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IVD Antibodies for Sphingomyelin Marker

As an incomparable manufacturer of in vitro diagnostics (IVD) market, Creative Biolabs provides custom development service of high-quality IVD antibodies for sphingomyelin marker. Our IVD antibodies are available for diagnosis of a variety of diseases, such as endometriosis, type 2 diabetes, and obesity.

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IVD Antibodies for Sphingomyelin Marker

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  1. IVD Antibodies for Sphingomyelin Marker As an incomparable manufacturer of in vitro diagnostics (IVD) market, Creative Biolabs provides custom development service of high-quality IVD antibodies for sphingomyelin marker. Our IVD antibodies are available for diagnosis of a variety of diseases, such as endometriosis, type 2 diabetes, and obesity. Sphingomyelin (SM) is a pivotal component of biological membranes, and it is the amplest sphingolipid in mammalian cells. The SM molecule contains two regions: a phosphorylcholine head group attached to a ceramide molecule, and a latter part which consists of a sphingosine backbone and a fatty acid (acyl chain). SM is formed by the transfer of a phosphocholine group from phosphatidylcholine to ceramide, meanwhile, yielding diacylglycerol. This process is catalyzed by SM synthase, and more than two different enzymes with SM synthase activity have been confirmed in mammals. The SM synthase 1 of human was proved to localize firstly to the trans Golgi, however, SM synthase 2 was firstly located in the plasma membrane fraction. Figure 1. Molecular structure of sphingomyelin. Sphingomyelin is a kind of sphingolipid discovered in animal cell membranes, particularly in the membranous myelin sheath that surrounds some nerve cell axons. It is generally composed of phosphocholine and ceramide, and a sphingosine backbone with a fatty acid. (Blake, S. 2010) Sphingomyelin Marker of Endometriosis Endometriosis is a common reproductive disorder, behaved by the presence of endometrial tissue outside the uterine cavity. K. Vouk and his co-workers have demonstrated that sphingomyelins and phosphatidylcholines were potential markers of ovarian endometriosis. Their results showed that endometriosis was connected with improved levels of sphingomyelins and ether-phospholipids,

  2. which might contribute to suppression of apoptosis and influence lipid- associated signaling pathways. In addition, a report has revealed that acid sphingomyelinase (ASM) can be a negative marker for the diagnosis of ovarian cancer because they were lower expressed in ovarian cancer than that in normal cells. Sphingolipids Marker of Metabolic Diseases Metabolic diseases, such as type 2 diabetes and obesity, form a main emerging health crisis. Recently, sphingolipids have displayed to be potential markers of diabetes and the metabolic syndrome. They play vital roles in deciding membrane biophysical properties, topology, and integrity and in many cellular signaling processes, especially apoptosis and proliferation. It has long been identified that sphingolipid levels are unstable in the blood plasma of diabetic patients. Besides, it was revealed that sphingomyelin levels in the plasma membranes of erythrocytes positively related to circulating insulin levels in human patients. In addition, sphingolipid metabolism is extremely connected by a network of enzymes, allowing it available to learn mechanisms of sphingolipid production and signaling with high precision. Figure 2. Sphingolipid metabolism. Ceramide is the centerpiece of the sphingolipid metabolic pathway and can be synthesized de novo from L-serine and palmitoyl-CoA (green), through hydrolysis of sphingomyelin (yellow), or through hydrolysis of glycosphingolipids and sulfatides (purple). Ceramide can also be synthesized from

  3. sphingomyelin through the action of sphingomyelinases, or from ceramide-1-phosphate through the action of ceramide-1-phosphate phosphatase. Finally, ceramide can be further catabolized (blue) to sphingosine and sphingosine-1-phosphate, which are biologically active metabolites and finally to ethanolamine-1-phosphate and C16 fatty aldehydes. (Merscher, S. 2014) IVD antibodies are used widely as diagnostic tools in many different ways. Antibody-based immunoassays are the most generally used diagnostic assays and is the fastest developing technologies for the analysis of biomolecules.Creative Biolabs offers a variety of high-quality IVD antibodies for sphingolipid marker. Some of the most popular sphingolipid marker antibodies are listed in table 1. Table 1. Sphingomyelin marker antibodies. Sphingomyelin Markers Sphingomyelin Markers Antibodies Antibodies Sphingomyelin Synthase 1 Anti-Sphingomyelin Synthase 1 antibody Sphingomyelin Synthase 2 Anti-Sphingomyelin Synthase 2 antibody Delta(4)-Desaturase, Sphingolipid 1 Anti-Delta(4)-Desaturase, Sphingolipid 1 antibody Acid sphingomyelinase Anti-Acid sphingomyelinase antibody Sphingomyelin phosphodiesterase 1 Anti-Sphingomyelin phosphodiesterase 1 antibody Sphingomyelin phosphodiesterase 2 Anti-Sphingomyelin phosphodiesterase 2 antibody Sphingomyelin Phosphodiesterase 3 Anti-Sphingomyelin Phosphodiesterase 3 antibody Sphingomyelin Phosphodiesterase 4 Anti-Sphingomyelin Phosphodiesterase 4 antibody

  4. Various high-affinity IVD antibodies against sphingomyelin marker are available, and our high-quality antibodies will contribute substantially to the success of your projects. Creative Biolabs also provides other various IVD antibodies. Please feel free to contact us for more information and a detailed quote. References 1. Blake, S. (2010). “Unders tanding Dietary Fats and Oils: A Scientific Guide to their Health Effects”. at: http://www.naturalhealthwizards.com/fats-and-oils.html. 2. Merscher, S. (2014). “Podocyte pathology and nephropathy–sphingolipids in glomerular diseases”.Frontiers in endocrinology 5, 127. 3. Vouk, K. (2012). “Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis”.Human Reproduction 10, 2955-2965. available online free Related Services: IVD Antibodies for Acetylcarnitine Marker IVD Antibodies for Apelin Marker IVD Antibody Development Services for ANGPTL2 Marker IVD Antibodies for Cyclophilin A (CyPA) Marker IVD Antibodies for Glycine Marker IVD Antibodies Development Services for GDF-11 Marker IVD Antibodies Development Services for Gal-3 Marker IVD Antibodies Development Services for Irisin Marker IVD Antibodies Development Services for Lysophosphatidic Acid Marker IVD Antibodies Development Services for Prolactin Marker IVD Antibodies Development Services for Urotensin II Marker IVD Antibodies Development Services for VDBP Marker IVD Antibody Development Services for Vitamin D Marker IVD Antibodies Development Services for GCD59 Marker

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