1 / 4

IVD Antibody Development Services for Thyroglobulin Marker

With abundant experience in developing antibodies for analytical research and diagnostic applications, Creative Biolabs is able to provide a full range of thyroglobulin antibody development services for thyroid cancer screening and therapeutic monitoring.

bellasmith12
Download Presentation

IVD Antibody Development Services for Thyroglobulin Marker

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. IVD Antibody Development Services for Thyroglobulin Marker With abundant experience in developing antibodies for analytical research and diagnostic applications, Creative Biolabs is able to provide a full range of thyroglobulin antibody development services for thyroid cancer screening and therapeutic monitoring. We have profound expertise in in vitro diagnostics (IVD) antibody development and are willing to share our expertise with our customers to facilitate their brilliant studies. Introduction of Thyroglobulin Thyroglobulin (Tg), a dimeric protein encoded by the TG gene, is precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). It is synthesized by the follicular cells of the thyroid gland, secreted and stored in the follicular lumen, and finally released into serum along with the thyroid hormones. Human Tg (HTG) is a homodimer of subunits each containing 2768 amino acids. Each Tg molecule contains approximately 100-120 tyrosine residues, but only a small number of these are subject to iodination by thyroperoxidase in the follicular colloid. It is reported that Tg and thyroid are also an important storage of iodine for all body needs, in particular, for many iodine-concentrating organs such as breast, stomach, salivary glands, thymus, choroid plexus and cerebrospinal fluid, etc. In clinic, Tg is considered to be a special marker for integrity of thyroid gland, as well as a tumor marker of thyroid cancer.

  2. Fig.1 Structure of the Thyroglobulin. Thyroglobulin in Differentiated Thyroid Cancer Tg is a large glycoprotein involved in the production of thyroid hormones, which is synthesized in both normal thyroid tissue and thyroid cancer cells. It is released into the blood circulation as a by-product of normal thyroid hormone production and also secondary to any trauma to the thyroid. Differentiated thyroid cancer (DTC) constitutes the most common type of thyroid cancer and is defined by its origin from the thyroid follicular cell, and absence of anaplastic (undifferentiated) histology on a microscopic level. Serum thyroglobulin is not a diagnostic test for thyroid cancer but is recommended to monitor for recurrence or progression of DTC, as it is synthesized and utilized entirely within the thyroid gland. Another substance detected is thyroglobulin antibody (TgAb), which is generated as a result of an associated lymphocytic thyroiditis or an immune reaction to DTC. It is well known that approximately 25–30% of patients with DTC have serum TgAb that can interfere with Tg measurements. The levels of TgAb and Tg in serum change differently in patients with DTC after treatment. It presented that a prominent transient early increase in Tg levels and falling below baseline by 6 months post-Radioiodine ablation in DTC patients with complete resection. This phenomenon may result from Radioiodine-induced thyroid tissue destruction/inflammation with subsequent release of Tg from the

  3. thyroid remnant. TgAb levels decline in the majority of DTC patients treated with total thyroidectomy but not ablated with radioiodine. The levels decrease rapidly after the surgical treatment and continue to decrease over time. The time of disappearance is influenced by the initial TgAb levels and the degree of lymphocytic infiltration. Fig.2. Summary of Tg testing in DTC. (Evans, 2015) Features of IVD Antibody Development Services To aid in the prognosis and diagnosis of sepsis, Creative Biolabs offers an extensive range of IVD antibody development services against thyroglobulin to measure its levels clinically. The features of our services include: Expertise: expert in the development of antibodies for different immunoassays (e.g., ELISAs, immunohistochemistry, Western blot, immunochromatography assay). Experience: years of experience in the IVD field with the completion of numerous IVD-related projects. Efficiency: fast turnaround time and competitive pricing. Facility: fully equipped facility to perform antigen & antibody conjugation, protein characterization and purification.

  4. Creative Biolabs specializes in custom antibody and assay development for the diagnosis of a variety of diseases and infections. We have experts who are able to develop high-affinity IVD antibodies against varies of markers. If you are interested in our IVD antibodies discovery services, please contact us for more details. Reference 1. Evans M, et al.(2015). “Thyroglobulin in differentiated thyroid cancer.”Clinica Chimica Acta. 444(15): 310-317.

More Related