GERD Drugs and Devices Market Analysis 2017-2023

1. GLOBAL GERD DRUGS AND DEVICES MARKET-ANALYSIS AND FOREST, 2017-2023 (Focus on Devices, Drugs, Market share Analysis, Patent Landscape and Country Analysis) 1 The Research Scope and Methodology 1.1 Scope of the Report The report constitutes of an in-depth study of the global Gastro Esophageal Reflux Disease (GERD) Drug and Devices market, including a thorough analysis of the product across different regions. The study also presents a detailed analysis of the market dynamics and the estimation for market size over the forecast period, 2017 to 2023. The purpose of the study is to gain a holistic view of the global GERD Drug and Devices market in terms of various factors influencing it like recent trends, technological advancements, and regulatory aspects of the market. In addition, the study also comprises of exhaustive information on the product shortcomings, unmet needs, competitive landscape, restraints and opportunities and the other vital information with respect to GERD products. The scope of this report is centred upon conducting a detailed study of the solutions allied with the market. The market has been segmented into ‘Product’ both Drugs & Devices, ‘Route of Administration’, ‘Dosage form’ and ‘Region’. Moreover, the global GERD Drug and Devices market report deliberates in detail, the analysis of all the macro & micro factors. It also evaluate the opportunities in the market for stakeholders and provide details of a competitive landscape for market leaders. • Key learnings of this research study are as following: - To understand the competitive landscape in the GERD Drug and Devices market in terms of leading players To identify the geographical setting holding the largest market share in the market To gauge the preferred route of procurement of GERD Drug and Devices • • 1 www.bisresearch.com  sales@bisresearch.com

2. • To gain insights in terms of current reimbursement policies, regulations, directives, laws and standards etc. in this space To understand the market dynamics (Drivers, Challenges and Opportunities) for different geographical location To estimate the market share, growth and value of the GERD Drug and Devices market during the forecast period Report coverage of the global GERD Drug and Devices market includes key elements considered for the detailed analysis of the market: Market Overview provides an in depth analysis of the global GERD Drug and Devices market scenario, economic outlook, technology trends, and legal trends Market Dynamics: Drivers, Challenges and Opportunities related to the global GERD Drug and Devices market Competitive Insights provides a comprehensive understanding of the business environment of the market, growth matrix, market share analysis, and CCI index among others An in-depth analysis of the different product divisions across various regions consists of valuable insights into the trend followed in the market • • • • • • Figure 1 Key Elements Considered In-Depth Market Dynamics Analysis Exhaustive Product Segmentation Comprehensive Competitive Insights Detailed Market Share Analysis Extensive Coverage of Market Players Thorough Analysis of Business Opportunities BIS Research Analysis 2 www.bisresearch.com  sales@bisresearch.com

3. The global GERD Drug and Devices market is further segmented as below: Figure 2 Global GERD Drug and Devices Market Segmentation Route of Administration (Qualitative) Dosage form (Qualitative) By Geographical Regions By Product type • Drug class • Antacids • Proton Pump Inhibitors • H2 Receptor Antagonists • Devices • Invasive • Non-Invasive • Oral • Parenteral • Solid • Liquid • North America • Europe • Asia Pacific (APAC) • Rest of the World (RoW) BIS Research Analysis 1.2 BIS Research Market Research Methodology The research methodology design adopted for this specific study includes a mix of data collected from primary and secondary sources. Both primary sources (in-house experts, industry leaders and market players) and secondary sources (a host of paid and unpaid databases) along with analytical tools have been used exhaustively to build the forecast and predictive models. 3 www.bisresearch.com  sales@bisresearch.com

