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Purinsynthese

Purinsynthese. + NH 3. O. C. O. O. O. O. O. + NH 3. P. P. C. - OOC. CH 2. CH 2. COO -. P. P. H 2 N. C. C. CH 2. CH 2. COO -. H. O. O. O. H. O. HO. OH. O. C. O. O. O. O. O. P. P. O. O. O. O. HO. OH. Glutamin. Glutamat. NH 2. 5-Phosphoribosyl-1-amin.

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Purinsynthese

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  1. Purinsynthese

  2. +NH3 O C O O O O O +NH3 P P C -OOC CH2 CH2 COO- P P H2N C C CH2 CH2 COO- H O O O H O HO OH O C O O O O O P P O O O O HO OH Glutamin Glutamat NH2 5-Phosphoribosyl-1-amin 5-Phosphoribosyl-1-pyrophosphat (PRPP) W. Storch D. Doenecke

  3. ATP +NH3 +NH3 P C -OOC CH2 CH2 COO- H2N C C CH2 CH2 COO- H H O O O C C H H THF H O C O +NH3 H C COO- O O HO OH CH2 P C O OH O Glycin Glutamin Glutamat +NH3 NH THF H NH2 CH2 N C N O H Phosphoribosylamin ADP

  4. ATP ATP ATP P O HO O THF O C C C H CH2 H O + O C C H3N H O O O C N N N N HC HC HC HC HO HO C N HC N N HC HC H NH C C O O O O O O O O O O O HO OH O N N N N C C C C O H N N N CH C CH CH2 CH N C C C CH2 CH P P P C C C C C C O O O OH OH OH O C C C C C C C HN NH2 NH2 H H O NH NH2 N N NH2 O HN NH2 NH2 H N HO C C H C C C H O O O O O O Bicarbonat Fumarat Aspartat THF H2O ADP ADP Inosinat (IMP) ADP

  5. GTP P O HO C O CH2 HO + O C C C H3N H O O N N HC HC CH2 HO C C O C HN H HO OH O N N O O C C O CH P C C C C C O O C H O NH N N N O C C C H H O O NH2 Aspartat Fumarat H GDP Inosinat (IMP) Adenylat (AMP)

  6. ATP H2O +NH3 +NH3 P C -OOC CH2 CH2 COO- H2N C C CH2 CH2 COO- H H O NADH+H+ O NAD C O N N N HC HC HC HO OH N N N C C C O O O C C C C C C N NH NH HN HN N C C C H O Glutamin Glutamat H AMP NH2 Inosinat (IMP) Guanylat (GMP)

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