avium 104 YP_882347 1000 919 Mycobacterium bovis BCG str. Pasteur 1173P2 YP_977753 Mycobacterium tuberculosis H37Ra YP_001282941 661 755 Mycobacterium tuberculosis F11 YP_001287584 Mycobacterium bovis AF2122 97 NP_855302 1000 Mycobacterium tuberculosis H37Rv YP_177824 537 Mycobacterium tuberculosis CDC1551 NP_336115 778 Desulfotalea psychrophila LSv54 YP_064662 Porphyromonas gingivalis W83 NP_905143 Parabacteroides distasonis ATCC 8503 YP_001303989 536 Bacteroides vulgatus ATCC 8482 YP_001300067 1000 Bacteroides thetaiotaomicron VPI-5482 NP_810123 604 810 Bacteroides fragilis YCH46 YP_099157 1000 997 Bacteroides fragilis NCTC 9343 YP_211570 1000 Nitratiruptor sp. SB155-2 YP_001355620 Arcobacter butzleri RM4018 YP_001490018 Campylobacter curvus 525.92 YP_001409213 537 Campylobacter concisus 13826 YP_001467777 386 1000 Campylobacter hominis ATCC BAA-381 YP_001406208 752 Wolinella succinogenes DSM 1740 NP_907966 Helicobacter hepaticus ATCC 51449 NP_860634 468 Campylobacter jejuni RM1221 YP_178101 550 Campylobacter jejuni subsp. jejuni 81-176 YP_999807 956 Campylobacter jejuni subsp. jejuni NCTC 11168 NP_281294 1000 Campylobacter jejuni subsp. jejuni 81116 YP_001481651 150 318 Campylobacter jejuni subsp. doylei 269.97 YP_001397340 879 672 Acidiphilium cryptum JF-5 YP_001234760 Coxiella burnetii RSA 331 YP_001596164 Coxiella burnetii Dugway 5J108-111 YP_001425202 1000 Coxiella burnetii RSA 493 NP_819263 672 Francisella philomiragia subsp. philomiragia ATCC 25017 YP_001677353 924 Francisella tularensis subsp. holarctica YP_512984 Francisella tularensis subsp. holarctica OSU18 YP_762850 1000 Francisella tularensis subsp. holarctica FTA YP_001427637 445 Francisella tularensis subsp. tularensis SCHU S4 YP_169329 975 Francisella tularensis subsp. tularensis FSC198 YP_666461 731 Francisella tularensis subsp. tularensis WY96-3418 YP_001122598 932 Francisella tularensis subsp. novicida U112 YP_897857 730 Coxiella burnetii RSA 493 NP_819973 941 Coxiella burnetii RSA 331 YP_001596747 1000 Coxiella burnetii Dugway 5J108-111 YP_001424453 563 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 YP_095233 974 Legionella pneumophila str. Lens YP_126561 961 Legionella pneumophila str. Paris YP_123528 1000 Legionella pneumophila str. Corby YP_001249996 546 Xanthomonas campestris pv. campestris str. ATCC 33913 NP_637588 Xanthomonas campestris pv. campestris str. 8004 YP_242968 1000 Xanthomonas axonopodis pv. citri str. 306 NP_642653 1000 940 Xanthomonas campestris pv. vesicatoria str. 85-10 YP_364266 1000 Bordetella petrii DSM 12804 YP_001629059 792 Bordetella pertussis Tohama I NP_879142 542 Bordetella bronchiseptica RB50 NP_891032 1000 1000 Bordetella parapertussis 12822 NP_886170 654 Methylobacterium extorquens PA1 YP_001638832 737 Hyphomonas neptunium ATCC 15444 YP_760367 Sphingomonas wittichii RW1 YP_001264219 498 Caulobacter crescentus CB15 NP_419579 994 718 Caulobacter sp. K31 YP_001682265 999 Delftia acidovorans SPH-1 YP_001563420 434 Herminiimonas arsenicoxydans YP_001099673 586 Janthinobacterium sp. Marseille YP_001353704 849 Azorhizobium caulinodans ORS 571 YP_001523500 988 Rhizobium leguminosarum bv. viciae 3841 YP_765564 Agrobacterium tumefaciens str. C58 NP_356555 648 645 Ochrobactrum anthropi ATCC 49188 YP_001372076 412 Brucella suis ATCC 23445 YP_001622325 Brucella canis ATCC 23365 YP_001594460 996 Brucella abortus biovar 1 str. 9-941 YP_223479 1000 Brucella suis 1330 NP_699697 242 Brucella melitensis biovar Abortus 2308 YP_418900 211 845 Brucella melitensis 16M NP_541738 263 222 Brucella ovis ATCC 25840 YP_001257479 308 Dichelobacter nodosus VCS1703A YP_001209030 Psychrobacter sp. PRwf-1 YP_001279232 957 Rhodoferax ferrireducens T118 YP_523610 712 Azoarcus sp. BH72 YP_932736 589 Aeromonas hydrophila subsp. hydrophila ATCC 7966 YP_856176 148 Aeromonas salmonicida subsp. salmonicida A449 YP_001142488 1000 Burkholderia xenovorans LB400 YP_556904 Burkholderia xenovorans LB400 YP_559109 1000 502 Burkholderia multivorans ATCC 17616 YP_001578676 Burkholderia cenocepacia AU 1054 YP_622077 999 Burkholderia cenocepacia HI2424 YP_836460 738 Burkholderia cenocepacia MC0-3 YP_001766109 880 Burkholderia vietnamiensis G4 YP_001120748 766 Burkholderia sp. 383 YP_370385 223 Burkholderia ambifaria AMMD YP_774767 438 500 Burkholderia ambifaria MC40-6 YP_001809428 273 711 Burkholderia thailandensis E264 YP_441012 Burkholderia mallei NCTC 10229 YP_001027424 Burkholderia pseudomallei 668 YP_001057598 752 808 Burkholderia mallei SAVP1 YP_991499 487 Burkholderia mallei NCTC 10247 YP_001082389 975 492 Burkholderia pseudomallei 1106a YP_001064844 Burkholderia pseudomallei 1710b YP_332143 527 508 Burkholderia pseudomallei K96243 YP_107128 597 Burkholderia mallei ATCC 23344 YP_104657 789 Methylococcus capsulatus str. Bath YP_113575 Marinomonas sp. MWYL1 YP_001340368 Pseudomonas stutzeri A1501 YP_001171817 Acinetobacter sp. ADP1 YP_046898 804 Acinetobacter baumannii SDF YP_001707382 992 Acinetobacter baumannii ATCC 17978 YP_001084953 999 999 Acinetobacter baumannii AYE YP_001713530 869 Rhodopseudomonas palustris HaA2 YP_484550 Colwellia psychrerythraea 34H YP_268606 258 Pseudoalteromonas haloplanktis TAC125 YP_340517 558 893 Pseudoalteromonas atlantica T6c YP_661029 1000 Psychromonas ingrahamii 37 YP_942171 Shewanella frigidimarina NCIMB 400 YP_749833 Shewanella denitrificans OS217 YP_562283 893 336 Shewanella amazonensis SB2B YP_928224 Shewanella loihica PV-4 YP_001093431 999 468 Shewanella sediminis HAW-EB3 YP_001474850 Shewanella woodyi ATCC 51908 YP_001759946 548 630 354 Shewanella pealeana ATCC 700345 YP_001501180 711 Shewanella halifaxensis HAW-EB4 YP_001673607 966 Shewanella baltica OS155 YP_001051330 175 Shewanella baltica OS195 YP_001555559 1000 Shewanella baltica OS185 YP_001367187 496 Shewanella sp. W3-18-1 YP_962763 434 Shewanella putrefaciens CN-32 YP_001184161 1000 Shewanella oneidensis MR-1 NP_718840 375 Shewanella sp. ANA-3 YP_868882 95 Shewanella sp. MR-4 YP_733376 849 997 Shewanella sp. MR-7 YP_737366 554 93 Haemophilus ducreyi 35000HP_NP_874145 Actinobacillus pleuropneumoniae L20 YP_001053006 1000 Actinobacillus pleuropneumoniae serovar 3 str. JL03 YP_001651345 1000 Pasteurella multocida subsp. multocida str. Pm70 NP_245911 999 Haemophilus somnus 129PT YP_718464 Haemophilus somnus 2336 YP_001783482 873 1000 Mannheimia succiniciproducens MBEL55E YP_087907 Actinobacillus succinogenes 130Z YP_001345083 695 700 Haemophilus influenzae 86-028NP_YP_248744 496 Haemophilus influenzae Rd KW20 NP_439232 1000 Haemophilus influenzae PittGG YP_001292989 691 824 Haemophilus influenzae PittEE YP_001291064 542 Escherichia coli UTI89 YP_540061 Escherichia coli APEC O1 YP_852100 651 Salmonella enterica subsp. arizonae serovar 62 YP_001570193 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 YP_150363 Salmonella typhimurium LT2 NP_460748 997 1000 Salmonella enterica subsp. enterica serovar Typhi str. CT18 NP_456301 995 347 Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7 YP_001587668 345 Shigella sonnei Ss046 YP_309953 399 166 Escherichia coli CFT073 NP_753044 92 Shigella dysenteriae Sd197 YP_402616 Escherichia coli str. K-12 substr. MG1655 NP_415497 485 Escherichia coli str. K12 substr. W3110 AP_001607 642 Escherichia coli DH10B YP_001729955 321 Escherichia coli HS YP_001457815 34 Escherichia coli E24377A YP_001462209 Escherichia coli 536 YP_668897 118 Shigella flexneri 5 str. 8401 YP_688512 76 Shigella flexneri 2a str. 2457T NP_836687 22 Escherichia coli O157 H7 str. Sakai NP_309161 25 Escherichia coli O157 H7 EDL933 NP_286915 30 Shigella flexneri 2a str. 301 NP_706901 52 Escherichia coli SECEC SMS-3-5 YP_001744190 46 42 Shigella boydii Sb227 YP_408646 79 Aeromonas hydrophila subsp. hydrophila ATCC 7966 YP_858102 Aeromonas salmonicida subsp. salmonicida A449 YP_001140647 1000 Photobacterium profundum SS9 YP_130739 Vibrio fischeri ES114 YP_204336 Vibrio cholerae O1 biovar eltor str. N16961 NP_231478 925 Vibrio cholerae O395 YP_001217378 1000 635 Vibrio vulnificus CMCP6 NP_761020 Vibrio vulnificus YJ016 NP_935076 196 1000 Vibrio cholerae O1 biovar eltor str. N16961 NP_233258 Vibrio cholerae O395 YP_001215206 414 1000 Vibrio parahaemolyticus RIMD 2210633 NP_797432 286 Vibrio harveyi ATCC BAA-1116 YP_001444799 853 Yersinia enterocolitica subsp. enterocolitica 8081 YP_001007127 475 Yersinia pestis CO92 NP_404730 Yersinia pestis KIM NP_670362 924 870 Yersinia pseudotuberculosis IP_32953 YP_069686 Yersinia pestis biovar Microtus str. 91001 NP_992412 999 812 Yersinia pestis