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PPAR Signaling Pathway

PPAR Signaling Pathway. SIGMA-ALDRICH. PPAR Signaling Pathway

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PPAR Signaling Pathway

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  1. PPAR Signaling Pathway SIGMA-ALDRICH

  2. PPAR Signaling Pathway Similar to other nuclear hormone receptors, peroxisome proliferator-activated receptors (PPARs) act as ligand-activated transcription factors. When bound to its fatty acid ligand, PPAR forms a heterodimeric complex with the retinoid X receptor (RXR) to regulate transcription. PPAR is activated by prostaglandins and leukotrienes and regulates the gene expression of proteins involved in the storage of fatty acids. PAR is weakly activated by fatty acids, prostaglandins, and leukotrienes. Its physiological ligand has not been identified. References Fajas, L., et al., Peroxisome proliferator-activated receptor-  : from adipogenesis to carcinogenesis. J. Mol. Endocrinol., 27, 1-9 (2001). Qi, C., et al., Peroxisome proliferator-activated receptors, coactivators, and downstream targets. Cell. Biochem. Biophys., 32, 187-204 (2000).

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