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図  2型糖尿病 患者における膵 β 細胞機能の経年的低下

図  2型糖尿病 患者における膵 β 細胞機能の経年的低下. 診断前から 経年的に低下. スルホニル尿素薬 ( n=511 ). (%). メトホルミン ( n=159 ). 100. 診断時点で 50 %低下. 食事療法 ( n=110). 80. β. 細胞機能. 60. 40. a ). 20. 0. (年). –5. –4. –3. –2. –1. 0. 1. 2. 3. 4. 5. 6. 診断後経過年数.

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図  2型糖尿病 患者における膵 β 細胞機能の経年的低下

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  1. 図 2型糖尿病患者における膵β細胞機能の経年的低下図 2型糖尿病患者における膵β細胞機能の経年的低下 診断前から経年的に低下 スルホニル尿素薬(n=511) (%) メトホルミン (n=159) 100 診断時点で50%低下 食事療法(n=110) 80 β 細胞機能 60 40 a) 20 0 (年) –5 –4 –3 –2 –1 0 1 2 3 4 5 6 診断後経過年数 a) HOMA-β(homeostasis model assessment for beta cell function)を指標 UKPDS Group: Diabetes 44, 1249-1258, 1995 (UKPDS16) より改変

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