1 / 16

DR Beth PAYNE

Fishing for answers to DBA. DR Beth PAYNE. Who am I?. Haematology Consultant at University College London Hospital/Research at UCL CI. Why am I here. Trained in Haematology in Glasgow and London 2006 went to Harvard Medical School in Boston, USA Became interested in studying DBA.

bono
Download Presentation

DR Beth PAYNE

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Fishing for answers to DBA DR Beth PAYNE

  2. Who am I? • Haematology Consultant at University College London Hospital/Research at UCL CI

  3. Why am I here • Trained in Haematology in Glasgow and London • 2006 went to Harvard Medical School in Boston, USA • Became interested in studying DBA

  4. Researching what goes wrong in DBA – WHAT DO WE KNOW? • Red blood cells die prematurely

  5. Researching what goes wrong in DBA – WHAT DO WE KNOW? • Mistakes or absence one copy of a group of genes • These genes code for ribosomal proteins US National library of Medicine

  6. Researching what goes wrong in DBA – WHAT WOULD WE LIKE TO KNOW? • Since ribosomes are needed in all cells, why does DBA only cause problems with red blood cells? • Can we use research to help us find new treatments ?

  7. How to answer our questions? • Patients and their families are the greatest teachers • Some experiments cannot be done on patients so we need to learn more using other laboratory models

  8. Zebrafish

  9. Why do we use zebrafish? RO Karlstrom and DA Kane A flipbook of zebrafish embryogenesis Development (1996) 123:461

  10. Why do we use zebrafish? 2mm

  11. Why do we use zebrafish?

  12. Zebrafish Embryo stained for Haemoglobin at 4 days

  13. Effects of Leucine in DBA zebrafish

  14. Growth of DBA zebrafish with leucine

  15. Use Red fluorescent DBA zebrafish Ongoing projects – using DBA zebrafish to find new drugs for DBA Assess candidate compounds in primary cells

  16. Acknowledgements DFCI/Harvard Medical School USA Tom Look Evisa Gjini UjwalPyati Hong Sun AratiKhanna-Gupta Nancy Berliner AnuNarla Ben Ebert UCL Maria Virgilio Greg Pietka YoungrockJoung Tariq Enver Steve Wilson David Linch St Marys/Imperial College Josu De La Fuente DBA Patients and families!!!

More Related