Antiqua YP_650508 Yersinia pestis Nepal516 YP_648808 812 823 Yersinia pestis Pestoides F YP_001163920 Yersinia pseudotuberculosis IP_31758 YP_001401839 832 851 993 Yersinia pestis Angola YP_001605914 907 Yersinia pseudotuberculosis YPIII YP_001721691 963 Photorhabdus luminescens subsp. laumondii TTO1 NP_928745 Serratia proteamaculans 568 YP_001477503 Pectobacterium atrosepticum SCRI1043 YP_051089 661 Pectobacterium atrosepticum SCRI1043 YP_049471 221 381 Sodalis glossinidius str. morsitans YP_454560 496 Enterobacter sakazakii ATCC BAA-894 YP_001438690 Enterobacter sp. 638 YP_001175962 439 534 Klebsiella pneumoniae subsp. pneumoniae MGH 78578 YP_001334409 716 Citrobacter koseri ATCC BAA-895 YP_001453963 Salmonella enterica subsp. arizonae serovar 62 YP_001571210 Salmonella typhimurium LT2 NP_459725 640 982 Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7 YP_001588992 867 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 YP_151218 931 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 YP_215731 230 329 Salmonella enterica subsp. enterica serovar Typhi str. CT18 NP_455296 789 362 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 NP_805890 949 Escherichia coli str. K12 substr. W3110 AP_001370 Shigella flexneri 2a str. 2457T NP_836275 Escherichia coli str. K-12 substr. MG1655 NP_415261 980 Escherichia coli UTI89 YP_539751 313 Shigella boydii Sb227 YP_407107 221 Escherichia coli O157 H7 str. Sakai NP_308795 135 Escherichia coli CFT073 NP_752741 65 Escherichia coli DH10B YP_001729719 16 Escherichia coli E24377A YP_001461893 Shigella sonnei Ss046 YP_309676 Escherichia coli 536 YP_668668 Shigella dysenteriae Sd197 YP_402357 85 Shigella flexneri 2a str. 301 NP_706501 Escherichia coli HS YP_001457533 Escherichia coli O157 H7 EDL933 NP_286461 Escherichia coli APEC O1 YP_851837 Escherichia coli SECEC SMS-3-5 YP_001742843 25 Shigella flexneri 5 str. 8401 YP_688161 92 1000 Euryarchaeota (Halobacteriales) 70 68 133 734 978 Actinobacteria Chloroflexi Firmicute Bacteroidetes/Chlorobi Delta-Proteobacteria 1000 937 1000 1000 992 982 510 506 1000 987 991 756 1000 874 1000 1000 1000 983 415 1000 936 55 577 647 997 137 996 32 733 1000 1000 999 862 Firmicutes Euryarchaota (Thermoplasmatales) 1000 548 724 637 991 994 1000 992 987 1000 1000 781 491 1000 674 66 41 156 62 791 77 58 169 345 255 540 Delta-Proteobacteria Beta-Proteobacteria 858 1000 1000 1000 1000 1000 827 Cyanobacteria 687 459 1000 844 779 720 716 449 1000 887 1000 363 837 913 304 1000 807 752 910 1000 802 270 122 233 572 1000 1000 426 974 294 123 1000 84 1000 996 107 445 675 953 691 893 529 760 1000 71 910 1000 595 250 995 346 1000 664 1000 1000 649 1000 1000 346 999 780 549 182 1000 1000 1000 998 450 988 1000 1000 973 381 1000 1000 136 852 896 683 947 444 838 659 831 482 749 958 993 155 540 998 1000 422 47 1000 760 523 81 960 1000 143 981 810 850 797 Alpha-Proteobacteria Beta-Proteobacteria Gamma-Proteobacteria 288 1000 42 497 680 113 518 1000 689 790 580 895 1000 1000 978 1000 1000 996 658 982 831 751 697 537 923 821 793 838 456 921 788 746 545 670 998 899 321 775 976 535 991 575 535 593 758 17 414 734 486 Bacteroidetes/Chlorobi Acidobacteria 623 PVC Delta-Proteobacteria Firmicutes Aquificales 374 Delta-Proteobacteria 770 Firmicutes Bacteroidetes/Chlorobi Euryarchaeota (Methanosarcinales) 412 Chloroflexi Deinococcus/Thermus Actinobacteria 488 Bacteroidetes Epsilon-Proteobacteria 924 Alpha-proteobacteria Beta-Proteobacteria Gamma-Proteobacteria 180 838 0.1 Suppl. Mat. 2

2. 876 1000 890 1000 596 929 878 585 658 970 983 1000 354 649 1000 999 1000 704 992 800 1000 886 703 1000 476 265 1000 641 667 914 735 595 1000 915 203 908 919 1000 773 965 615 989 529 928 999 1000 635 596 1000 997 1000 1000 1000 470 935 1000 999 523 409 386 1000 733 473 573 934 999 848 486 990 960 627 988 759 535 742 998 998 372 1000 1000 244 347 903 183 200 1000 959 1000 809 971 825 945 607 992 451 1000 409 712 274 1000 1000 119 195 275 201 364 1000 781 1000 829 444 930 574 1000 581 568 427 1000 173 1000 438 998 977 924 690 602 588 1000 915 430 547 445 1000 613 939 929 312 131 476 101 136 452 342 696 340 340 409 997 363 936 733 910 524 997 691 676 489 1000 927 224 277 743 687 994 993 541 652 845 447 1000 271 509 366 983 705 965 785 846 1000 474 822 831 815 447 976 822 984 999 618 993 825 912 999 828 747 1000 694 919 1000 988 430 1000 830 658 596 637 1000 928 268 925 789 291 393 Firmicutes Acidobacteria PVC Symbiobacterium thermophilum IAM 14863 YP_076979 Solibacter usitatus Ellin6076 YP_824765 Candidatus Protochlamydia amoebophila UWE25 YP_008977 Gramella forsetii KT0803 YP_861439 Flavobacterium psychrophilum JIP02 86 YP_001295831 Methylobacillus flagellatus KT YP_545543 Salinibacter ruber DSM 13855 YP_444468 Ralstonia metallidurans CH34 YP_584521 Beta-Proteobacteria Bacteroidetes/Chlorobi Burkholderia thailandensis E264 YP_439812 Burkholderia ambifaria MC40-6 YP_001811293 Azoarcus sp. EbN1 YP_158648 Ralstonia solanacearum GMI1000 NP_522554 Ralstonia metallidurans CH34 YP_586456 Polaromonas sp. JS666 YP_548116 Nitrosomonas eutropha C91 YP_747791 Rhodoferax ferrireducens T118 YP_525356 Synechococcus elongatus PCC 7942 YP_399221 Cyanobacteria Synechococcus elongatus PCC 6301 YP_172019 Delta-Proteobacteria Bacteroidetes/Chlorobi Chlorobium chlorochromatii CaD3 YP_379659 Anaeromyxobacter dehalogenans 2CP-C YP_464382 Anaeromyxobacter sp. Fw109-5 YP_001378410 Helicobacter hepaticus ATCC 51449 NP_860787 Wolinella succinogenes DSM 1740 NP_906440 Helicobacter acinonychis str. Sheeba YP_664165 Helicobacter pylori J99 NP_222853 Helicobacter pylori 26695 NP_206943 Helicobacter pylori HPAG1 YP_626883 Sulfurimonas denitrificans DSM 1251 YP_392597 Arcobacter butzleri RM4018 YP_001490968 Nitratiruptor sp. SB155-2 YP_001357081 Epsilon-Proteobacteria Sulfurovum sp. NBC37-1 YP_001357495 Campylobacter hominis ATCC BAA-381 YP_001406948 Campylobacter fetus subsp. fetus 82-40 YP_891580 Campylobacter curvus 525.92 YP_001407573 Campylobacter jejuni subsp. doylei 269.97 YP_001398790 Campylobacter jejuni subsp. jejuni 81-176 YP_001001138 Campylobacter jejuni subsp. jejuni 81116 YP_001482970 Campylobacter jejuni RM1221 YP_179644 Campylobacter jejuni subsp. jejuni NCTC 11168 NP_282628 Leptospira borgpetersenii serovar Hardjo-bovis L550 YP_798081 Spirochetes Leptospira borgpetersenii serovar Hardjo-bovis JB197 YP_800805 Bdellovibrio bacteriovorus HD100 NP_969411 Myxococcus xanthus DK 1622 YP_633680 Delta-Proteobacteria Bacteroidetes/Chlorobi PVC Rhodopirellula baltica SH 1 NP_867199 Cytophaga hutchinsonii ATCC 33406 YP_677753 Candidatus Sulcia muelleri GWSS YP_001597952 Gramella forsetii KT0803 YP_861474 Flavobacterium johnsoniae UW101 YP_001194883 Flavobacterium psychrophilum JIP02 86 YP_001296054 Thiobacillus denitrificans ATCC 25259 YP_314096 Methylobacillus flagellatus KT YP_544740 Magnetococcus sp. MC-1 YP_866259 Thiomicrospira crunogena XCL-2 YP_392229 Candidatus Ruthia magnifica str. Cm Calyptogena magnifica YP_903313 Candidatus Vesicomyosocius okutanii HA YP_001218903 Rhodospirillum rubrum ATCC 11170 YP_428413 Silicibacter pomeroyi DSS-3 YP_165019 Sphingomonas wittichii RW1 YP_001262300 Mesorhizobium sp. BNC1 YP_674805 Rhizobium leguminosarum bv. viciae 3841 YP_766146 Sinorhizobium meliloti 1021 NP_435566 Sinorhizobium medicae WSM419 YP_001314551 Parvibaculum lavamentivorans DS-1 YP_001412808 Caulobacter crescentus CB15 NP_420214 Caulobacter sp. K31 YP_001684062 Maricaulis maris MCS10 YP_756380 Hyphomonas neptunium ATCC 15444 YP_759950 Methylobacterium sp. 4-46 YP_001770109 Xanthobacter autotrophicus Py2 YP_001415374 Azorhizobium caulinodans ORS 571 YP_001527439 Rhodopseudomonas palustris CGA009 NP_945375 Rhodopseudomonas palustris HaA2 YP_483640 Rhodopseudomonas palustris BisB5 YP_567869 Rhodopseudomonas palustris BisB18 YP_529913 Rhodopseudomonas palustris BisA53 YP_778959 Bradyrhizobium japonicum USDA 110 NP_769403 Bradyrhizobium sp. ORS278 YP_001204500 Bradyrhizobium sp. BTAi1 YP_001238831 Jannaschia sp. CCS1 YP_511799 Paracoccus denitrificans PD1222 YP_915641 Rhodobacter sphaeroides ATCC 17025 YP_001166745 Rhodobacter sphaeroides 2.4.1 YP_353773 Rhodobacter sphaeroides ATCC 17029 YP_001044225 Dinoroseobacter shibae DFL 12 YP_001532008 Silicibacter pomeroyi DSS-3 YP_168721 Roseobacter denitrificans OCh 114 YP_681602 Silicibacter sp. TM1040 YP_614539 Novosphingobium aromaticivorans DSM 12444 YP_497848 Sphingopyxis alaskensis RB2256 YP_616722 Mesorhizobium loti MAFF303099 NP_106928 Mesorhizobium loti MAFF303099 NP_107099 Agrobacterium tumefaciens