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Ch. 23 Controlling Chromatin Structure. Chromatin remodeling and activationRemodeling complexesTxn factorsHistone ModificationsDNA methylationActive and inactive chromatin. Control of gene expression. Activation of chromatin structureInitiation of txnTxn processingTransport to cytoplasm
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1. Biol 568Advanced Topics in Molecular Genetics
2. Ch. 23 Controlling Chromatin Structure
3.
Chromatin remodeling and activation
Remodeling complexes
Txn factors
Histone Modifications
DNA methylation
Active and inactive chromatin
4. Control of gene expression Activation of chromatin structure
Initiation of txn
Txn processing
Transport to cytoplasm
Translation
5. Gene expression analyses Three test systems:
Oocyte system
Transfection systems
Transgenic systems
6. Chromatin can have alternative states Local chromatin
Important part for gene expression:
The gene is in an active state only in the cells in which is expressed
Epigenetic patterns of gene expression
Heterochromatin formation
7. Activation of Txn In prokaryotes:
Requires activator/ repressor
Increase of activator/repressor concentration affects txn
Equilibrium model
8. Equilibrium model Fig. 23.1