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Cytosolic [Ca]

RyR2 open probability. Iso. CHF. ECC gain Ca transient contractility. [Ca]. DADs - SCD. Cytosolic [Ca]. Time. Excitation-secretion coupling Inositol 1,4,5-trisphosphate receptors. IP3 signaling. Stable transfectant Jurkat T cells do not express IP3R1. IP3R1.

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Cytosolic [Ca]

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  1. RyR2 open probability Iso CHF ECC gain Ca transient contractility [Ca] DADs - SCD Cytosolic [Ca] Time

  2. Excitation-secretion coupling Inositol 1,4,5-trisphosphate receptors

  3. IP3 signaling

  4. Stable transfectant Jurkat T cells do not express IP3R1 IP3R1

  5. Activation of IP3-gated Ca2+ channel by fyn

  6. Calcium signaling during apoptosis Growth Factor Plasma Membrane PIP2 Rec PLC- g Cytoplasm P IP3 14-3-3 P 2+ ER Bad Ca Bad B c l - 2 Degradation IP3R S ERCA 2+ Akt Ca + X ? Calcineurin Cytosolic T F B c l - 2 B c l - 2 B c l - 2 Bad DNA CAD Bcl-x Digestion Nuclear Caspases TF M M Cytochrome C Nucleus Cytoskeletal Breakdown Survival Survival Cell Death

  7. NCE mM [Ca] mitochondria nAChR CNG VDAC Stretch receptor Endoplasmic reticulum mM [Ca] PMCA IP3R SERCA 100 nM [Ca] T-tubule mM [Ca] Sarcoplasmic reticulum VGCC RyR SERCA

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