1 / 3

IVD Antibodies for sCD40L Marker

Creative Biolabs is a pioneer and leader of the in vitro diagnostics (IVD) antibodies development. Based on years of ample experiences, scientists from Creative Biolabs provide a full range of IVD antibodies custom development service of sCD40L marker for the diagnosis of myocardial infarction (MI) and diabetes.

bellasmith12
Download Presentation

IVD Antibodies for sCD40L Marker

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. IVD Antibodies for sCD40L Marker Creative Biolabs is a pioneer and leader of the in vitro diagnostics (IVD) antibodies development. Based on years of ample experiences, scientists from Creative Biolabsprovide a full range of IVD antibodies custom development service of sCD40L marker for the diagnosis of myocardial infarction (MI) and diabetes. CD40 ligand (CD40L), a member of the tumor necrosis factor family, is involved in the pathogenesis of atherosclerosis through its prothrombotic and inflammatory characteristics. CD40L is generated in hematopoietic cell types, including T lymphocytes, platelets and monocytes, or nonhematopoietic cells, for example, endothelial and smooth muscle cells. CD40L serves essential roles in endothelial cell activation, the secretion of inflammatory cytokines, the modulation of apoptosis and angiogenesis. Recently, the soluble form of the CD40L, soluble CD40L (sCD40L), has got much attention due to its clinical validity as a marker of cardiovascular events. Meanwhile, a growth of sCD40L in the blood was discovered in a number of autoimmune disorders, as well as in chronic inflammatory diseases. Remarkably, sCD40L is connected with unstable plaque and may be a crucial predictor of plaque instability and plaque complication. Figure 1. The left graph shows three functions of sCD40L that secreted from platelets during thrombosis. The right graph shows the shedding of soluble sCD40L during platelet stimulation. (André, P. 2002) sCD40L Marker of Myocardial Infarction MI is able to be identified by clinical features, such as electrocardiographic (ECG) findings, and increased values of biomarkers of myocardial necrosis. It is a main cause of death and disability all over the world. Besides, MI may be the premier performance of coronary artery disease (CAD) or it may occur repeatedly in patients with established disease. A study demonstrated that plasma levels of sCD40L were superior predictors of cardiovascular events, comprising MI and ischemic stroke in patients with AF. Due to the prothrombotic

  2. property of sCD40L, it is more helpful than other biomarkers such as p-selection in predicting cardiovascular events. It has also been indicated that time change of sCD40L over 1 month after MI onset was correlated with G894T eNOS polymorphism and VEGF concentrations. These results suggested that the sCD40L cannot be regarded just as being related to thrombosis and inflammation, but also as playing a relevant role in vascular and endothelial dysfunction. Figure 2. Sketch map of CD40/CD40L and inflammation. When sCD40L engages CD40 on ECs, signaling induces production of ROS, which prevent NO synthesis, and improve endothelial dysfunction. Plaque thrombogenicity is improved by CD40/CD40L–mediated TF expression,, which in turn activates platelets. The activated platelets produce more sCD40L, enhancing the inflammatory reaction. (Szmitko, P. E. 2003) sCD40L Marker of Diabetes Diabetes is a severe complex situation that influences the whole body. The blood glucose or blood sugar levels are too high in patients with diabetes. Diabetes may also lead to heart disease, stroke and even the need to remove a limb. There are several different types of diabetes, among which, type 1, type 2 and gestational diabetes are three major types. Research has proven that raised intracellular levels in and release of sCD40L by platelets of diabetic subjects is a new mechanism which enables to explain stepped-up atherogenesis in diabetes. Meanwhile, the induction of sCD40L expression and secretion from platelets by glucose and AGEs also add evidence to that. Various high-affinity IVD antibody development services for sCD40L marker are available, and our high-quality antibodies will contribute greatly to the success

  3. of your projects. Creative Biolabs also provides other various IVD antibodies. Please feel free to contact us for more information and a detailed quote. Reference 1. André, P. (2002). “Platelet-derived CD40L the switch-hitting player of cardiovascular disease.”Circulation 106(8), 896-899. 2. Szmitko, P. E. (2003). “New markers of inflammation and endothelial cell activation part I.”Circulation 108(16), 1917-1923. Related Services: IVD Antibodies for hsTnI Marker IVD Antibody Development Services for FABP Marker IVD Antibodies for GPBB Marker IVD Antibody Development Services for C-reactive Protein Marker IVD Antibodies for Myeloperoxidase Marker IVD Antibodies for miR-19a Marker IVD Antibodies for miRNA-208b Marker IVD Antibodies for miR-499 Marker IVD Antibodies for miR-328 Marker IVD Antibodies for miR-133 Marker IVD Antibody Development Services for Troponin Marker

More Related