str. C58 NP_354541 Sinorhizobium meliloti 1021 NP_435911 Sinorhizobium meliloti 1021 NP_435656 Sinorhizobium medicae WSM419 YP_001314560 Sinorhizobium medicae WSM419 YP_001314800 Rhizobium leguminosarum bv. viciae 3841 YP_765315 Rhizobium leguminosarum bv. viciae 3841 YP_770482 Rhizobium etli CFN 42 NP_659746 Rhizobium etli CFN 42 YP_473123 Ochrobactrum anthropi ATCC 49188 YP_001369029 Brucella abortus biovar 1 str. 9-941 YP_221148 Brucella suis 1330 NP_697395 Brucella canis ATCC 23365 YP_001592230 Brucella melitensis 16M NP_540481 Brucella melitensis biovar Abortus 2308 YP_413854 Brucella ovis ATCC 25840 YP_001258397 Brucella suis ATCC 23445 YP_001627054 Vibrio harveyi ATCC BAA-1116 YP_001447597 Shewanella pealeana ATCC 700345 YP_001500817 Alcanivorax borkumensis SK2 YP_693071 Psychrobacter sp. PRwf-1 YP_001280634 Psychrobacter arcticus 273-4 YP_264065 Psychrobacter cryohalolentis K5 YP_580051 Alkalilimnicola ehrlichei MLHE-1 YP_742716 Thiobacillus denitrificans ATCC 25259 YP_314401 Ralstonia solanacearum GMI1000 NP_519397 Ralstonia eutropha H16 YP_726783 Ralstonia eutropha JMP134 YP_296249 Ralstonia metallidurans CH34 YP_584192 Polynucleobacter sp. QLW-P1DMWA-1 YP_001155237 Polynucleobacter necessarius STIR1 YP_001798088 Bordetella petrii DSM 12804 YP_001631855 Bordetella parapertussis 12822 NP_884049 Bordetella bronchiseptica RB50 NP_889864 Dechloromonas aromatica RCB YP_283939 Azoarcus sp. EbN1 YP_159939 Azoarcus sp. BH72 YP_932845 Chromobacterium violaceum ATCC 12472 NP_900844 Neisseria gonorrhoeae FA 1090 YP_208434 Neisseria meningitidis Z2491 NP_284684 Neisseria meningitidis MC58 NP_274728 Alpha-Proteobacteria Beta-Proteobacteria Gamma-Proteobacteria Neisseria meningitidis 053442 YP_001599744 Neisseria meningitidis FAM18 YP_975604 Herminiimonas arsenicoxydans YP_001099927 Janthinobacterium sp. Marseille YP_001353321 Methylibium petroleiphilum PM1 YP_001021668 Rhodoferax ferrireducens T118 YP_523187 Polaromonas naphthalenivorans CJ2 YP_983999 Polaromonas sp. JS666 YP_551095 Acidovorax avenae subsp. citrulli AAC00-1 YP_969886 Verminephrobacter eiseniae EF01-2 YP_995960 Acidovorax sp. JS42 YP_985395 Delftia acidovorans SPH-1 YP_001563798 Leptothrix cholodnii SP-6 YP_001791809 Pseudoalteromonas atlantica T6c YP_661645 Colwellia psychrerythraea 34H YP_268725 Pseudoalteromonas haloplanktis TAC125 YP_340357 Idiomarina loihiensis L2TR YP_155686 Psychromonas ingrahamii 37 YP_942380 Aeromonas hydrophila subsp. hydrophila ATCC 7966 YP_856818 Aeromonas salmonicida subsp. salmonicida A449 YP_001141804 Photobacterium profundum SS9 YP_130037 Vibrio fischeri ES114 YP_204682 Vibrio harveyi ATCC BAA-1116 YP_001445492 Vibrio cholerae O1 biovar eltor str. N16961 NP_231085 Vibrio cholerae O395 YP_001216999 Vibrio parahaemolyticus RIMD 2210633 NP_797923 Vibrio vulnificus CMCP6 NP_761442 Vibrio vulnificus YJ016 NP_934464 Shewanella pealeana ATCC 700345 YP_001502069 Shewanella halifaxensis HAW-EB4 YP_001674415 Shewanella amazonensis SB2B YP_927666 Shewanella loihica PV-4 YP_001094110 Shewanella sediminis HAW-EB3 YP_001473948 Shewanella woodyi ATCC 51908 YP_001760798 Shewanella oneidensis MR-1 NP_717954 Shewanella sp. ANA-3 YP_869743 Shewanella sp. MR-4 YP_734136 Shewanella sp. MR-7 YP_738015 Shewanella sp. W3-18-1 YP_963429 Shewanella putrefaciens CN-32 YP_001183481 Shewanella denitrificans OS217 YP_562858 Shewanella frigidimarina NCIMB 400 YP_750694 Shewanella baltica OS195 YP_001554649 Shewanella baltica OS185 YP_001366375 Shewanella baltica OS155 YP_001041605 Shewanella baltica OS155 YP_001050566 Saccharophagus degradans 2-40 YP_527894 Hahella chejuensis KCTC 2396 YP_433526 Marinobacter aquaeolei VT8 YP_959053 Pseudomonas aeruginosa UCBPP-PA14 YP_791695 Pseudomonas aeruginosa PA7 YP_001349127 Pseudomonas aeruginosa PAO1 NP_250248 Pseudomonas mendocina ymP_YP_001188087 Pseudomonas stutzeri A1501 YP_001172359 Pseudomonas fluorescens Pf-5 YP_259044 Pseudomonas fluorescens PfO-1 YP_347559 Pseudomonas entomophila L48 YP_607455 Pseudomonas putida W619 YP_001750420 Pseudomonas putida GB-1 YP_001670042 Pseudomonas putida KT2440 NP_746366 Pseudomonas putida F1 YP_001266958 Pseudomonas stutzeri A1501 YP_001172356 Pseudomonas mendocina ymP_YP_001188092 Pseudomonas aeruginosa PA7 YP_001349131 Pseudomonas aeruginosa PAO1 NP_250245 Pseudomonas aeruginosa UCBPP-PA14 YP_791698 Pseudomonas fluorescens Pf-5 YP_259940 Pseudomonas fluorescens PfO-1 YP_348243 Pseudomonas aeruginosa PA7 YP_001346344 Pseudomonas aeruginosa PAO1 NP_252822 Pseudomonas aeruginosa UCBPP-PA14 YP_788989 Pseudomonas aeruginosa PA7 YP_001348796 Pseudomonas aeruginosa PAO1 NP_250547 Pseudomonas aeruginosa UCBPP-PA14 YP_791385 Pseudomonas fluorescens PfO-1 YP_347555 Pseudomonas fluorescens Pf-5 YP_259040 Pseudomonas syringae pv. tomato str. DC3000 NP_791827 0.1 Pseudomonas syringae pv. syringae B728a YP_236483 Pseudomonas syringae pv. phaseolicola 1448A YP_275495 Pseudomonas entomophila L48 YP_607451 Suppl. Mat. 3 Pseudomonas putida KT2440 NP_746371 Pseudomonas putida F1 YP_001266953 Pseudomonas putida GB-1 YP_001670046 Pseudomonas putida W619 YP_001750424

3. 0.1 Sulfolobus acidocaldarius DSM 639 YP_254815 87 1. Sulfolobus solfataricus P2 NP_341619 Metallosphaera sedula DSM 5348 YP_001192096 100/1. Dox Sulfolobus tokodaii str. 7 NP_378042 35/. Metallosphaera sedula DSM 5348 YP_001190669 27/.96 Sulfolobus tokodaii str. 7 NP_376567 80/.77 Sulfolobus tokodaii str. 7 NP_376500 63/.78 Crenarchaeota (Sulfolobales) Sulfolobus tokodaii str. 7 NP_378599 Metallosphaera sedula DSM 5348 YP_001190585 100/1. Metallosphaera sedula DSM 5348 YP_001190586 948 Sulfolobus tokodaii str. 7 NP_378396 1000 Metallosphaera sedula DSM 5348 YP_001190391 721 1000 Sulfolobus tokodaii str. 7 NP_375983 Sulfolobus solfataricus P2 NP_343985 1000 Sulfolobus acidocaldarius DSM 639 YP_256675 1000 Crenarchaeota (Thermoproteales) Caldivirga maquilingensis IC-167 YP_001541744 Geobacillus thermodenitrificans NG80-2 YP_001125633 Firmicutes Geobacillus kaustophilus HTA426 YP_147524 1000 908 Nitrosospira multiformis ATCC 25196 YP_413345 Azoarcus sp. EbN1 YP_159094 1000 1000 Nitrobacter hamburgensis X14 YP_577950 Alpha-Proteobacteria Beta-Proteobacteria Gamma-Proteobacteria 480 Silicibacter pomeroyi DSS-3 YP_165013 500 Nitrosococcus oceani ATCC 19707 YP_344942 413 Nitrosomonas eutropha C91 YP_748072 795 985 Nitrosomonas europaea ATCC 19718 NP_840762 1000 Actinobacteria Nocardioides sp. JS614 YP_922823 Epsilon-proteobacteria Sulfurovum sp. NBC37-1 YP_001357604 1000 Euryarchaeota (Halobacteriales) Sulfurimonas denitrificans DSM 1251 YP_392620 839 Natronomonas pharaonis DSM 2160 YP_330877 Alpha-Proteobacteria Magnetospirillum magneticum AMB-1 YP_421585 1000 536 Aeropyrum pernix K1 NP_148062 Crenarchaeota (Thermoproteales, Desulfurococcales) Pyrobaculum calidifontis JCM 11548 YP_001056831 993 Pyrobaculum aerophilum str. IM2 NP_559246 1000 987 Aquifex aeolicus VF5 NP_214506 Aquificales Exiguobacterium sibiricum 255-15 YP_001813096 524 Bacillus halodurans C-125 NP_241605 806 Oceanobacillus iheyensis HTE831 NP_692667 Firmicutes 1000 Geobacillus thermodenitrificans NG80-2 YP_001125509 883 457 Geobacillus kaustophilus HTA426 YP_147399 1000 Bacteroidetes Chlorobi Salinibacter ruber DSM 13855 YP_444460 381 Halobacterium salinarum R1 YP_001689972 1000 Halobacterium sp. NRC-1 NP_444237 1000 Euryarchaeota (Halobacteriales) Haloarcula marismortui ATCC 43049 YP_135811 938 Natronomonas pharaonis DSM 2160 YP_327130 521 Halorubrum lacusprofundi ATCC 49239 ZP_02014739 996 453 Chloroflexus aurantiacus J-10-fl YP_001636024 Roseiflexus castenholzii DSM 13941 YP_001431686 Chloroflexi 1000 589 Roseiflexus sp. RS-1 YP_001275293 999 Deinococcus geothermalis DSM 11300 YP_603490 Deinococcus /Thermus Thermus thermophilus HB8 YP_144401 960 Thermus thermophilus HB27 YP_004743 1000 335 Methylococcus capsulatus str. Bath YP_114811 Burkholderia xenovorans LB400 YP_556973 Burkholderia sp. 383 YP_372161 1000 456 Rhizobium etli CFN 42 YP_468520 1000 Bradyrhizobium japonicum USDA 110 NP_771120 988 Bradyrhizobium sp. ORS278 YP_001204332 Alpha-Proteobacteria Beta-Proteobacteria Gamma-Proteobacteria 873 Burkholderia vietnamiensis G4 YP_001115325 990 Burkholderia multivorans ATCC 17616 YP_001585717 1000. Burkholderia thailandensis E264 YP_443386 875 Burkholderia pseudomallei 668 YP_001058396 1000 Burkholderia pseudomallei 1710b YP_332896 558 Burkholderia pseudomallei K96243 YP_107881 478 Burkholderia pseudomallei 1106a YP_001065632 614 Suppl. Mat. 4

