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Date of Birth : Makassar/11 Februari 1957 QUALIFICATIONS: 1969 Sekolah Dasar , Surabaya

Curriculum Vitae. Irawan Yusuf. Date of Birth : Makassar/11 Februari 1957 QUALIFICATIONS: 1969 Sekolah Dasar , Surabaya 1972 Sekolah Menengah Pertama , Makassar 1975 Sekolah Menengah Atas , Makassar 1984 Dokter , Fakultas Kedokteran Unhas , Makassar

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Date of Birth : Makassar/11 Februari 1957 QUALIFICATIONS: 1969 Sekolah Dasar , Surabaya

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  1. Curriculum Vitae Irawan Yusuf Date of Birth : Makassar/11 Februari 1957 QUALIFICATIONS: 1969 SekolahDasar, Surabaya 1972 SekolahMenengahPertama, Makassar 1975 SekolahMenengahAtas, Makassar 1984 Dokter, FakultasKedokteranUnhas, Makassar 1992 Ph.D, Hiroshima University, School of Medicine, Japan MEMBERSHIP: 1. AnggotaIkatanDokter Indonesia 2.PengurusMajelisKodeEtikKedokteran Indonesia 2007 3.AnggotaIkatanAhliIlmuFaal Indonesia 4.AnggotaIndonesia Genome Organization

  2. SYSTEM BIOLOGY APPROACH OF AGING PROCESS Implication for Predictive, Preventive, Personalized and Participatory Medicine IRAWAN YUSUF Department of Physiology Faculty of Medicine Hasanuddin University

  3. INTRODUCTION • Aging is a complex process involving defects in various cellular components. • The latest evidence suggests a unifying mechanism for cellular aging that is relevant to the development of common age-related diseases. • Biological system approach will help us to understand, predictive and preventive the aging -related diseases.

  4. Life Expectancy Around the World Oeppen and Vaupel, Science 2002

  5. Changes in Age Structure in Indonesia

  6. Progress in Theory of Aging

  7. WHAT IS SYSTEM BIOLOGY? • As a discipline or field of study in its own right, involving the quantitative analysis of interactions between elements of biological systems. • As a set of multidisciplinary methodologies, in which the emphasis is placed on cycles of iteration between experimental data collection and computational or mathematical modelling. • As an integrative approach, offering an alternative to the ‘reductionist’ approach that is seen by many to have dominated the research agenda for years. • As an organizational phenomenoninvolving the bringing together, in exceptionally close working partnerships, of scientists from diverse disciplinary backgrounds, particularly the biological, engineering and mathematical sciences.

  8. BASIC BIOLOGY OF AGING Stress Response Metabolism Inflammation Aging Genetics Tissue Aging Proliferative Homeostasis

  9. BASIC BIOLOGY OF AGING Chronic Stress Signaling Chaperones Comorbidity ROS Stress Response Immunosenescence Inflammation Metabolism Mitochondria Cytokines IGF / Sirtuins Aging LAG Endocrine Bones & cartilage Epigenetics Genetics Tissue Aging Proliferative Homeostasis Omics Cardiovascular Stress-Induced Secretome Apoptosis

  10. Genomic and Environment Interaction of Aging GENOMIC-PROTEOMIC ENVIRONMENT Genetics Metabolism Cell Cycle Stress response Inflamation Tissue aging INTERMEDIATE PHENOTYPE AGING AND AGING RELATED DISEASES

  11. Systems Biology of Human Aging - Network Model 2010

  12. Model for Aging Related Diseases

  13. Organ-Specific Blood Proteins Will Make the Blood a Window into Health and Disease • Perhaps 50 major organs or cell types--each secreting protein blood molecular fingerprint. • The levels of each protein in a particular blood fingerprint will report the status of that organ. Probably need 10-50 organ-specific proteins per organ. • Need to quantify 500-2500 blood proteins from a droplet of blood. • Key point: changes in the levels of organ-specific markers will assess all diseases or environmental challenges for a particular organ

  14. Predictive, Preventive, Personalizedand Participatory Medicine • Driven by systems approaches to disease and new measurement technologies (nanotechnology) P4 will emerge over the next 10-20 years

  15. SYSTEM BIOLOGY POINT OF VIEW • Current research finding suggests that, as cells age, they tend to accumulate damage. • The rate at which damage arises is dictated, on the average, by genetically determined energy investments in cellular maintenance and repair, at levels optimized to take account of evolutionary trade-offs. • Long-lived organisms make greater investments in cellular maintenance and repair than short-lived organisms, resulting in slower accumulation of damage. • In order to manage the risk presented by damaged cells, particularly the risk of malignancy, organisms have additionally evolved mechanisms, such as tumor suppressor functions, to deal with damaged cells. • In conclusion, there is plasticity in the natural regulation of aging rate.

  16. IMPLEMENTING SYSTEM APPROACH Anti- Inflammatory Inflammation Healthy Nutrition Healthy Life Style Poor Nutrition Stress Environment

  17. THANK YOU

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