4. Figure 3 BIS Research Market Research Methodology RESEARCH APPROACH PRIMARY RESEARCH SECONDARY RESEARCH 1. DATABASE FOR KEY INDUSTRY PARTICIPANTS (DKIP) PREPARATION STUDYING THE MARKET STRUCTURE The primary sources from the supply side include industry experts such as CEOs, vice presidents, marketing directors, technology and innovation directors, and related key executives from various vendors providing technology solutions, associated service providers, and system integrators operatingin the targetedregions. E.g. CIO’s, VP, DirectorNew ProductDevelopment,Director–operations Mainly used to obtain key information about the industry’s value chain, the total pool of key players IDENTIFY MARKET, TECHNOLOGY AND COMPETITOR TRENDS 2. DISCUSSION GUIDE PREPARATION Understand market classification, and segmentation according to industry trends to the bottom-most level, regional markets, and key developments from both market- and technology-oriented perspectives A detailed questionnaire is shared with the primary respondent covering all the aspects related to the report topic 3. SCHEDULING AN APPOINTMENT Appointments are scheduled with CIO’s, VP – healthcare companies, Director with prior appointmentsand the discussionguide is shared with the primary respondentprior to the call INTEGRATE INFORMATION Integrate information within relevant documents to form launch pad for primary research 4. CALL EXECUTION A roundtable discussion is held with the KIP with the aim to gather first hand information about the technology,recent developmentsin the technologyand future outlook/ growthor decline VENDORS CONSULTANT RESELLERS 5. DOCUMENTATION POTENTIAL RESPONDENTS The interview is recorded and the information gathered in put on the drawing board with the informationcollectedthroughsecondary research. END USER MSP’s BIS Research Analysis Primary Data Sources The key data points taken from Primary Sources includes: • Validation and Triangulation of all the numbers and graphs • Validation of report segmentation and key qualitative findings • Understanding the competitive landscape • Understanding and considering the market dynamics factors for various market segment and sub-segment • Validation of impact analysis of macro and micro factors in different countries • Percentage split of individual markets for geographical analysis Secondary Data Sources The research study involves the usage of extensive secondary sources such as databases, company websites, and annual reports, among others. 4 www.bisresearch.com  sales@bisresearch.com

5. The following figure exhibits key secondary data sources considered in this report: Figure 4 Secondary Data Sources STOCK ANALYST WEBSITES COMPANY SOURCES Seeking Alpha Yahoo Finance Wiki finance The Wall Street Journal Annual Reports Press Releases SEC Filings Investor Presentations Financial Disclosures SECONDARY DATA SOURCES GOVERNMENT AND REGULATORY SOURCES PUBLIC AND PRIVATE DATABASES Medline PubMed National Library of Medicine ProQuest Thin Database CMS Datasets Medicare Beneficiaries Database Oxon Epidemiology The Centre for Disease Control (CDC) The World Health Organization (WHO) The National Health Services (NHS) The National Center for Biotechnology Information (NCBI) The Food & Drug Administration of United States (U.S. FDA) BIS Research Analysis The key data points taken from secondary sources include: • Segmentation breakups, split-ups, and percentage shares • Data for market value • Key industry trends of the top players of the market • Qualitative insights into various aspects of the market, key trends, and emerging areas of innovation • Quantitative data for mathematical and statistical calculations The following figure exhibits the methodology adopted for estimating the global GERD Drug and Devices market: 5 www.bisresearch.com  sales@bisresearch.com

6. Figure 5 Top Down and Bottom Up Approach Total global GERD Drug and Devices market size ($million) Market value of global GERD Drug and Devices market Percent split for the product type and sub-types of global GERD Drug and Devices market Summation of x & y Geographical split Average selling price (ASP) for each type of product (Y) Regional and country-wise market for each sub- segment Products into number of units (X) Analysis of macro & micro factors BIS Research Analysis Note: The above approach has been followed for the market estimation of all the product segments related to GERD Drug and Devices market Having estimated the global market size, the forecast employs a set of macro factors such as the population, disease prevalence rate, population, healthcare expenditure, disposable income, and Gross Domestic Product (GDP), among others. Assumptions and Limitations The following figure exhibits the standard assumptions and limitations which have been followed throughout the research study of the global GERD Drug and Devices market: 6 www.bisresearch.com  sales@bisresearch.com

7. Figure 6 Assumptions and Limitations CURRENCY CONVERSION LIMITATIONS • The base currency considered for this study is U.S. $ • In the Company Profiles section, for the companies having revenues in any other currencies, is converted in to U.S. $ • The currencies other than U.S. $ are converted to U.S. $ for all statistical calculations considering the average conversion rate for the particular year • The currency conversion rate is taken from historical exchange rate of Oanda website • Technologies currently used are expected to persist through the forecast with no major breakthrough in technology • The economic downturn in future was not taken under consideration for market estimation and forecast AVERAGE SELLING PRICE (ASP) ASSUMPTION FOR MARKET ESTIMATION • The ASP is calculated for the year 2015 & 2016 and the currency considered is U.S. $ • For calculating the ASP of the market products, the weighted average of the list price of products has been considered • The base year considered for the calculation of market size was 2015. Instances where the market size for the FY 2015 were not available from primary or secondary sources, at such instances the values were estimated based on the Delphi method. • The historical year analysis was done from the FY 2010 to FY 2014 and the market size was estimated for the FY 2016 and projected from the year 2016 to 2023 BIS Research Analysis 7 www.bisresearch.com  sales@bisresearch.com