4. Picrophilus torridus DSM 9790 YP_024082 Ferroplasma acidarmanus fer1 ZP_01709051 Aeropyrum pernix K1 NP_147500 Halorubrum lacusprofundi ATCC 49239 ZP_02015599 Crenarchaeota (Desulfurococcales) (Sulfolobales) (Thermoproteales) Euryarchaeota (Thermoplasmatales) (Halobacteriales) Thaumarchaeota Haloarcula marismortui ATCC 43049 YP_136841 Haloferax volcanii AAK14378 Nitrosopumilus maritimus SCM1 YP_001581518 Cenarchaeum symbiosum A YP_876890 Pyrobaculum aerophilum str. IM2 NP_559235 Pyrobaculum calidifontis JCM 11548 YP_001056825 Sulfolobus acidocaldarius DSM 639 YP_256842 Sulfolobus solfataricus P2 NP_344288 Sulfolobus tokodaii str. 7 NP_375951 Metallosphaera sedula DSM 5348 YP_001190425 Haloarcula marismortui ATCC 43049 YP_135564 Halobacterium sp. NRC-1 NP_279674 Halobacterium salinarum R1 YP_001688771 Natronomonas pharaonis DSM 2160 YP_326879 Haloarcula marismortui ATCC 43049 YP_135922 Haloquadratum walsbyi DSM 16790 YP_657381 Haloferax volcanii AAK14377 Deinococcus radiodurans R1 NP_296339 Deinococcus geothermalis DSM 11300 YP_603878 Deinococci/thermus Thermus thermophilus HB27 YP_005640 Thermus thermophilus HB8 YP_143578 Aquificales Aquifex aeolicus VF5 NP_214504 Geobacter uraniireducens Rf4 YP_001229197 305 Pelobacter carbinolicus DSM 2380 YP_357934 Geobacter sulfurreducens PCA NP_951280 874 616 Geobacter metallireducens GS-15 YP_383219 1000 339 1000 Desulfovibrio desulfuricans G20 YP_388315 Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough YP_011033 1000 Desulfovibrio vulgaris subsp. vulgaris DP4 YP_966790 1000 Bdellovibrio bacteriovorus HD100 NP_967290 1000 Delta-Proteobacteria Gamma-Proteobacteria Beta-Proteobacteria Alpha-Proteobacteria Bacteroidetes/Chlorobi Acidobacteria Chloroflexi PVC Leptospira interrogans serovar Lai str. 56601 NP_710424 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 YP_000200 1000 1000 Leptospira borgpetersenii serovar Hardjo-bovis L550 YP_796822 1000 Leptospira borgpetersenii serovar Hardjo-bovis JB197 YP_801959 1000 Sorangium cellulosum So ce 56 YP_001618242 515 Rhodopirellula baltica SH 1 NP_870646 624 Salinibacter ruber DSM 13855 YP_446205 Anaeromyxobacter dehalogenans 2CP-C YP_465481 341 Sorangium cellulosum So ce 56 YP_001615167 Myxococcus xanthus DK 1622 YP_632048 710 165 63 Myxococcus xanthus DK 1622 YP_634222 1000 Anaeromyxobacter dehalogenans 2CP-C YP_464016 554 Anaeromyxobacter sp. Fw109-5 YP_001378044 217 1000 Chloroflexus aurantiacus J-10-fl YP_001635743 225 Acidobacteria bacterium Ellin345 YP_592070 Solibacter usitatus Ellin6076 YP_821793 902 997 Gluconacetobacter diazotrophicus PAl 5 YP_001602839 731 513 Methylobacterium radiotolerans JCM 2831 YP_001753729 Nitrosococcus oceani ATCC 19707 YP_343276 593 Ralstonia eutropha JMP134 YP_298631 423 Nitrobacter hamburgensis X14 YP_571634 325 Methylobacterium sp. 4-46 YP_001772537 854 1000 Methylobacterium extorquens PA1 YP_001637720 Methylobacterium radiotolerans JCM 2831 YP_001766956 990 Anabaena variabilis ATCC 29413 YP_324077 Synechocystis sp. PCC 6803 NP_441291 Anabaena variabilis ATCC 29413 YP_320079 Cyanothece sp. ATCC 51142 YP_001806228 Cyanothece sp. ATCC 51142 YP_001805524 Trichodesmium erythraeum IMS101 YP_720232 Nostoc sp. PCC 7120 NP_486772 212 Anabaena variabilis ATCC 29413 YP_324793 Synechococcus sp. PCC 7002 YP_001733987 Prochlorococcus marinus str. MIT 9515 YP_001011578 Prochlorococcus marinus str. MIT 9215 YP_001484863 999 Synechococcus sp. WH 7803 YP_001224437 1000 Synechococcus sp. RCC307 YP_001228191 Synechococcus sp. CC9605 YP_381293 Synechococcus sp. WH 8102 NP_897622 Synechococcus sp. CC9311 YP_731131 Gloeobacter violaceus PCC 7421 NP_925109 Gloeobacter violaceus PCC 7421 NP_923686 Trichodesmium erythraeum IMS101 YP_721510 Thermosynechococcus elongatus BP-1 NP_682800 Nostoc sp. PCC 7120 NP_486555 Anabaena variabilis ATCC 29413 YP_320968 Synechococcus sp. JA-3-3Ab YP_474942 Synechococcus sp. JA-2-3Ba2-13 YP_478886 Acaryochloris marina MBIC11017 YP_001518912 Cyanobacteria Nostoc sp. PCC 7120 NP_484994 Anabaena variabilis ATCC 29413 YP_321048 315 1000 183 Synechococcus sp. PCC 7002 YP_001734418 824 Cyanothece sp. ATCC 51142 YP_001803392 1000 Synechocystis sp. PCC 6803 NP_440609 922 Microcystis aeruginosa NIES-843 YP_001657308 45 436 Synechococcus elongatus PCC 6301 YP_172217 Synechococcus elongatus PCC 7942 YP_401620 1000 Synechococcus sp. WH 8102 NP_897953 Synechococcus sp. CC9902 YP_377756 430 907 Synechococcus sp. CC9605 YP_380936 646 Synechococcus sp. RCC307 YP_001226927 1000 Synechococcus sp. CC9311 YP_731328 Synechococcus sp. WH 7803 YP_001225595 829 195 Prochlorococcus marinus str. MIT 9313 NP_895169 Prochlorococcus marinus str. MIT 9303 YP_001016658 257 1000 87 Prochlorococcus marinus str. MIT 9211 YP_001550327 165 Prochlorococcus marinus subsp. marinus str. CCMP1375 NP_874835 Prochlorococcus marinus str. NATL2A YP_292967 582 Prochlorococcus marinus str. NATL1A YP_001014326 241 1000 Prochlorococcus marinus subsp. pastoris str. CCMP1986 NP_892563 519 Prochlorococcus marinus str. MIT 9515 YP_001010823 976 Prochlorococcus marinus str. MIT 9312 YP_396941 999 Prochlorococcus marinus str. AS9601 YP_001008895 580 Prochlorococcus marinus str. MIT 9215 YP_001483726 341 Prochlorococcus marinus str. MIT 9301 YP_001090693 203 Anaeromyxobacter sp. Fw109-5 YP_001380045 Acidobacteria bacterium Ellin345 YP_589517 Solibacter usitatus Ellin6076 YP_826822 1000 Cytophaga hutchinsonii ATCC 33406 YP_678811 727 Flavobacterium psychrophilum JIP02 86 YP_001295310 995 1000 Flavobacterium johnsoniae UW101 YP_001193992 986 Proteobacteria II Bacteroidetes/Chlorobi Alpha-Proteobacteria Beta-proteobacteria Gamma-Proteobacteria Acidobacteria Delta-proteobacteria Gramella forsetii KT0803 YP_860231 639 Herminiimonas arsenicoxydans YP_001099422 Polaromonas sp. JS666 YP_547581 984 685 Leptothrix cholodnii SP-6 YP_001789293 952 677 Ralstonia metallidurans CH34 YP_586093 Ralstonia eutropha JMP134 YP_297835 936 Ralstonia eutropha H16 YP_841573 822 Ralstonia solanacearum GMI1000 NP_523124 1000 Burkholderia sp. 383 YP_367049 948 Burkholderia ambifaria AMMD YP_778088 989 Burkholderia ambifaria MC40-6 YP_001815927 1000 438 Photobacterium profundum SS9 YP_132060 Methylobacterium sp. 4-46 YP_001770700 647 Mesorhizobium loti MAFF303099 NP_102720 Bradyrhizobium japonicum USDA 110 NP_770424 984 Rhizobium etli CFN 42 YP_470115 662 Rhizobium leguminosarum bv. viciae 3841 YP_768626 994 Mesorhizobium sp. BNC1 YP_675024 515 Sinorhizobium meliloti 1021 NP_386623 Sinorhizobium medicae WSM419 YP_001328093 Neorickettsia sennetsu str. Miyayama YP_506501 Wolbachia endosymbiont of Drosophila melanogaster NP_966102 Wolbachia endosymbiont strain TRS of Brugia malayi YP_198138 919 1000 Anaplasma marginale str. St. Maries YP_154146 995 Anaplasma phagocytophilum HZ YP_505633 1000 Ehrlichia chaffeensis str. Arkansas YP_507790 994 Ehrlichia canis str. Jake YP_303439 997 Ehrlichia ruminantium str. Welgevonden YP_180637 913 519 Ehrlichia ruminantium str. Welgevonden YP_197694 1000 Ehrlichia ruminantium str. Gardel YP_196734 555 Orientia tsutsugamushi str. Boryong YP_001249069 Rickettsia prowazekii str. Madrid E NP_220786 1000 Rickettsia akari str. Hartford YP_001493401 997 Rickettsia canadensis str. McKiel YP_001492392 Rickettsia felis URRWXCal2 YP_246643 520 149 Rickettsia bellii RML369-C YP_538061 179 693 Rickettsia bellii OSU 85-389 YP_001495898 1000 992 Rickettsia massiliae MTU5 YP_001499310 448 Rickettsia conorii str. Malish 7 NP_360190 841 Rickettsia rickettsii str. Sheila Smith YP_001494671 626 Rickettsia rickettsii str. Iowa YP_001649930 912 Granulibacter bethesdensis CGDNIH1 YP_746079 Acidiphilium cryptum JF-5 YP_001235284 806 Magnetospirillum magneticum AMB-1 YP_421532 Jannaschia sp. CCS1 YP_509192 Dinoroseobacter shibae DFL 12 YP_001533720 338 Roseobacter denitrificans OCh 114 YP_682261 333 1000 Silicibacter sp. TM1040 YP_614285 974 Silicibacter pomeroyi DSS-3 YP_166625 780 Paracoccus denitrificans PD1222 YP_915727 143 573 Paracoccus denitrificans PD1222 YP_916807 1000 Rhodobacter sphaeroides ATCC 17025 YP_001166875 283 Rhodobacter sphaeroides 2.4.1 YP_351928 998 Rhodobacter sphaeroides ATCC 17029 YP_001042415 835 Hyphomonas neptunium ATCC 15444 YP_759761 332 Maricaulis maris MCS10 YP_757463 592 Caulobacter crescentus CB15 NP_422200 852 Caulobacter sp. K31 YP_001686123 1000 Alpha-Proteobacteria 487 Sphingomonas wittichii RW1 YP_001264359 Sphingopyxis alaskensis RB2256 YP_616451 969 Erythrobacter litoralis HTCC2594 YP_457435 409 Novosphingobium aromaticivorans DSM 12444 YP_496193 829 612 Candidatus Pelagibacter