CTSA and Clinical and Translational Sciences Institute (CTSI) Where are we? 6/5/08

1. CTSA and Clinical and Translational Sciences Institute (CTSI) Where are we? 6/5/08 Craig J. McClain, M.D., Professor Division of Gastroenterology/Hepatology Departments of Medicine, Pharmacology and Toxicology Associate VP for Translational Research

2. 1st Round CTSA Awardees Columbia University Health Sciences Duke University Mayo Clinic College of Medicine Oregon Health & Science University Rockefeller University University of California, Davis University of California, San Francisco University of Pennsylvania University of Pittsburgh University of Rochester University of Texas Health Science Center at Houston Yale University

3. 2nd Round CTSA Awardees • Case Western Reserve University (Cleveland, Ohio) • Emory University (Atlanta, Ga.), partnering with Morehouse School of Medicine • Johns Hopkins University (Baltimore, Md.) • University of Chicago (Chicago, Ill.) • University of Iowa (Iowa City, Iowa) • University of Michigan (Ann Arbor, Mich.) • University of Texas Southwestern Medical Center (Dallas, Texas) • University of Washington (Seattle, Wash.) • University of Wisconsin (Madison, Wis.) • Vanderbilt University (Nashville, Tenn.), partnering with Meharry Medical College • Washington University (St. Louis, Mo.) • Weill Cornell Medical College (New York, N.Y.), partnering with Hunter College

4. 3rd Round 5/2008 Albert Einstein College of Medicine of Yeshiva University Boston University Harvard University Indiana University School of Medicine Northwestern University Ohio State University Scripps Research Institute Stanford University Tufts University The University of Alabama at Birmingham University of Colorado Denver University of North Carolina at Chapel Hill University of Texas Health Science Center at San Antonio University of Utah

5. Our Efforts Timeline for CTSA’s and UofL’s CTSI October 12, 2005: Published RFAs (CTSA and Planning Grant) March 27, 2006: Applications Due June 2006: “verbal” good score September, 2006: Fund Grants – UofL Planning Grant January, 2007: Applications Due April, 2007: Associate VP for TranslationalResearch created July, 2007: CTSI October, 2007: Applications Due June 17, 2008: Applications Due June 30, 2008: send for External review October 21, 2008: Applications Due 2009: ? {

6. CTSI Objectives 1) Expand and fully integrate the “academic home” for clinical and translational research that was created with the U of L CTSA Planning grant. 2) Create a multidisciplinary program in research education and career development, utilizing an advanced degree that trains the next generation of clinical and translational investigators. 3) Provide the necessary clinical research resources and translational technologies as well as support in areas such as bioinformatics, biostatistics and ethics to support novel and clinical and translational research. 4) Fully engage the unique and highly diverse population of Kentucky in research and translate our research findings into the community to improve the overall health and well being it’s subjects.

7. CTSI Cores • Education Hornung • Bioinformatics Cooper • Biostatistics, Methodology Rothstein and Ethics • Community Engagement Troutman • Translational Technology Prough and Resources • Clinical Research Resources Sullivan • Regulatory Affairs Foulks • Novel Clinical and Valdes/Eaton Translational Methodologies • Pilot Projects Martinez • Evaluation Barber

8. Executive Committee Craig McClain Carl Hornung Rick Clover Nigel Cooper Adewale Troutman Janice Sullivan

11. Partners (confirmed) Proposed Partners • Nortons • Humana • EPA • Kindred Healthcare • Other KY hospitals – e.g. Baptist UofL Healthcare Jewish Hospital Louisville VAMC Kosair’s Children’s Hospital Trover Clinic and Regional Medical Center Owensboro Medical Health System (OMHS)

12. CTSI Grant Progress • Budget 0% • Intro/Governance 70% • Education 95% • Bioinformatics 90% • Biostatistics, Methodology 100% and Ethics • Community Engagement 100% • Translational Technology 95% and Resources • Clinical Research Resources 50% • Regulatory Affairs 50% • Novel Clinical and 100% Translational Methodologies • Pilot Projects 100% • Evaluation 50%

13. Needs Website Clinical Trials space Long-range space plan Initiate/enhance interactions with partners Institutional resources

14. Planning Grants that yet to be funded • University of Cincinnati Cincinnati, OH • University of Connecticut School of Medicine Farmington, CT • University of Florida Gainesville, FL • University of Hawaii Manoa, HI • University of Illinois Chicago, IL • University of Kansas Medical Center Kansas City, KS • University of Kentucky Lexington, KY • University of Louisville Louisville, KY • University of Maryland School of Medicine Baltimore, MD • University of Missouri Columbia, MO • University of New Mexico Albuquerque, NM • University of North Dakota Grand Forks, ND • University of Oklahoma Health Sciences Center Oklahoma City, OK • University of South Carolina Columbia, SC • University of South Florida Tampa, FL • University of Southern California Los Angeles, CA • University of Tennessee Health Science Center Memphis, TN • University of Virginia Charlottesville, VA • Virginia Commonwealth University Richmond, VA • Wake Forest University Health Sciences Winston-Salem, NC • Wayne State University Detroit, MI • Brown University Providence, RI • Children's Research Institute Washington, DC • Dartmouth College Hanover, NH • Georgetown University Washington, DC • Howard University Washington, DC • LSU Baton Rouge, LA • Medical College of Georgia Augusta, GA • Medical University of South Carolina Charleston, SC • Methodist Hospital Research Institute Houston, TX • Michigan State University East Lansing, MI • Mount Sinai School of Medicine New York, NY • New York University School of Medicine New York, NY • State University New York Stony Brook, NY • Temple University Philadelphia, PA • Texas A&M University College Station, TX • Translational Genomics Research Institute Phoenix, AZ • University of Massachusetts Medical School Worcester, MA • University of Medicine and Dentistry of New Jersey Newark, NJ • University of Arkansas for Medical Sciences Little Rock, AR

15. Institutional Commitment $>.5 million $1 million >$5 million >$5 million $1 million + 1 $22 million UofL CRC support Passport translational research UofL CTSI Education support 12 new biostatistics/informatics faculty lines Eleven endowed chairs ($1 million from the state + $1 million private match) have been dedicated exclusively to the CTSI and translational research, while many others in areas ranging from engineering to business will interact with CTSI.

16. Institutional Commitment $7.5 million $5 million $5 million UofL will receive an appropriation of $7.5 million targeted for translational research. UofL’s request to the General Assembly for a $5 million appropriation to the Dataseam cancer research grid was approved. UofL will raise money for Pilot projects