1 / 20

Lesioni a cellule colonnari CON atipie (FEA/DIN1A)

Lesioni a cellule colonnari CON atipie (FEA/DIN1A). Lesioni a rischio evolutivo?. SI. Escissione sempre?. ?. Clinical problems : to excise or not to excise CCC?. The limited available data suggest that when atypia is encountered in a core needle biopsy specimen,

bobby
Download Presentation

Lesioni a cellule colonnari CON atipie (FEA/DIN1A)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Lesioni a cellule colonnari CON atipie (FEA/DIN1A) Lesioni a rischio evolutivo? SI Escissione sempre? ?

  2. Clinical problems: to excise or not to exciseCCC? The limited available data suggest that when atypia is encountered in a core needle biopsy specimen, subsequent excision shows a more advanced lesion in about 1/3 of cases. This is sufficiently frequent to recommend excision in such cases as a matter of routine Breast Cancer Res 2003; 5:263-268

  3. Margin evaluation: CCL with atypia should not be taken into consideration even when they are composed of cells that are cytologically similar to those in the diagnostic areas of clinging DCIS. Advances in Anatomic Pathology 2003; 10: 113-124

  4. FEA/ADH/CDIS/DIN??????????????????????????????

  5. Virchows Arch (2007) 451:883–891 The term “flat” refers to the overall architecture of the proliferation, which lacks any intraluminal protrusions in the form of arcades, bridges, or micropapillae and is essential in distinguishing this lesion from ADH.

  6. ADH DIN1B FEA DIN1A

  7. Modern Pathology (2009) 1–8

  8. Modern Pathology (2009) 1–8

  9. Modern Pathology (2009) 1–8

  10. Management CCL/FEA 1. CCL without atypia BENIGN 2. Multidisciplinary approach for FEA managing 3. Surgery recommended when CCL without atypia or FEA are associated with other risk lesions (ADH/LIN) on VACB; 4. Excision biopsy not mandatory only when histopathological findings are concordant with the radiological features and flat epithelial atypia is found on VACB as the most advanced lesion.

  11. FOLLOW UP?

  12. Virchows Arch (2007) 451:883–891 close followup is advised with repeat mammogram every 6 months for 2–3 years for early detection of any such invasive carcinomas in the vicinity of flat DIN 1.

  13. Management CCL/FEA 1. Multidisciplinary approach 2. Surgery recommended when CCL without atypia or FEA are associated with other risk lesions (ADH/LIN) on VACB; 3. Excision biopsy not mandatory only when histopathological findings are concordant with the radiological features and flat epithelial atypia is found on VACB as the most advanced lesion. 4. women should be advised of the possible hormone dependency of CCLs.

  14. 3D reconstruction of an atypical cystic lobule ER(red) and Ki67(green) in CCL

  15. Laboratory Investigation (2008) 88, 938–948

  16. CCL Not CCL

More Related