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Nicotine Exposure A Toxicological Profile

Presentation Overview. Sources of nicotine exposureToxicant: NicotineHow is nicotine metabolizedToxicity and TargetsConclusion. Sources of Nicotine Exposure. Cigarette SmokingMany toxic constituents

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Nicotine Exposure A Toxicological Profile

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    1. Nicotine Exposure – A Toxicological Profile Presented By Matt DesRoches

    2. Presentation Overview Sources of nicotine exposure Toxicant: Nicotine How is nicotine metabolized Toxicity and Targets Conclusion

    3. Sources of Nicotine Exposure Cigarette Smoking Many toxic constituents – nicotine is highly addictive Around 10 mg in most cigarettes – Smoker inhales 1-2 mg Exposure route - Inhalation

    4. Sources of Nicotine Exposure Smokeless tobacco Chewing tobacco (absorption through gums) 4.6 mg Snuff (inhalation through nose) 3.6 mg Less common but still many toxic constituents

    5. Sources of Nicotine Exposure Smoking cessation medication Nicotine chewing gum (absorption through gums) 2 – 4mg The transdermal patch (absorption through skin) 5 – 30 mg over 24 hours Nicotine inhaler - 10 mg per cartridge To deliver nicotine and wean off

    6. Sources of Nicotine Exposure 4. Ingestion of these products Many cases of children eating cigarettes or consuming spittle from chewing tobacco Intentional – swallowing chewing tobacco spittle

    7. Sources of Nicotine Exposure Occupational exposure Tobacco leaf harvest/handling - Green Tobacco Sickness (absorption) Pesticide application (absorption, inhalation, ingestion) – nicotine sulfate - Not as common today

    8. Nicotine

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