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POWERWULF CLUSTERS

POWERWULF CLUSTERS. World’s Leading Provider of Turn-key Compute Solutions for NGS / Bioinformatics. ABOUT US. Founded in 1989 Over 1000 PowerWulf Clusters Delivered World Wide 350+ PowerWulf Clusters Dedicated Compute Appliances for NGS / Bioinformatics Mission Statement

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POWERWULF CLUSTERS

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  1. POWERWULF CLUSTERS World’s Leading Provider of Turn-key Compute Solutions for NGS / Bioinformatics

  2. ABOUT US • Founded in 1989 • Over 1000 PowerWulf Clusters Delivered World Wide • 350+ PowerWulf Clusters Dedicated Compute Appliances for NGS / Bioinformatics • Mission Statement • Tier 1 Manufacturing & Support at Commodity Price • Custom Configured Products Include • Turn key PowerWulf Compute Clusters • RaidStation Storage Solutions • High Performance Workstations & Servers

  3. Life Science SUCCESS • Selected by Roche / 454 and CLCbio as OEM Hardware Provider • Over 60% of ALL WORLDWIDE data off GS FLX Titanium Platform is analyzed on PSSC Labs Platform • Roche’s Success in this space linked directly to PSSC Labs PowerWulf Cluster solution • CLCbio is a leader in genomics software solutions • Certified our PowerWulf Clusters and Servers Compatible with Life Technologies’ Bioscope & Illumina’sCasava Applications • Pacific Biosciences considering PSSC Labs as OEM Hardware Provider • Recent LARGE Cluster Wins • Western Kentucky University – 5000+ Cores • PSSC Labs Selected after evaluation of Dell, HP, IBM • OpenX.org – 7000+ Cores • PSSC Labs Selected after evaluation of Dell, HP, IBM • MIT / Harvard / HHMI Neuroimaging Center • Largest GPU Cluster at MIT • Revolutionary POWERSERVE DUO TI2000 • Perfect Cluster Building Block • Tool-Free Design • Power Saving Eco Friendly Features • World Wide Support & Maintenance

  4. NGS/Bioinformatics Experience • Partnerships w/ leading Sequencing Platform Providers • Roche / 454 • OEM Provider of GS FLX Titanium Cluster (www.pssclabs.com/roche) • Life Technologies • Certified Cluster Solutions w/ Bioscope Preconfigured • Illumina • Certified Cluster / Server Solutions w/ Casava Preconfigured • Pacific Biosciences • Potential OEM Proider of off line cluster for new RS platform • Ion Torrent • Certified Workstation w/ Ion Torrent Software • CLC Bio • Selected as OEM Hardware Provider of Genomics Machine / Factory

  5. Why Our Success in NGS • Delivery Fully Functional / Turn Key Systems • Biologist are typically not system administrators. Just need a system that works out of the box. • Superior Knowledge & Support • You will have direct communication with the PSSC Labs Cluster Engineer that built, tested and configured the system with your applications. • Our Remote Assist support provides greater more responsive support than any other vendor • We Understand Your Business • Seqwright needs a knowledgeable cost effective hardware provider that ensures they deliver their customer results on time, every time. • Our systems are considered the industry’s most reliable with a failure rate >0.01%. This is a direct result of our superior testing procedure

  6. PERFormance • PSSC Labs Runs Benchmarks Provided by Application to Certify Systems • Typical benchmarks include small and large data sets for all pipeline steps (mapping, assembly, alignment) • Example • WT Run is one of three stress tests we run to certify our clusters for Bioscope • Results: DURATION= 6 hours 36 minutes 44 secs • Configuration: 8 Core (2.67 Ghz) / 48GB Memory)

  7. Performance • Information obtained from end users • Illumina / Casava • UCI Irvine • We are sequencing Drosophila (fruity fly) samples. The genome is approximately 1.2 x 108 base pairs. • One lane of paired-end, 75bp data from an Illumina GA2 machine gives about 25X coverage of a genome. • Roughly 35 million pairs of reads per lane or 2* 75 *35e6 = 5.25e10 base pairs of data. • We sequence 3 lanes per sample. Pipeline involves a lot of custom software to do our analyses, and we can entirely process a single sample in about 12 hours. This is much more than simply doing the alignments • System Configuration • PowerServe Duo T2400 (Single SMP System) • 8 Processor Cores / 2.4 Ghz • 128 GB System Memory • 40 TB USABLE High Speed Storage Space

  8. Performance • Information obtained from end users • Illumina / Casava • St. Radbound University • “Mapping one exome sample to the human reference takes about 8.5 hours using Bioscope 1.3” • System Configuration • PowerWulf Cluster • 64 Processor Cores / 2.53 Ghz / 8 Cores Per Node • 4 GB Memory Per Core

  9. Performance • CLC Bio Genomics Factory Comparison • PSSC Labs is OEM Provider of Genomics Factory • 156 Cores (12 cores per node / 2.53 Ghz) • 4 GB of Memory Per Core • Stated Performance on Website • Mapping, whole human genome, 15x coverage: 32 Full Human Genomes Per Week (2 x 100 basepairIllumina GA – data • Whole human transcirptome analysis (RNA-seq): 600 Samples per week (130 million 50bp SOLiD reads

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