ubique HTCC1062 YP_265561 Nitrobacter hamburgensis X14 YP_578831 Methylobacterium sp. 4-46 YP_001769241 327 Methylobacterium extorquens PA1 YP_001640720 1000 Methylobacterium radiotolerans JCM 2831 YP_001752742 297 892 Xanthobacter autotrophicus Py2 YP_001419524 Azorhizobium caulinodans ORS 571 YP_001525875 1000 Parvibaculum lavamentivorans DS-1 YP_001411950 285 Nitrobacter winogradskyi Nb-255 YP_316844 Nitrobacter winogradskyi Nb-255 YP_317379 991 1000 Nitrobacter hamburgensis X14 YP_575616 1000 629 Nitrobacter hamburgensis X14 YP_578651 1000 Rhodopseudomonas palustris CGA009 NP_946185 461 958 Rhodopseudomonas palustris HaA2 YP_488181 779 Rhodopseudomonas palustris BisB5 YP_567954 994 Rhodopseudomonas palustris BisB18 YP_534629 632 Rhodopseudomonas palustris BisA53 YP_783651 849 Bradyrhizobium japonicum USDA 110 NP_767811 383 Bradyrhizobium sp. ORS278 YP_001208524 236 826 Bradyrhizobium sp. BTAi1 YP_001236997 956 Mesorhizobium sp. BNC1 YP_673307 Mesorhizobium loti MAFF303099 NP_107796 515 Sinorhizobium meliloti 1021 NP_385011 343 Sinorhizobium medicae WSM419 YP_001326210 999 Agrobacterium tumefaciens str. C58 NP_353792 641 Rhizobium etli CFN 42 YP_468491 Rhizobium leguminosarum bv. viciae 3841 YP_766633 990 954 Ochrobactrum anthropi ATCC 49188 YP_001369142 Brucella abortus biovar 1 str. 9-941 YP_221246 Brucella melitensis biovar Abortus 2308 YP_413953 1000 645 Brucella ovis ATCC 25840 YP_001258486 999 Brucella melitensis 16M NP_540382 Brucella suis ATCC 23445 YP_001627153 179 Brucella suis 1330 NP_697496 596 Brucella canis ATCC 23365 YP_001592327 282 Dechloromonas aromatica RCB YP_284689 Chromobacterium violaceum ATCC 12472 NP_900270 Azoarcus sp. EbN1 YP_159414 Azoarcus sp. BH72 YP_934805 969 Bordetella parapertussis 12822 NP_886335 Bordetella bronchiseptica RB50 NP_891206 849 1000 Bordetella petrii DSM 12804 YP_001628771 1000 Bordetella petrii DSM 12804 YP_001630971 954 Bordetella pertussis Tohama I NP_882246 650 996 Bordetella parapertussis 12822 NP_886371 1000 Bordetella bronchiseptica RB50 NP_891363 920 Polynucleobacter sp. QLW-P1DMWA-1 YP_001156715 Polynucleobacter necessarius STIR1 YP_001798332 1000 917 Ralstonia solanacearum GMI1000 NP_518484 195 Ralstonia metallidurans CH34 YP_582417 661 1000 Ralstonia eutropha JMP134 YP_294541 956 967 509 Ralstonia eutropha H16 YP_724862 252 Herminiimonas arsenicoxydans YP_001101152 628 666 773 Janthinobacterium sp. Marseille YP_001354841 632 Methylibium petroleiphilum PM1 YP_001022368 817 426 Acidovorax sp. JS42 YP_987725 389 Delftia acidovorans SPH-1 YP_001562703 90 Acidovorax avenae subsp. citrulli AAC00-1 YP_972223 503 Verminephrobacter eiseniae EF01-2 YP_996163 990 Leptothrix cholodnii SP-6 YP_001792838 221 Rhodoferax ferrireducens T118 YP_522942 Polaromonas sp. JS666 YP_548095 Beta-Proteobacteria 1000 Polaromonas naphthalenivorans CJ2 YP_981117 992 Acidovorax avenae subsp. citrulli AAC00-1 YP_971882 355 334 453 Burkholderia pseudomallei 1710b YP_336750 Burkholderia pseudomallei 668 YP_001061143 590 Burkholderia pseudomallei K96243 YP_110109 675 Burkholderia pseudomallei 1106a YP_001074155 846 638 Burkholderia xenovorans LB400 YP_556882 Burkholderia vietnamiensis G4 YP_001120772 483 176 Burkholderia ambifaria MC40-6 YP_001809456 969 300 Burkholderia multivorans ATCC 17616 YP_001578649 401 Burkholderia sp. 383 YP_370413 335 Burkholderia cenocepacia AU 1054 YP_622106 Burkholderia ambifaria AMMD YP_774791 737 Burkholderia cenocepacia HI2424 YP_836489 Burkholderia cenocepacia MC0-3 YP_001766138 926 49 Burkholderia thailandensis E264 YP_440985 62 Burkholderia mallei ATCC 23344 YP_104673 69 Burkholderia pseudomallei K96243 YP_107079 89 Burkholderia mallei NCTC 10229 YP_001027406 130 Burkholderia pseudomallei 1710b YP_332087 712 Burkholderia mallei NCTC 10247 YP_001082371 Burkholderia pseudomallei 668 YP_001057543 1000 Burkholderia mallei SAVP1 YP_991520 535 Burkholderia pseudomallei 1106a YP_001064791 1000 Nitrosospira multiformis ATCC 25196 YP_410884 198 Nitrosospira multiformis ATCC 25196 YP_412465 Nitrosomonas europaea ATCC 19718 NP_841089 Nitrosomonas eutropha C91 YP_748573 341 1000 Thiobacillus denitrificans ATCC 25259 YP_314084 357 Nitrosococcus oceani ATCC 19707 YP_345017 356 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 YP_096890 734 Legionella pneumophila str. Paris YP_125263 Legionella pneumophila str. Lens YP_128137 978 Legionella pneumophila str. Corby YP_001252428 456 Saccharophagus degradans 2-40 YP_525513 601 978 Hahella chejuensis KCTC 2396 YP_431395 448 Marinobacter aquaeolei VT8 YP_957357 837 1000 Pseudomonas stutzeri A1501 YP_001174628 820 Pseudomonas mendocina ymP_YP_001185649 477 Pseudomonas aeruginosa PA7 YP_001345577 828 Pseudomonas aeruginosa PAO1 NP_248796 822 Pseudomonas aeruginosa UCBPP-PA14 YP_788264 767 Pseudomonas fluorescens Pf-5 YP_257214 344 365 Pseudomonas fluorescens PfO-1 YP_345811 255 Pseudomonas putida W619 YP_001746998 797 Pseudomonas putida KT2440 NP_742274 Pseudomonas putida F1 YP_001265479 1000 Pseudomonas entomophila L48 YP_605868 154 Pseudomonas putida GB-1 YP_001666370 Candidatus Ruthia magnifica str. Cm Calyptogena magnifica YP_903309 305 Candidatus Vesicomyosocius okutanii HA YP_001218898 674 999 Methylococcus capsulatus str. Bath YP_113374 1000 Alkalilimnicola ehrlichei MLHE-1 YP_741139 965 Xanthomonas campestris pv. campestris str. ATCC 33913 NP_639177 192 651 Xanthomonas campestris pv. campestris str. 8004 YP_244964 805 Xanthomonas axonopodis pv. citri str. 306 NP_644193 Xanthomonas campestris pv. vesicatoria str. 85-10 YP_365736 Gamma-Proteobacteria Xanthomonas oryzae pv. oryzae KACC10331 YP_202779 477 Xanthomonas oryzae pv. oryzae MAFF 311018 YP_452948 915 958 Alcanivorax borkumensis SK2 YP_693619 707 Pseudoalteromonas atlantica T6c YP_663798 Pseudoalteromonas haloplanktis TAC125 YP_341349 344 Psychromonas ingrahamii 37 YP_944025 355 Photobacterium profundum SS9 YP_128409 1000 Colwellia psychrerythraea 34H YP_267002 183 769 Idiomarina loihiensis L2TR YP_154651 994 Vibrio parahaemolyticus RIMD 2210633 NP_800047 Vibrio harveyi ATCC BAA-1116 YP_001448390 526 Vibrio vulnificus CMCP6 NP_762523 195 425 Vibrio vulnificus YJ016 NP_937171 65 Shewanella halifaxensis HAW-EB4 YP_001672492 166 Shewanella amazonensis SB2B YP_929356 881 179 Shewanella loihica PV-4 YP_001092255 Shewanella sediminis HAW-EB3 YP_001471938 Shewanella pealeana ATCC 700345 YP_001503845 482 Shewanella woodyi ATCC 51908 YP_001758573 376 511 Shewanella denitrificans OS217 YP_564516 285 Shewanella frigidimarina NCIMB 400 YP_748958 806 Shewanella sp. MR-7 YP_739899 998 Shewanella sp. ANA-3 YP_871616 322 Shewanella sp. MR-4 YP_735912 555 Shewanella sp. W3-18-1 YP_961539 161 Shewanella putrefaciens CN-32 YP_001185289 157 Shewanella baltica OS195 YP_001556730 Shewanella baltica OS185 YP_001368360 1000 Shewanella oneidensis MR-1 NP_720123 Shewanella baltica OS155 YP_001048556 Tropheryma whipplei str. Twist NP_787372 Tropheryma whipplei TW08 27 NP_789455 Leifsonia xyli subsp. xyli str. CTCB07 YP_062417 Clavibacter michiganensis subsp. michiganensis NCPPB 382 YP_001222583 948 1000 Clavibacter michiganensis subsp. sepedonicus YP_001710118 1000 Renibacterium salmoninarum ATCC 33209 YP_001624733 Arthrobacter sp. FB24 YP_831696 996 335 Arthrobacter aurescens TC1 YP_947955 932 Kineococcus radiotolerans SRS30216 YP_001362986 Propionibacterium acnes KPA171202 YP_055417 Acidothermus cellulolyticus 11B YP_872249 273 374 Acidothermus cellulolyticus 11B YP_872716 1000 Thermobifida fusca YX YP_289753 20 Thermobifida fusca YX YP_288942 939 235 Thermobifida fusca YX YP_289077 837 Streptomyces coelicolor A32 NP_626411 163 Streptomyces avermitilis MA-4680 NP_827224 999 Streptomyces coelicolor A32 NP_631290 298 Streptomyces avermitilis MA-4680 NP_827713 400 213 Nocardioides sp. JS614 YP_919310 Nocardioides sp. JS614 YP_924329 999 Frankia sp. CcI3 YP_481589 Frankia sp. EAN1pec YP_001506146 Frankia sp. CcI3 YP_481112 825 950 Frankia alni ACN14a YP_714342 992 Frankia sp. EAN1pec YP_001505257 9 1000 Frankia alni ACN14a YP_716216 802 Frankia alni ACN14a YP_715300 896 Frankia sp. CcI3 YP_482202 724 Frankia sp. CcI3 YP_482900 663 297 Salinispora tropica CNB-440 YP_001157943 Salinispora arenicola CNS-205 YP_001535885 1000 Salinispora tropica CNB-440 YP_001158972 455 Salinispora arenicola CNS-205 YP_001537144 1000 Saccharopolyspora erythraea NRRL 2338 YP_001103438 Saccharopolyspora erythraea NRRL 2338 YP_001109127 903 Rhodococcus sp. RHA1 YP_707487 534 Rhodococcus sp. RHA1 YP_704173 875 Rhodococcus sp. RHA1 YP_706379 506 