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Olfactory, Gustatory

Olfactory, Gustatory. Objectives: For each sense identify… specialized organs, anatomy receptor structure and specializations receptor signal transduction mechanism coding of intensity and duration pathway of conduction to the CNS. Olfaction . Sense organs: nose & olfactory epithelium

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Olfactory, Gustatory

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  1. Olfactory, Gustatory Objectives: For each sense identify… • specialized organs, anatomy • receptor structure and specializations • receptor signal transduction mechanism • coding of intensity and duration • pathway of conduction to the CNS

  2. Olfaction Sense organs: nose & olfactory epithelium Receptor type: neuron w/ memb. G-proteins Receptor signal transduction mechanism Coding of intensity and duration Pathway of conduction to the CNS Coding for perceived sensation - receptors are specific for only a few ‘smells’

  3. Olfaction Sense organs: nose & olfactory epithelium Olfactory area in humans is about 2.5 cm2 w/ approx. 5 million sensory receptor cells. Recognize thousands of odors.

  4. Neuronal receptor synapses with CN I - goes to olfactory cortex in medial temporal lobe

  5. Receptor : neuron w/ membrane G-proteins Olfactory receptors are specific to a few molecules G-proteins - bind one or a class of molecules cAMP is second messenger in some receptors …….leading to Na+ channel opening

  6. IMDJSLDFYFMDLDSUDKDKFIGOTPRSTUTDI receptors odorants “citrus” “wet grass” “moldy” • The receptors are located randomly in the epithelium, each neuron has its own type of receptor But their axons cluster by receptor type (thus, by odor) in the olfactory bulb

  7. Gustation - the sense of taste Sense organs: tongue & throat, taste buds Receptor type: non-neuronal

  8. Transduction: Each taste has a specific mechanism to depolarize cell, ICF Ca2+, release NT Salty – Na+ influx Sour – H+, block K+ Bitter – G-protein:IP3 Sweet – G-protein: cAMP, block K+

  9. Taste path: • CN VII (facial) • CN IX (glph.) • CN X (vagus) •  medulla • thalamus • gustatory cortex

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