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Disperse and colloidal systems

Disperse and colloidal systems. Types of disperse systems. The term "Disperse System" refers to a system in which one substance ( t he d ispersed p hase ) is distributed, in discrete units, throughout a second substance ( the continuous p hase or vehicle).

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Disperse and colloidal systems

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  1. Disperse and colloidal systems

  2. Types of disperse systems • The term "Disperse System" refers to a system in which one substance (the dispersed phase) is distributed, in discrete units, throughout a second substance (the continuous phase or vehicle). • Each phase can exist in solid, liquid, or gaseous state .

  3. dispersion Types of disperse systems coarse dispersion > 500 nm Colloid dispersion 1 – 500 nm True solution < 1 nm homogenous systems, salt, acid and base solutions microheterogenous system (plasma, macromolecular solutions) heterogenous systems coagulation (floculation) condensation,aggregation

  4. Properties of disperse systems

  5. Properties of disperse systems

  6. koloid • Partikelukuran 1- 500 nm • Opalescent • Efekthyndal • Mengalamigerak brown (adahubunganantaraukuranpartikel, viskositasdenganvelocity)

  7. Bandingkanlarutandankoloid

  8. Gerak brown

  9. Tidakdapatmelaluimembransemipermeabel • Hanyadapatdilihatdenganmikroskopelektron • Stabil (dapatdiendapkandenganultrasentrifugasi) (adahubunganantaraukuranpartikledengankecepatansedimentasi= hukum stokes)

  10. Mikroskop optical danmikroskopelektron

  11. Hukum Stokes • V = d2g(ρ1- ρ 2) 18η

  12. d = diameter partikel g =gravitasi η=viskositasmedium ρ1= Kerapatan medium ρ2 =Kerapatanpartikel

  13. Pengaruhukpartikelthdkec. sedimentasi

  14. Bagaimanapengaruhukuranpartikelterhadapsifatnya (keuntungan) - Dissolution rate - Uniform distribution - Penetrability (difusifitas) - Lack of grittiness - as drug delivery system

  15. Faktor yang mempengaruhistabilitaskoloid • Ukuranpartikel • Bentukpartikel • Muatanpartikel (zeta potensial) • Kondisi medium dispers (pH, jenis solvent, jenisbahantambahan lain dalamsolven)

  16. Bentukpartikel

  17. Pengaruhbentukpartikelpadasedimentasi

  18. Zeta potensial

  19. Macam-macamdispersikoloid • 1. liofilik (tdkcptmengendap) • Hidrofilik (akasia/gelatin dalam air) • Lipofilik 2. Liofobik (partikelanorganik (silver, gold) dalam air 3. Ampifilik

  20. Contohkoloidampifilik(pembentukanmisel)

  21. Pembuatankoloid

  22. Metodepembuatandengandispersi Solvent evaporation methode polimerdilarutkandalampelarutorganiksepertidiklorometana, kloroformatauetilasetat, yang jugadigunakansebagaipelarutuntukmelarutkanobat-obathidrofobik. diemulsikandalamlarutanberair yang mengandungsurfaktanatauemulsifying agent. pelarutorganikdiuapkanmasing-masingdenganpengurangantekananataudenganpengadukanterus-menerus. Ukuranpartikel yang terbentukdipengaruhiolehtipedankonsentrasistabilizer, kecepatan homogenizer dankonsentrasipolimer

  23. Metodepembuatandengankondensasi Ionic gelationmethode (coaservationmethode) mencampurduafaseberair, salahsatufasenyaadalahpolimerdanfase yang lainnyaadalahpolianiontripolifosfat (TPP). Padametodeini, muatanpositif yang dimilikiolehgugus amino darikitosanberinteraksidenganmuatannegatifdari TPPuntukmembentukkoaservasidenganukuran nanometer.

  24. Contohpolimer (kitosan)

  25. Contohcrosslingker (Na Tripoliphosphat)

  26. Aplikasi (koloidsebagaipembawaobat) • Pemilihanbahanpembawa (polimer) berdasarkanbeberapafaktoryaitu • 1) ukuranpartikel yang diinginkan; • 2) sifatobatitusendiri, sepertikelarutannyadalam air, danstabilitasnya; • 3) karakteristikpermukaanpartikelsepertimuatanpartikeldanpermeabilitasnya;

  27. 4) derajatbiodegradasinya, biokompatibilitasnya, dantoksisitasnya; • 5) profilpelepasanobat yang diinginkan.

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