Actinobacteria Nocardia farcinica IFM 10152 YP_117403 252 Nocardia farcinica IFM 10152 YP_120507 614 652 193 Corynebacterium jeikeium K411 YP_250256 Corynebacterium urealyticum DSM 7109 YP_001800872 881 Corynebacterium diphtheriae NCTC 13129 NP_940201 1000 Corynebacterium efficiens YS-314 NP_739028 999 Corynebacterium glutamicum R YP_001139341 1000 Corynebacterium glutamicum ATCC 13032 NP_601724 146 1000 Corynebacterium glutamicum ATCC 13032 YP_226765 825 Mycobacterium abscessus YP_001703352 Mycobacterium abscessus YP_001701786 Mycobacterium ulcerans Agy99 YP_905358 86 Mycobacterium smegmatis str. MC2 155 YP_888712 926 Mycobacterium avium subsp. paratuberculosis K-10 NP_962025 Mycobacterium avium 104 YP_883070 1000 165 Mycobacterium ulcerans Agy99 YP_905820 241 Mycobacterium leprae TN NP_302190 428 Mycobacterium tuberculosis H37Ra YP_001284419 294 565 Mycobacterium tuberculosis F11 YP_001288988 816 Mycobacterium bovis BCG str. Pasteur 1173P2 YP_979151 999 Mycobacterium tuberculosis H37Rv NP_217559 542 85 Mycobacterium tuberculosis CDC1551 NP_337644 589 Mycobacterium bovis AF2122 97 NP_856714 717 Mycobacterium vanbaalenii PYR-1 YP_956381 Mycobacterium gilvum PYR-GCK YP_001132466 997 Mycobacterium sp. KMS YP_937889 Mycobacterium sp. JLS YP_001070112 996 Mycobacterium sp. MCS YP_639017 434 203 934 Mycobacterium sp. JLS YP_001071718 Mycobacterium sp. MCS YP_640601 1000 Mycobacterium sp. KMS YP_939485 828 535 Mycobacterium abscessus YP_001704119 Mycobacterium gilvum PYR-GCK YP_001135534 109 Mycobacterium vanbaalenii PYR-1 YP_952903 655 Mycobacterium sp. KMS YP_935664 202 Mycobacterium gilvum PYR-GCK YP_001136592 806 Mycobacterium vanbaalenii PYR-1 YP_954495 984 Mycobacterium gilvum PYR-GCK YP_001134083 523 Mycobacterium gilvum PYR-GCK YP_001136626 469 Nitrosospira multiformis ATCC 25196 YP_411159 Burkholderia xenovorans LB400 YP_555356 Burkholderia xenovorans LB400 YP_558837 1000 1000 Burkholderia pseudomallei 1106a YP_001065064 Burkholderia pseudomallei K96243 YP_107348 676 1000 Burkholderia pseudomallei 668 YP_001057822 792 Burkholderia pseudomallei 1710b YP_332357 405 1000 Burkholderia multivorans ATCC 17616 YP_001585463 Burkholderia vietnamiensis G4 YP_001115017 981 Burkholderia ambifaria AMMD YP_778451 731 Burkholderia ambifaria MC40-6 YP_001816273 1000 Burkholderia cenocepacia MC0-3 YP_001773760 409 969 Burkholderia cenocepacia HI2424 YP_840161 1000 Burkholderia cenocepacia AU 1054 YP_621172 937 Burkholderia xenovorans LB400 YP_555443 Solibacter usitatus Ellin6076 YP_828106 611 Mesorhizobium loti MAFF303099 NP_109481 880 Rhizobium etli CFN 42 YP_471835 1000 Sinorhizobium medicae WSM419 YP_001314880 947 Proteobacteria III Gamma-Proteobacteria Beta-Proteobacteria Alpha-Proteobacteria Acidobacteria PVC Methylobacterium extorquens PA1 YP_001637594 1000 Methylobacterium sp. 4-46 YP_001769836 1000 1000 Methylobacillus flagellatus KT YP_545557 Dinoroseobacter shibae DFL 12 YP_001542100 Nitrosococcus oceani ATCC 19707 YP_343768 Rhodopirellula baltica SH 1 NP_866086 359 1000 Rhodobacter sphaeroides ATCC 17025 YP_001167902 573 Rhodobacter sphaeroides 2.4.1 YP_353192 1000 Rhodobacter sphaeroides ATCC 17029 YP_001043635 967 925 1000 Azoarcus sp. EbN1 YP_159601 Bordetella petrii DSM 12804 YP_001631825 629 Mesorhizobium sp. BNC1 YP_675332 993 Sinorhizobium meliloti 1021 NP_437488 785 1000 Sinorhizobium medicae WSM419 YP_001313492 1000 599 Pseudomonas stutzeri A1501 YP_001172366 Pseudomonas mendocina ymP_YP_001187757 835 Azoarcus sp. EbN1 YP_157109 1000 Azoarcus sp. BH72 YP_933261 584 Nitrobacter winogradskyi Nb-255 YP_318920 991 Parvibaculum lavamentivorans DS-1 YP_001411844 607 Rhodobacter sphaeroides ATCC 17025 YP_001169842 999 Rhodobacter sphaeroides 2.4.1 YP_354614 1000 Rhodobacter sphaeroides ATCC 17029 YP_001045676 1000 368 Rhodopseudomonas palustris HaA2 YP_483778 Rhodopseudomonas palustris BisB18 YP_533702 1000 Rhodopseudomonas palustris BisA53 YP_782773 991 Herpetosiphon aurantiacus ATCC 23779 YP_001542885 Cloroflexi Roseiflexus sp. RS-1 YP_001276593 878 Roseiflexus castenholzii DSM 13941 YP_001433624 1000 Acidobacteria Solibacter usitatus Ellin6076 YP_828774 Symbiobacterium thermophilum IAM 14863 YP_075926 Exiguobacterium sibiricum 255-15 YP_001814456 Bacillus halodurans C-125 NP_243480 291 Bacillus clausii KSM-K16 YP_175888 955 1000 Oceanobacillus iheyensis HTE831 NP_692359 729 Lysinibacillus sphaericus C3-41 YP_001697134 Bacillus licheniformis ATCC 14580 YP_078884 398 660 Bacillus licheniformis ATCC 14580 YP_091296 1000 Bacillus pumilus SAFR-032 YP_001486625 571 997 Bacillus subtilis subsp. subtilis str. 168 NP_389373 515 Bacillus amyloliquefaciens FZB42 YP_001421070 996 Firmicutes II 706 Geobacillus kaustophilus HTA426 YP_146936 Geobacillus thermodenitrificans NG80-2 YP_001125071 1000 Bacillus cereus subsp. cytotoxis NVH 391-98 YP_001375874 854 771 Bacillus cereus ATCC 10987 NP_980285 Bacillus cereus ATCC 14579 NP_833662 1000 Bacillus weihenstephanensis KBAB4 YP_001646566 381 569 Bacillus anthracis str. Sterne YP_030105 543 Bacillus cereus E33L YP_085284 593 Bacillus thuringiensis str. Al Hakam YP_896311 730 Bacillus thuringiensis serovar konkukian str. 97-27 YP_038005 419 Bacillus anthracis str. Ames NP_846391 449 Bacillus anthracis str. Ames Ancestor YP_020800 593 Lysinibacillus sphaericus C3-41 YP_001699583 Oceanobacillus iheyensis HTE831 NP_693175 963 Lysinibacillus sphaericus C3-41 YP_001698546 801 Bacillus cereus subsp. cytotoxis NVH 391-98 YP_001373933 916 Bacillus cereus ATCC 10987 NP_977096 1000 Bacillus cereus ATCC 14579 NP_830510 979 Bacillus weihenstephanensis KBAB4 YP_001643510 779 345 Bacillus cereus E33L YP_082219 181 Bacillus thuringiensis str. Al Hakam YP_893531 496 Bacillus anthracis str. Sterne YP_026945 53 Bacillus thuringiensis serovar konkukian str. 97-27 YP_034958 Bacillus anthracis str. Ames NP_843229 789 Bacillus anthracis str. Ames Ancestor YP_017332 515 Geobacillus kaustophilus HTA426 YP_149311 Geobacillus thermodenitrificans NG80-2 YP_001127472 997 Bacillus halodurans C-125 NP_242931 Bacillus clausii KSM-K16 YP_175632 1000 Listeria monocytogenes EGD-e NP_463547 Listeria innocua Clip11262 NP_469361 1000 218 Listeria monocytogenes str. 4b F2365 YP_012629 133 Listeria welshimeri serovar 6b str. SLCC5334 YP_848218 801 463 Bacillus subtilis subsp. subtilis str. 168 NP_391695 Firmicutes I Bacillus amyloliquefaciens FZB42 YP_001423102 999 Bacillus pumilus SAFR-032 YP_001488673 808 Bacillus licheniformis ATCC 14580 YP_081116 597 Bacillus licheniformis ATCC 14580 YP_093545 1000 Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 YP_301821 1000 Staphylococcus haemolyticus JCSC1435 YP_253817 Staphylococcus epidermidis ATCC 12228 NP_764313 1000 Staphylococcus epidermidis RP62A YP_188230 1000 Staphylococcus aureus subsp. aureus COL YP_185933 838 Staphylococcus aureus subsp. aureus MW2 NP_645760 Staphylococcus aureus RF122 YP_416411 1000 Staphylococcus aureus subsp. aureus USA300 YP_493660 159 Staphylococcus aureus subsp. aureus NCTC 8325 YP_499553 810 Staphylococcus aureus subsp. aureus USA300 TCH1516 YP_001574903 219 Staphylococcus aureus subsp. aureus str. Newman YP_001331963 100 Staphylococcus aureus subsp. aureus JH1 YP_001316283 285 Staphylococcus aureus subsp. aureus Mu3 YP_001441642 138 Staphylococcus aureus subsp. aureus JH9 YP_001246495 343 Staphylococcus aureus subsp. aureus Mu50 NP_371584 169 Staphylococcus aureus subsp. aureus N315 NP_374179 368 Staphylococcus aureus subsp. aureus MSSA476 YP_043120 211 Staphylococcus aureus subsp. aureus MRSA252 YP_040448 614 Acidiphilium cryptum JF-5 YP_001234229 Candidatus Carsonella ruddii PV YP_802566 Candidatus Protochlamydia amoebophila UWE25 YP_008189 Bartonella bacilliformis KC583 YP_989523 78 999 Bartonella tribocorum CIP_105476 YP_001608617 1000 Bartonella henselae str. Houston-1 YP_032982 851 Bartonella quintana str. Toulouse YP_031835 773 447 Nitrosomonas eutropha C91 YP_746933 Mesorhizobium sp. BNC1 YP_676071 313 Nitrobacter winogradskyi Nb-255 YP_317387 855 Nitrobacter hamburgensis X14 YP_578641 1000 Legionella pneumophila str. Paris YP_122635 106 Coxiella burnetii Dugway 5J108-111 YP_001424381 998 Coxiella burnetii RSA 331 YP_001596689 1000 Coxiella burnetii RSA 493 NP_820041 742 Bradyrhizobium japonicum USDA 110 NP_769355 Bradyrhizobium sp. ORS278 YP_001206809 1000 Bradyrhizobium sp. BTAi1 YP_001239191 998 Ochrobactrum anthropi ATCC 49188 YP_001368609 Brucella melitensis 16M NP_540817 1000 Brucella ovis ATCC 25840 YP_001258090 29 56 1000 Brucella suis ATCC 23445 YP_001626723 