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Women’s Health And The Women’s Health Initiative Study

Women’s Health And The Women’s Health Initiative Study. Lisa Killinger, DC. The Women's Health Initiative (WHI) is a major 15-year research program to address the most common causes of death, disability and poor quality of life in postmenopausal women --. Primary topics studied:.

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Women’s Health And The Women’s Health Initiative Study

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  1. Women’s Health And The Women’s Health Initiative Study Lisa Killinger, DC

  2. The Women's Health Initiative (WHI) is a major 15-year research program to address the most common causes of death, disability and poor quality of life in postmenopausal women --

  3. Primary topics studied: • cardiovascular disease • cancer • osteoporosis

  4. More on the WHI • Launched in 1991 • A set of clinical trials • One observational study • Involve more than 161,000 women • Mostly healthy & postmenopausal

  5. Randomized Clinical Trial (RCT) • Hormone Replacement Therapy Trial (HRT) • Dietary Modification Trial (DM) • Calcium/Vitamin D Supplementation Trial (CaD)

  6. Observational Study (OS) • OS Participants: • From 40 Clinical Centers (CC) nationwide • 167,000 women aged 50-79; 67,000 in RCT 100,000 in OS • 20% overall minority recruitment:10 CC's with goal of 60%

  7. Community Prevention Study (CPS) • CPS Participants: • at CDC funded University-based Prevention Research Centers

  8. CPS Study Topics • Reducing CVD Risk Among Black Women (Johns Hopkins) • CVD Peer Support in Afr-American Women (U Alabama) • Environmental Factors & Physical Activity in Women (SLU) • Osteoporosis Prevention (UNC; Chapel Hill) • Diabetes Care in Minority Women (UNC)

  9. WHI- HRT studyThe “pill” and its effect on women • Heart Disease • Breast Cancer • Osteoporosis • Stroke • Dementia

  10. Estrogen + Progestin vs. Placebo The rate per 10,000 women per year

  11. Summary of Results: Heart • Women on Estrogen/Progest Pill not protected from heart disease • E & P: 24% Increase in heart disease risk • Highest risk increase in women w/ hi LDL Manson, et al. NEJM Aug 7, 2003. Vol. 349(6):523-534.

  12. Summary of Results: Breast Cancer • E & P Group: 24% increase in Breast Cancer risk Chebowski, et al. JAMA 2002 June 225. Vol. 289(24): 3243-3254.

  13. Results: Dementia • May, 20, 2003 JAMA • E&P Group: Twice the risk of dementia (Alzheimer’s) • Resource Orgs: • www.alzheimers.org • ADEAR: 1-800-438-4380

  14. Other Results… • E&P and Stroke: Risk increased 31% • E &P and Blood Clots: Risk increased 61% • Osteoporosis and Colorectal Cancer: E&P may protect, but risks outweigh the benefits • E&P part of study was cancelled due to increased rates of disease!

  15. Resources on Women’s Health • www.4women.org • Nat’l Women’s Health Info Center • 1-800-994-Woman • www.nhlbi.nih.gov/whi (women’s health init) • National Domestic Abuse Hotline: 1-800-799-SAFE (violence is a leading cause of injury in women ages 15-54)

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