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NEOPLASIA

NEOPLASIA. Suimin Qiu, MD, PhD, Norbert Herzog, PhD, Valerie Bauer, MD Suimin Qiu, MD, PhD Associate Professor Division of Surgical Pathology The University of Texas Medical Branch. PATH 6266: NEOPLASIA. Neoplasia The new and abnormal development of cells that may be benign or malignant

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NEOPLASIA

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  1. NEOPLASIA Suimin Qiu, MD, PhD, Norbert Herzog, PhD, Valerie Bauer, MD Suimin Qiu, MD, PhD Associate Professor Division of Surgical Pathology The University of Texas Medical Branch

  2. PATH 6266: NEOPLASIA • Neoplasia • The new and abnormal development of cells that may be benign or malignant • Malignant Tumors • Carcinoma • Breast Cancer, colon cancer, prostate cancer • Sarcoma • Liposarcoma • Osteosarcoma • Chondrosarcoma • Leimyosarcoma • Lymphoma • Diffuse large B cell lymphoma • Hodgkin lymphoma • Leukemia • Acute lymphoblastic leukemia • CML t(9;22) • AML-M3 t(15;17)

  3. EMT: Epithelial-Mesenchymal Transition or Transformation E-cadherin Ras PI3K/AKT Snal/Snug TGF- Integrin α1β2 Wnt Hedgehog family

  4. Adenoma to Carcinoma Pathway Normal Adenoma Cancer APC loss K-ras mutation Chrom 18 loss p53 loss Normal Epithelium Hyper- proliferation Early Adenoma Intermediate Adenoma Late Adenoma Cancer

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