657 Brucella suis 1330 NP_697085 502 Brucella canis ATCC 23365 YP_001591920 466 181 Methylobacterium extorquens PA1 YP_001641776 Methylobacterium radiotolerans JCM 2831 YP_001754410 955 Methylobacterium sp. 4-46 YP_001772457 Silicibacter sp. TM1040 YP_614279 432 731 Rhizobium etli CFN 42 YP_472195 Rhizobium leguminosarum bv. viciae 3841 YP_771074 1000 Agrobacterium tumefaciens str. C58 NP_353177 770 166 Sinorhizobium meliloti 1021 NP_437856 30 602 Sinorhizobium medicae WSM419 YP_001313108 999 Caulobacter crescentus CB15 NP_420580 407 Alcanivorax borkumensis SK2 YP_693756 Methylibium petroleiphilum PM1 YP_001020937 138 Bordetella parapertussis 12822 NP_883412 351 Bordetella bronchiseptica RB50 NP_887855 1000 235 Bordetella pertussis Tohama I NP_881338 692 759 Bordetella petrii DSM 12804 YP_001632007 Ralstonia eutropha JMP134 YP_299083 473 Ralstonia metallidurans CH34 YP_587737 938 383 Ralstonia eutropha H16 YP_729182 987 Acidovorax avenae subsp. citrulli AAC00-1 YP_970574 Acidovorax sp. JS42 YP_986993 994 Delftia acidovorans SPH-1 YP_001565074 971 Herminiimonas arsenicoxydans YP_001100944 196 Janthinobacterium sp. Marseille YP_001354329 990 Mesorhizobium loti MAFF303099 NP_107274 Sphingopyxis alaskensis RB2256 YP_616553 220 607 Paracoccus denitrificans PD1222 YP_918863 43 969 Azorhizobium caulinodans ORS 571 YP_001525015 817 Bradyrhizobium japonicum USDA 110 NP_766790 625 Rhodopseudomonas palustris HaA2 YP_483863 818 Rhodopseudomonas palustris BisB5 YP_567735 910 Bradyrhizobium sp. ORS278 YP_001203834 574 Bradyrhizobium sp. BTAi1 YP_001238127 956 Acinetobacter sp. ADP1 YP_047021 Acinetobacter baumannii ATCC 17978 YP_001085196 1000 Acinetobacter baumannii SDF YP_001706978 987 Acinetobacter baumannii AYE YP_001713301 575 Francisella tularensis subsp. novicida U112 YP_897860 Francisella tularensis subsp. holarctica YP_512987 1000 Francisella tularensis subsp. holarctica FTA YP_001427640 935 Francisella tularensis subsp. holarctica OSU18 YP_762853 361 Francisella tularensis subsp. tularensis FSC198 YP_666464 381 Francisella tularensis subsp. tularensis SCHU S4 YP_169332 760 Francisella tularensis subsp. tularensis WY96-3418 YP_001122595 555 Chromohalobacter salexigens DSM 3043 YP_573011 Aeromonas hydrophila subsp. hydrophila ATCC 7966 YP_857449 80 Aeromonas salmonicida subsp. salmonicida A449 YP_001142711 1000 Vibrio parahaemolyticus RIMD 2210633 NP_800138 244 Vibrio harveyi ATCC BAA-1116 YP_001447623 1000 Sodalis glossinidius str. morsitans YP_454346 Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis NP_871151 276 Proteobacteria I (Gamma-Proteobacteria) (Beta-Proteobacteria) (Alpha-Proteobacteria) (PVC) 938 Baumannia cicadellinicola str. Hc Homalodisca coagulata YP_588718 750 Candidatus Blochmannia floridanus NP_878541 853 246 Candidatus Blochmannia pennsylvanicus str. BPEN YP_277755 410 982 Pectobacterium atrosepticum SCRI1043 YP_049248 Photorhabdus luminescens subsp. laumondii TTO1 NP_931081 181 Serratia proteamaculans 568 YP_001477321 94 606 Yersinia enterocolitica subsp. enterocolitica 8081 YP_001007324 Yersinia pestis Pestoides F YP_001164135 923 Yersinia pseudotuberculosis IP_31758 YP_001402059 616 978 Yersinia pestis KIM NP_668350 Yersinia pestis Angola YP_001607427 1000 375 130 Yersinia pseudotuberculosis YPIII YP_001721964 939 Yersinia pestis CO92 NP_406640 95 Yersinia pestis biovar Microtus str. 91001 NP_992154 317 Yersinia pseudotuberculosis IP_32953 YP_069492 724 Yersinia pestis Antiqua YP_652566 818 Yersinia pestis Nepal516 YP_646858 982 Buchnera aphidicola str. APS Acyrthosiphon pisum NP_240282 Buchnera aphidicola str. Sg Schizaphis graminum NP_660787 997 Buchnera aphidicola str. BP_Baizongia pistaciae NP_778021 454 Buchnera aphidicola str. Cc Cinara cedri YP_802843 384 Enterobacter sakazakii ATCC BAA-894 YP_001438936 142 Citrobacter koseri ATCC BAA-895 YP_001454272 Klebsiella pneumoniae subsp. pneumoniae MGH 78578 YP_001334075 716 Enterobacter sp. 638 YP_001175633 732 910 Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7 YP_001589333 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 YP_215471 628 20 Salmonella typhimurium LT2 NP_459438 968 490 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 NP_806148 425 Salmonella enterica subsp. enterica serovar Typhi str. CT18 NP_455039 103 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 YP_151477 168 Salmonella enterica subsp. arizonae serovar 62 YP_001571493 569 432 Shigella boydii Sb227 YP_406866 Escherichia coli O157 H7 EDL933 NP_286173 Escherichia coli str. K-12 substr. MG1655 NP_414965 150 Escherichia coli O157 H7 str. Sakai NP_308512 71 1000 Escherichia coli str. K12 substr. W3110 AP_001081 64 Escherichia coli UTI89 YP_539487 73 Shigella sonnei Ss046 YP_309425 269 434 Escherichia coli CFT073 NP_752476 Escherichia coli DH10B YP_001729337 42 Escherichia coli SECEC SMS-3-5 YP_001742572 341 Escherichia coli E24377A YP_001461617 27 Escherichia coli HS YP_001457274 281 Escherichia coli APEC O1 YP_851604 140 Escherichia coli 536 YP_668419 295 Pseudomonas fluorescens Pf-5 YP_261816 Granulibacter bethesdensis CGDNIH1 YP_745096 Gluconobacter oxydans 621H YP_192306 Gluconacetobacter diazotrophicus PAl 5 YP_001602279 1000 Burkholderia vietnamiensis G4 YP_001120648 389 Burkholderia thailandensis E264 YP_442319 1000 Burkholderia pseudomallei K96243 YP_108972 969 Burkholderia pseudomallei 1106a YP_001067024 887 785 Burkholderia pseudomallei 668 YP_001059739 342 Burkholderia pseudomallei 1710b YP_334218 457 Burkholderia mallei SAVP1 YP_993718 414 Burkholderia mallei NCTC 10229 YP_001028824 982 Burkholderia mallei NCTC 10247 YP_001081265 524 948 51 Burkholderia vietnamiensis G4 YP_001119810 Burkholderia multivorans ATCC 17616 YP_001579395 Burkholderia ambifaria AMMD YP_773996 794 Burkholderia ambifaria MC40-6 YP_001808673 401 796 Burkholderia sp. 383 YP_369613 88 Burkholderia cenocepacia MC0-3 YP_001765372 263 924 Burkholderia cenocepacia AU 1054 YP_625845 985 Burkholderia cenocepacia HI2424 YP_835714 508 Burkholderia xenovorans LB400 YP_553679 Burkholderia thailandensis E264 YP_438680 Burkholderia pseudomallei 668 YP_001063707 826 Burkholderia pseudomallei 1710b YP_336150 521 859 57 Burkholderia pseudomallei K96243 YP_111902 825 Burkholderia pseudomallei 1106a YP_001076601 753 993 Burkholderia mallei SAVP1 YP_990966 Burkholderia mallei ATCC 23344 YP_105022 644 Burkholderia mallei NCTC 10229 YP_001025367 68 Burkholderia mallei NCTC 10247 YP_001077431 481 Methylobacillus flagellatus KT YP_545403 Bordetella petrii DSM 12804 YP_001631310 Bordetella bronchiseptica RB50 NP_887830 957 Bordetella parapertussis 12822 NP_883388 1000 Bordetella pertussis Tohama I NP_881514 688 109 958 Ralstonia eutropha JMP134 YP_298772 Ralstonia metallidurans CH34 YP_587920 571 Ralstonia solanacearum GMI1000 NP_519980 1000 Ralstonia eutropha H16 YP_726142 972 478 Xylella fastidiosa 9a5c NP_298678 Xylella fastidiosa Temecula1 NP_778846 1000 Xylella fastidiosa M12 YP_001775363 978 Xanthomonas oryzae pv. oryzae KACC10331 YP_200269 995 Xanthomonas oryzae pv. oryzae MAFF 311018 YP_450545 1000 Xanthomonas axonopodis pv. citri str. 306 NP_641594 78 998 Xanthomonas campestris pv. vesicatoria str. 85-10 YP_363039 998 Xanthomonas campestris pv. campestris str. ATCC 33913 NP_636534 693 Xanthomonas campestris pv. campestris str. 8004 YP_244149 999 Ralstonia solanacearum GMI1000 NP_521037 Ralstonia metallidurans CH34 YP_583104 560 Ralstonia eutropha JMP134 YP_295206 1000 Ralstonia eutropha H16 YP_725581 740 Pseudomonas aeruginosa PAO1 NP_250009 Pseudomonas aeruginosa PA7 YP_001349426 1000 109 Pseudomonas aeruginosa UCBPP-PA14 YP_791927 722 Pseudomonas putida W619 YP_001751224 Pseudomonas entomophila L48 YP_606676 631 Pseudomonas putida GB-1 YP_001667096 1000 Pseudomonas putida KT2440 NP_742974 998 741 Pseudomonas putida F1 YP_001266182 799 1000 Pseudomonas fluorescens Pf-5 YP_262115 Pseudomonas fluorescens PfO-1 YP_350375 1000 Pseudomonas syringae pv. tomato str. DC3000 NP_791153 535 Pseudomonas syringae pv. syringae B728a YP_234234 775 998 Pseudomonas syringae pv. phaseolicola 1448A YP_273477 993 Chromobacterium violaceum ATCC 12472 NP_903665 Marinomonas sp. MWYL1 YP_001338967 374 Pseudoalteromonas haloplanktis TAC125 YP_340728 967 Pseudoalteromonas atlantica T6c YP_660871 612 Shewanella frigidimarina NCIMB 400 YP_748924 817 Shewanella woodyi ATCC 51908 YP_001758825 899 Shewanella loihica PV-4 YP_001092498 524 Shewanella sp. W3-18-1 YP_961501 Shewanella putrefaciens CN-32 YP_001185364 573 1000 Shewanella baltica OS185 YP_001368398 556 Shewanella baltica OS195 YP_001556769 1000 Shewanella sp. ANA-3 YP_871655 762 Shewanella sp. MR-7 YP_739949 997 Shewanella sp. MR-4 YP_735944 843 1000 999 746 1000 923 1000 1000 877 1000 1000 820 587 510 1000 1000 914 679 982 997 1000 1000 1000 997 881 409 505 429 874 1000 841 908 1000 939 937 626 551 1000 701 518 1000 739 1000 746 362 1000 561 51 812 50 33 690 971 807 218 Suppl. Mat. 5 0.1

