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Effect of air pollution exposure during pregnancy on the steroid profile of newborns

This study examines the association between air pollution exposure during pregnancy and alterations in the steroid profiles of newborns. The findings suggest that PM10 exposure is associated with an overall increase in stress steroid production, while NO2 exposure is associated with increased 6bOH-cortisol production. The study highlights the importance of considering maternal mobility in air pollution modelling.

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Effect of air pollution exposure during pregnancy on the steroid profile of newborns

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  2. Effect of air pollution exposure during pregnancy on the steroid profile of newborns Rüedi S*, Proietti Elena*, Gorlanova O, Dick B, Flück C, Röösli M, Latzin P, M. Frey B, Frey U

  3. Introduction • Prenatal air pollution exposure has adverse effects on the infant’s respiratory system. • One pathway involved might be via oxidative stress, possibly leading to a modified pattern of steroid production.

  4. Aim We examined a possible association of air pollution exposure during pregnancy and steroid metabolites in the newborn’s urine.

  5. Methods – BILD cohort Prenatal recruitment Age 1 month Urin collection

  6. Methods – exposureandoutcome • PM10 from background monitoring station • NO2 • background monitoring station and • hybrid time-space regression model • Spot urine • mass spectrometry/ gas chromatography

  7. Methods - statistic season Adjusted for: distance to road urban area smoking exposure socio-economic status Sex, gestational age, weight delivery mode

  8. Methods - steroids 11- β HSD2 (NAD+) 11- β HSD1 (NADH) 5β-reductase CYP3A 5β-reductase 5β-DHF DHE 5α-DHF 6β-OHF 3αHSD 3αHSD Cortisone E Cortisol F α-THF THF THE 20aHSD/20βHSD α-cortolone α-cortol β-cortolone β-cortol

  9. Results – PM10(aRR per 10mg/m3 PM10 increase) N=129 All 1.46 (1.06/2.02) Cortisol/Cortisone 1.04 (0.81/1.34) Branche F 1.42 (0.96/2.1) Branche E 1.45 (1.06/1.99) All metabolites 1.6 (1.14/2.28) Branche F metabolites 1.62 (1.04/2.54) Branche E metabolites 1.60 (1.14/2.23)

  10. Results – NO2background(aRR per 10mg/m3 NO2 increase) N=120 All Noassociation Cortisol/Cortisone Noassociation 4.10 (1.6/10.6) Branche F Noassociation Branche E Noassociation *distance to road (50m) aRR 0.98 (0.97/0.99) 6βOH cortisol 4.9 (1.6/14.9)* All metabolites Noassociation *Pathologic CTG aRR 1.6 (1/2.5)

  11. Results – NO2model(aRR per 10mg/m3 NO2 increase) N=120 All Noassociation Cortisol/Cortisone Noassociation 6βOH cortisol/F 1.14 (0.9/1.5) Branche F Noassociation Branche E Noassociation 6βOH cortisol 1.3 (0.9/1.7) All metabolites Noassociation

  12. Conclusions Air pollution exposure during pregnancy is associated with alterations of the steroid profiles in newborns’ urine. PM10 exposure during pregnancy is associated with an overall increase of stress steroids production.

  13. Conclusions background NO2 is associated with increased 6bOH-cortisol 6bOH-F/F ratio, which may suggest induction of the cytochrome enzymes. If air pollution modelling was purely based on home location of mothers without considering maternal mobility, the risk ratio significantly decreased Even at low environmental doses of air pollution we found steroids response as know trigger such as perinatal stress

  14. Thankyou Elena.proietti@ukbb.ch

  15. Methods - DAG Smoking Maternal education SES Pregnancy behaviour psychological stress sectio Gestational age + weight Urban/rural home Season sex Air pollution Steroids

  16. PM10 effect on overall steroids production – different adjustments

  17. Air Pollution exposure of the BILD cohort (region of Bern – Switzerland)

  18. European Environment Agency – NO2 annualaverages 2005

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