8. TABLE OF CONTENTS 1 Report Scope and Methodology 1.1 Scope of the Report Executive Summary 1.2 Global GERD Therapy Market Segmentation 1.3 Key Objectives 1.4 Research Methodology 1.4.1 Data Triangulation 1.4.2 Secondary Sources 1.4.3 Primary Sources 1.4.4 Top-Down Approach 1.4.5 Bottom-Up Approach 1.4.6 Assumptions and Limitations 2 Market Overview 2.1 1.4.7 Data and Prediction Modelling Introduction 2.2 Phenotypic classification of GERD 2.3 GERD Prevalence 3 Market Dynamics 3.1 2.4 Treatment options Market Drivers 3.2 Market Challenges 4 Drug Pipeline Analysis 5 Competitive Landscape 5.1 Key Developments & Strategies 3.3 Market Opportunities 5.2 Market Share Analysis 5.2.1 PPIs Drugs 5.2.2 H2 Receptor Antagonists 5.2.3 Other Drugs 6 Industry Insights 6.1 5.2.4 Device Manufacturers Regulatory Bodies and Associations 7 Global GERD Drug Market by Route of Administration, 2016-2023 (Qualitative) 7.1 Overview 6.2 Patent Landscape 7.2 Oral 8 Global GERD Drug Market by Dosage Form, 2016-2023 (Qualitative) 8.1 Overview 7.3 Parenteral 8.2 Solid 8.3 Liquid 8 www.bisresearch.com  sales@bisresearch.com

9. 9 Global GERD Market by Drugs, 2016-2023 9.1 Overview 9.2 GERD Drug Market by Geography 9.3 GERD Drug Market by Type 9.3.1 H2 Receptor Antagonist 9.3.2 Proton Pump Inhibitor (PPi) 9.3.3 Antacids 10 Global GERD Market by Devices, 2016-2023 10.1 Overview 9.4 Patent Expiry & Generic Launch of Major Brands 10.2 GERD Device Market by Geography 10.3 GERD Device Market by Type 10.3.1 MUSE –Medigus Ultrasonic Surgical Endostapler 10.3.2 LINX Management System 10.3.3 Stretta Therapy 10.3.4 Bravo Reflux Testing System 10.3.5 Digitrapper reflux testing system 10.3.6 Others 10.3.6.1 Endostim Neurostimulation System 10.3.6.2 EsophyX 10.3.6.3 GERDX 11 Global GERD Drug and Devices Market by Region, 2016-2023 11.1 Overview 10.3.6.4 Durasphere GR 11.2 North America 11.2.1 North America GERD Drug Market by Country 11.2.1.1 U.S. 11.2.1.2 Canada 11.3 Europe 11.3.1 Europe GERD Drug Market by Country 11.3.1.1 Germany 11.3.1.2 France 11.3.1.3 U.K. 11.3.1.4 Italy 11.3.1.5 Norway 11.3.1.6 Sweden 11.3.1.7 Switzerland 11.3.1.8 Finland 11.3.1.9 Rest of Europe 11.4 Asia Pacific (APAC) 11.4.1 APAC GERD Drug Market by Country 11.4.1.1 China 11.4.1.2 Japan 9 www.bisresearch.com  sales@bisresearch.com

10. 11.4.1.3 India 11.4.1.4 Australia 11.4.1.5 Taiwan 11.4.1.6 Rest of APAC 11.5 Rest of the World (RoW) 11.5.1 RoW GERD Drug Market by Country 11.5.1.1 Brazil 11.5.1.2 Mexico 11.5.1.3 KSA 11.5.1.4 U.A.E. 11.5.1.5 Russia 11.5.1.6 Iran 11.5.1.7 Turkey 11.5.1.8 Israel 11.5.1.9 Rest of RoW 12 Company Profiles 12.1 AstraZeneca PLC 12.2 Johnson & Johnson 12.3 Pfizer Inc. 12.4 Takeda Pharmaceutical Company Limited 12.5 Novartis AG 12.6 Merck & CO., Inc. 12.7 GlaxoSmithKline Plc 12.8 Eisai Co., Ltd. 12.9 Boston Scientific Corporation 12.10 Ironwood Pharmaceuticals, Inc. 12.11 Valeant Pharmaceuticals International, Inc. 12.12 Cempra Inc. 12.13 Teva Pharmaceuticals Industries Limited. 12.14 Medtronic Inc. 12.15 Medigus Ltd. 12.16 EndoGastric Solutions Inc. 12.17 EndoStim Inc. 12.18 Jeil pharmaceutical Co. Ltd. 12.19 Mederi Therapeutics Inc. 12.20 Torax Medical 16 10 www.bisresearch.com  sales@bisresearch.com

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