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Relative Amount

A. ProPCSK9. Non- specific. mPCSK9. *. 2.0. *. *. *. *. *. 1.5. Relative Amount. 1.8. 1.7. 1.0. 1.6. 1.5. 1.4. 1.3. 0.5. 1.1. 1.1. 1.0. 1.0. 1.0. 1.0. 0.0. 0. 0.01. 0.05. 1. 5. 10. B. sPCSK9. 2.0. 2.0. 1.5. 1.5. C. Relative Amount. 1.6. 1.6. 1.0. 1.0.

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Relative Amount

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  1. A ProPCSK9 Non- specific mPCSK9 * 2.0 * * * * * 1.5 Relative Amount 1.8 1.7 1.0 1.6 1.5 1.4 1.3 0.5 1.1 1.1 1.0 1.0 1.0 1.0 0.0 0 0.01 0.05 1 5 10 B sPCSK9 2.0 2.0 1.5 1.5 C Relative Amount 1.6 1.6 1.0 1.0 LDLR 1.5 1.5 1.5 1.5 1.4 1.4 0.5 0.5 * 1.0 1.0 1.0 1.0 * 3.0 3.0 3.0 3.0 0.0 0.0 2.5 2.5 2.5 2.5 0 0 0.01 0.01 0.05 0.05 1 1 5 5 10 10 10 * 2.0 2.0 2.0 2.0 Relative Amount 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 1.5 1.5 1.5 1.5 2.0 2.0 2.0 2.0 1.0 1.0 1.0 1.0 1.1 1.1 1.1 1.1 0.5 0.5 0.5 0.5 1.1 1.1 1.1 1.1 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0 0.01 0.01 0.01 0.01 0.05 0.05 0.05 0.05 1 1 1 1 10 10 10 10 5 5 5 5 Simvastatin µM

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