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Maternal Inheritance

Maternal Inheritance. Thanks Mom!. Mitochondria. Inheriting mitochondria. Only from the mother. Mitochondrial DNA. No chromosomes No histones Circular DNA No repair enzymes Mutates more frequently. Mitochondrial diseases. Defects in energy metabolism

bertha-hardy
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Maternal Inheritance

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  1. Maternal Inheritance Thanks Mom!

  2. Mitochondria

  3. Inheriting mitochondria • Only from the mother

  4. Mitochondrial DNA • No chromosomes • No histones • Circular DNA • No repair enzymes • Mutates more frequently

  5. Mitochondrial diseases • Defects in energy metabolism • Lebers hereditary optic neuropathy (LHON) • Mitochondrial myopathy encephalopathy lactin acidosis syndrome (MELAS) • Ooplasmic transfer • Healthy mitochondria added to an infertile woman’s oocyte (30 children born)

  6. Heteroplasmy • Possibility that mutations exist in some mitochondria and not others within the same cell. • Gametes may or may not have mutated mitochondria, harder to track the trait within families • Variable expressivity

  7. Tracking maternal DNA

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