5. 0.1 A B Arcobacter butzleri RM4018 YP_001490279 Sulfolobus solfataricus P2 NP_342994 Caldivirga maquilingensis IC-167 YP_001540124 Pyrobaculum arsenaticum DSM 13514 YP_001152749 715 Pyrobaculum aerophilum str. IM2 NP_560853 978 Pyrobaculum calidifontis JCM 11548 YP_001056790 Desulfitobacterium hafniense Y51 YP_517398 659 Methylococcus capsulatus str. Bath YP_114815 Nitratiruptor sp. SB155-2 YP_001357257 1000 Sulfurimonas denitrificans DSM 1251 YP_394493 992 Sulfurovum sp. NBC37-1 YP_001357561 1000 997 Anaeromyxobacter sp. Fw109-5 YP_001379942 Bdellovibrio bacteriovorus HD100 NP_969401 393 Nitrosospira multiformis ATCC 25196 YP_411950 891 Thiobacillus denitrificans ATCC 25259 YP_314581 1000 Acidovorax sp. JS42 YP_987627 996 587 Shewanella denitrificans OS217 YP_562986 Magnetococcus sp. MC-1 YP_864053 120 Leptothrix cholodnii SP-6 YP_001790501 Azoarcus sp. BH72 YP_934592 979 228 Dechloromonas aromatica RCB YP_286391 793 Azoarcus sp. EbN1 YP_157126 545 Thiobacillus denitrificans ATCC 25259 YP_314319 542 155 801 Photobacterium profundum SS9 YP_132726 Colwellia psychrerythraea 34H YP_267351 Hahella chejuensis KCTC 2396 YP_435539 248 Marinobacter aquaeolei VT8 YP_960376 211 Pseudomonas stutzeri A1501 YP_001173991 Bordetella petrii DSM 12804 YP_001632665 252 980 Pseudomonas aeruginosa UCBPP-PA14 YP_788694 559 Pseudomonas aeruginosa PAO1 NP_249215 993 997 Pseudomonas aeruginosa PA7 YP_001346020 614 Alkalilimnicola ehrlichei MLHE-1 YP_742950 Nitrosococcus oceani ATCC 19707 YP_343846 658 Nitrosomonas europaea ATCC 19718 NP_842019 1000 Nitrosomonas eutropha C91 YP_746761 Paracoccus denitrificans PD1222 YP_916266 711 Rhodobacter sphaeroides ATCC 17025 YP_001167177 Rhodobacter sphaeroides 2.4.1 YP_353400 999 1000 Rhodobacter sphaeroides ATCC 17029 YP_001043844 1000 Roseobacter denitrificans OCh 114 YP_681875 481 985 Silicibacter pomeroyi DSS-3 YP_165045 498 Dinoroseobacter shibae DFL 12 YP_001534518 585 Magnetospirillum magneticum AMB-1 YP_422307 Rhizobium etli CFN 42 YP_473132 Sinorhizobium meliloti 1021 NP_435940 582 Sinorhizobium medicae WSM419 YP_001314819 966 Agrobacterium tumefaciens str. C58 NP_356267 1000 Rhodopseudomonas palustris CGA009 NP_946806 Rhodopseudomonas palustris BisA53 YP_779559 886 Bradyrhizobium japonicum USDA 110 NP_769855 333 886 Bradyrhizobium sp. ORS278 YP_001203888 999 Bradyrhizobium sp. BTAi1 YP_001238182 991 531 Ochrobactrum anthropi ATCC 49188 YP_001372916 Brucella abortus biovar 1 str. 9-941 YP_223677 Brucella melitensis biovar Abortus 2308 YP_419097 979 715 Brucella melitensis 16M NP_541976 999 Brucella suis 1330 NP_699446 536 Brucella canis ATCC 23365 YP_001594211 716 Brucella suis ATCC 23445 YP_001622088 Legionella pneumophila str. Corby YP_001250986 Legionella pneumophila str. Paris YP_124501 1000 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 YP_096248 533 Legionella pneumophila str. Lens YP_127497 642 1000 Burkholderia thailandensis E264 YP_439142 Burkholderia pseudomallei 668 YP_001063055 Burkholderia pseudomallei 1106a YP_001075999 1000 768 Burkholderia mallei NCTC 10247 YP_001078795 999 Burkholderia mallei NCTC 10229 YP_001024473 Burkholderia mallei ATCC 23344 YP_105512 Burkholderia mallei SAVP1 YP_990155 227 865 708 Haloarcula marismortui ATCC 43049 YP_136806 Halorubrum lacusprofundi ATCC 49239 ZP_02015245 1000 Staphylococcus aureus subsp. aureus MRSA252 YP_039724 Bacillus licheniformis ATCC 14580 YP_079248 Bacillus licheniformis ATCC 14580 YP_091667 1000 1000 Geobacillus kaustophilus HTA426 YP_146611 999 Geobacillus thermodenitrificans NG80-2 YP_001124768 996 520 Geobacter metallireducens GS-15 YP_386423 Anaeromyxobacter dehalogenans 2CP-C YP_466383 Sorangium cellulosum So ce 56 YP_001619234 957 861 Propionibacterium acnes KPA171202 YP_056649 1000 Mycobacterium avium subsp. paratuberculosis K-10 NP_962115 968 Mycobacterium avium 104 YP_883164 998 1000 Mycobacterium sp. KMS YP_937591 779 Mycobacterium sp. JLS YP_001069828 853 1000 Mycobacterium sp. MCS YP_638736 Syntrophobacter fumaroxidans MPOB YP_847042 Anaeromyxobacter dehalogenans 2CP-C YP_464614 833 Thaumarchaeota (0/2) Anaeromyxobacter sp. Fw109-5 YP_001379612 1000 Synechocystis sp. PCC 6803 NP_442983 935 Acaryochloris marina MBIC11017 YP_001514849 1000 Acaryochloris marina MBIC11017 YP_001520798 998 Sorangium cellulosum So ce 56 YP_001613920 Campylobacter curvus 525.92 YP_001407973 Campylobacter concisus 13826 YP_001466413 1000 Mannheimia succiniciproducens MBEL55E YP_087486 925 Actinobacillus succinogenes 130Z YP_001344891 1000 Neisseria gonorrhoeae FA 1090 YP_208344 947 1000 Neisseria meningitidis MC58 NP_274628 1000 1000 Neisseria meningitidis 053442 YP_001599647 871 657 Neisseria meningitidis Z2491 NP_284596 Neisseria meningitidis FAM18 YP_975519 363 350 Psychrobacter sp. PRwf-1 YP_001280413 Acidovorax sp. JS42 YP_984423 Herminiimonas arsenicoxydans YP_001098413 232 531 Sphingomonas wittichii RW1 YP_001265090 906 Hahella chejuensis KCTC 2396 YP_432036 536 Idiomarina loihiensis L2TR YP_154578 403 Pseudoalteromonas haloplanktis TAC125 YP_340908 951 988 Bordetella petrii DSM 12804 YP_001632171 440 Ralstonia metallidurans CH34 YP_585308 811 Ralstonia eutropha H16 NP_942879 854 Ralstonia eutropha JMP134 YP_299247 977 Ralstonia eutropha H16 YP_841835 775 Flavobacterium johnsoniae UW101 YP_001194759 Corynebacterium diphtheriae NCTC 13129 NP_940552 156 Solibacter usitatus Ellin6076 YP_824206 530 Acidobacteria bacterium Ellin345 YP_589443 338 Anaeromyxobacter dehalogenans 2CP-C YP_466923 354 Anaeromyxobacter sp. Fw109-5 YP_001381011 1000 Xanthobacter autotrophicus Py2 YP_001417931 Sphingomonas wittichii RW1 YP_001260078 590 Parvibaculum lavamentivorans DS-1 YP_001412284 997 Shewanella amazonensis SB2B YP_926606 Shewanella loihica PV-4 YP_001092788 Shewanella sediminis HAW-EB3 YP_001475554 1000 Shewanella woodyi ATCC 51908 YP_001759151 448 229 348 Shewanella halifaxensis HAW-EB4 YP_001675756 531 Shewanella frigidimarina NCIMB 400 YP_751928 340 Shewanella sp. W3-18-1 YP_962277 Shewanella putrefaciens CN-32 YP_001184584 247 1000 Shewanella sp. MR-7 YP_736939 460 881 Shewanella sp. ANA-3 YP_868490 546 Shewanella sp. MR-4 YP_735217 666 Rhodoferax ferrireducens T118 YP_523143 Herminiimonas arsenicoxydans YP_001099949 997 1000 Polaromonas naphthalenivorans CJ2 YP_981564 Ralstonia solanacearum GMI1000 NP_523064 1000 Chromobacterium violaceum ATCC 12472 NP_903164 704 Burkholderia thailandensis E264 YP_442345 Burkholderia pseudomallei 668 YP_001059704 1000 766 Burkholderia pseudomallei 1710b YP_334186 Burkholderia pseudomallei 1106a YP_001066989 391 Burkholderia pseudomallei K96243 YP_108946 972 Burkholderia mallei NCTC 10229 YP_001028854 468 377 Burkholderia mallei NCTC 10247 YP_001081235 Burkholderia mallei SAVP1 YP_993685 551 Burkholderia mallei ATCC 23344 YP_102415 869 0.1 Crenarchaeota (5/15) +Korarchaeota (0/1) Arcobacter butzleri RM4018 YP_001490279 ARCHAEA Crenarchaeota (Archaea) 1000 Desulfitobacterium hafniense Epsilon Proteobacteria Gamma Proteobacteria Euryarchaeota (2/35) +Nanoarchaeota (0/1) 659 1000 997 Delta Proteobacteria Beta Proteobacteria Aquificales (0/1) 996 Thermotogales (0/6) Deinococcus/Thermus (0/4) Gamma Proteobacteria Beta Proteobacteria 545 Chloroflexii (0/7) 979 Cyanobacteria (2/32) 993 Gamma Proteobacteria Beta Proteobacteria Alpha Proteobacteria Firmicutes (6/144) 985 Actinobacteria (7/50) Gamma Proteobacteria Beta Proteobacteria Fusobacteria (0/1) BACTERIA Spirochaetes (0/9) Haloarcula marismortui ATCC 43049 708 Halorubrum lacusprofundi ATCC 49239 1000 Acidobacteria (2/2) Firmicutes 1000 PVC (0/15) 520 Delta Proteobacteria Actinobacteria Bacteroidetes/Chlorobi (1/17) 968 957 Epsilon-Proteobacteria (6/19) Delta Proteobacteria Cyanobacteria Delta-Proteobacteria (6/19) 935 972 Delta Proteobacteria Epsilon Proteobacteria Gamma Proteobacteria Alpha Proteobacteria Beta Proteobacteria 1000 Alpha-Proteobacteria (28/83) 925 988 Bacteroidetes Actinobacteria Acidobacteria Delta Proteobacteria Gamma Proteobacteria Alpha Proteobacteria Beta Proteobacteria Beta-Proteobacteria (32/53) Gamma-Proteobacteria (32/157) 620 C 1000 760 Suppl. Mat. 6