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1984 Founded Microbiology Testing Start Up 1987: Analytical Chemistry Division Launch

Background. 1984 Founded Microbiology Testing Start Up 1987: Analytical Chemistry Division Launch 1992: Moved to new 7500 Sq ft lab 1996: Launched Research Micro Division; added 3000 sq ft lab 1997: Founded Bio-One Sciences Pharma Research & Development

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1984 Founded Microbiology Testing Start Up 1987: Analytical Chemistry Division Launch

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  1. Background • 1984 Founded Microbiology Testing Start Up • 1987: Analytical Chemistry Division Launch • 1992: Moved to new 7500 Sq ft lab • 1996: Launched Research Micro Division; added 3000 sq ft lab • 1997: Founded Bio-One Sciences • Pharma Research & Development • 1998: Expanded into Clean Room micro area; added 5000 sq ft • 2003: Expanded bio-pharma manufacturing with rBOT-A vaccine manufacture. • 2005: Launched analytical virology division; added 20,000 sq ft • 2007: Launched pharma stability testing division; added 20,000 sq ft • 2010: Launched molecular biology with real time PCR release testing and bacterial/fungal genetic testing 85 Employees www.microtestlabs.com

  2. Bio One Sciences Projects • Beach at Home: Cosmetic used in skin tone applications (natural product) – launched 1998 • Zebra Fish for Medical Device Toxicology Screening • Translation to commercial through Microtest • Biofilm Reduction in Pharma Water System • Bio-1067 is a quorum sensing disrupter that reduces “persister organisms” by inactivating quorum sensing molecules (acyl-HSL) homoserine lactone. • Translation to commercial: Manufacture and distribution of Biofilm treatment products • Biofilm organisms communicate instability in the colony, an epigenetic gene pathway is activated that induces persister organisms. Biofilm destruction is difficult with quorum sensing conserved.

  3. Solutions • Scope: Biofilm produced by planktonic organisms are fouling biopharm/pharma water systems causing millions of dollars of cleaning and down time • Current Problem: Manufacturer’s use enzyme cleaning, bleach, NaOH and other chemicals to treat biofilm. Manufacturing down time equates to 100 of millions in lost revenue per year. • Solutions: Investigate compounds that will deregulate the persister pathway. Therefore, allowing the chemical treatment to destroy the biofilm. • Bio One Compound BIO-1017 is designed to disrupt quorum sensing molecules required to induce persister organism state.

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