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Release. Extension. Contraction. Attachment. Recycling. x. t. e. i. o. C. o. n. t. r. a. c. t. i. o. n. F. o. r. c. e. F. o. r. c. e. R. e. l. e. a. s. e. R. e. c. y. c. l. i. n. g. Attachment and Contraction. FN Bead Binding Movement and Release.

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  1. Release Extension Contraction Attachment Recycling x t e i o C o n t r a c t i o n F o r c e F o r c e R e l e a s e R e c y c l i n g

  2. Attachment and Contraction

  3. FN Bead Binding Movement and Release Displacement

  4. How does a cell treat the ECM?

  5. Unstressed Attachments Choquet et al., Cell. 88:39 (1997)

  6. Force Causes Reinforcement

  7. Force Causes GFP-Paxillin Accumulation in RPTPa+/+ with FN Without Force FN Bead Con A Bead

  8. RPTPa Deletion Blocks But Transfection Restores Binding -/- Cells with Force -/- Transfected wtRPTPa

  9. Substrate Rigidity Can Control Direction of Motility Non-Rigid Rigid

  10. Horwitz, Scientific American

  11. Summary of Course Lectures 1-Intro2-Diffusion3-Diff.Transport4-Nuclear Organization5.Nuc.Binding6 DNA Replication7 RNA Transcription8-RNA FactorBind.doc9-Fluid Bilayer10-Guoy-Chapman11-Membrane Potential12 Protein Translation 13-Cytoskeleton 14-Self-Assembly 15-16Molec.Mech.Q.doc 16-Molecular Motors 17-Mechanics 18-Motor Kinetics 19 Protein Translocation 20 Fission and Fusion 21 Proteol-Degrad 22 Signal Integration 23 Cell Migration 24 Cell Motility ()

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