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Fraunhofer MEVIS Institute for Medical Image Computing

Fraunhofer MEVIS Institute for Medical Image Computing. www.mevis.fraunhofer.de Bremen / Lübeck - Germany. Contents. Overview Evolution and structure Fraunhofer MEVIS Innovation chain Perspectives. Field of Work. Computer assistance for image-based, personalized

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Fraunhofer MEVIS Institute for Medical Image Computing

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  1. Fraunhofer MEVISInstitute for Medical Image Computing www.mevis.fraunhofer.de Bremen / Lübeck - Germany

  2. Contents • Overview • Evolution and structure • Fraunhofer MEVIS • Innovation chain • Perspectives

  3. Field of Work Computer assistance for image-based, personalized diagnosis and therapy

  4. Til Mette stern - April 2005

  5. Characteristics • Focus on image-based SW solutionsforclinicians • Whole chain: earlydetection, diagnosis, therapy, monitoring • Epidemiologically important diseases Patient-individual solutions Transdisciplinaryapproach Clinical network • 150+ clinicalandscientificpartnersworldwide Complete innovation chain • basicresearchresearch prototype product Medicine Science Industry

  6. Image Modalities … … MR Spectroscopy, Microscopy/Histology, …

  7. Whycomputersupport?

  8. Whycomputersupport?

  9. Dimensionsof Competence Methods MeVisLab Validation Navigation Riskanalysis Visualization Quantification Segmentation Registration Modeling/Simulation Organs Diseases (Tumor, Inflammation, Degeneration, etc.) Bones/Joints Heart/Vessels Brain Lung Liver ClinicalWorkflow EarlyDetectionDiagnosticPlanningProcedure Monitoring Breast Imaging/Modality Diagnosis Therapy

  10. Fields ofActivity • Algorithms, Software Applications & Computing • Visualization & Human Computer Interaction • Workflow, Clinical Usability, … • Intra-operative/-interventional Support • Liver, Lung, Breast, … • Mathematical Modelling & Numerical Simulation • FoundationProfessorshipat Jacobs University • MR Imaging & Physics • FoundationProfessorshipat University Bremen • Image Registration • Project Group at University Lübeck

  11. 2. Evolution andstructure

  12. MeVis Family Tree University Non-profit Commercial : : 2009 2007 2005 2003 2001 1999 1997 1995 1993 emerged from daughter of

  13. Structuresince 01/2009 Non-profit Commercial(75 employees) (230 employees) 50% Institute forMedical Image Computing Bremen Bremen 41% Bremen 50% NL 100% 100% 51% EFRE 50% Project GroupImage Registration Lübeck(since 04/2010) S-H Bremen USA Japan 50% EFRE

  14. 3. Fraunhofer MEVIS

  15. Fraunhofer Society • Fraunhofer Groups • Information & Communication Technology • Life Sciences • Microelectronics • Surface Technology & Photonics • Production • Materials & Components • Defense & Security • 59institutes in GER • 17 000 employees • about 1.6 billion EURresearchbudget • 2/3 fromindustryandpublicagencies

  16. Itzehoe Rostock Lübeck Bremen Berlin Potsdam Hannover Teltow Nuthetal Braunschweig Magdeburg Paderborn Cottbus Oberhausen Halle Dortmund Leipzig Schmallenberg Schkopau Duisburg Dresden Sankt Augustin Aachen Jena Ilmenau Chemnitz Euskirchen Darmstadt Würzburg Erlangen Kaiserslautern Wertheim St. Ingbert Nürnberg Saarbrücken Pfinztal Karlsruhe Stuttgart Freising Freiburg München Holzkirchen Efringen-Kirchen Fraunhofer Society 59 Institutes in GER Institutes Branches, Working Groups,Application Centers Bremerhaven

  17. Organization Chart

  18. Organizationof Work • Team-oriented • Open-minded • Self-organized • Flexible • Adaptive

  19. Advisory Board of Fraunhofer MEVIS Chair: Dr. R. Jansen Dr. U. Niebling Dr. C.J.G. Evertsz Dr. B. Gewiese Prof. Dr.-Ing. E.R. Reinhardt ResearchFunding: Prof. Dr. H. Maier W. Märzendörfer Industry:

  20. Advisory Board of Fraunhofer MEVIS Science: Prof. Dr. G. Székely Medicine/Clinic: Prof. Dr. H.-P. Schlemmer Prof. Dr. J. Hennig Prof. Dr. W.A. Kalender Prof. Dr. R. Kikinis Uni Bremen: Jacobs University: Dr. A. Ziegler-Jöns Prof. Dr. J. Falta Prof. Dr. H.-P. Bruch Prof. Dr. U. Sure Prof. Dr. M. Reiser Prof. Dr. K.J. Klose

  21. Management Board Prof. Dr. Heinz-Otto PeitgenProf. Dr. Horst K. HahnDipl.-Betrw. Thomas Forstmann Institute DirectorDeputy Institute Director Head of Administration Prof. @ Uni Bremen Adj. Prof. @ Jacobs Uni Prof. @ Uni BocaRaton Research Prof. Dr. Matthias GüntherProf. Dr. Tobias PreußerProf. Dr. Bernd Fischer Head of MR Imaging Head of Modeling & Simulation Head of PG Image Registration Found.Prof. @ Uni Bremen Found.Prof. @ Jacobs Uni Head of MIC Institute Prof. @ Uni Lübeck Dr. Stefan KraßDr. Markus LangDr. Guido Prause Clinical cooperations Scientific personell Publiclyfundedprojects IndustryprojectsIndustryprojectsPR / Advisory Board Publiclyfundedprojects IPR / contractsDeputy Head of Administration

  22. Extended Management Board • Personsof Trust • Melanie Bohn • Bianca Lassen • Lars Bornemann • Dr. Benjamin Geisler • Dr. Jan-Martin Kuhnigk • IT, Software Development • Dr. Stephan Zidowitz • Quality Management 22

  23. Finance(MEVIS Bremen) TEUR Inv. BHH HB HB HB EFRE HB HB HB

  24. Personnel(MEVIS Bremen) MMS: ≈ 230 CeVis: ≈ 10

  25. Certification Certificateforqualityassurance(since 2005) • Introductionandapplicationof a qualitymanagementsystem in compliancewith • EN ISO 9001 / 12.2000 • EN ISO 13485 / 07.2003 (medicaldevices) Scope: • Research and development for image-based medical diagnosis and therapy • Development of software

  26. Awards Scientific Exhibit Award withCertificateofMerit(Radiological Society of North America) Bundesverdienstkreuz erster Klasse für Prof. Peitgen(Bundespräsident Roman Herzog) Karl Heinz Beckurts-Preis für Forschung und Innovation(Karl Heinz Beckurts-Stiftung) Magna Cum Laude Award for Most Innovative Contribution(European CongressofRadiology) Werner Körte Medaille in Gold(Deutsche Gesellschaft für Chirurgie) Bremer Unternehmerpreis für Wissenstransfer (ASU, BJU) Inductionof Prof. Peitgen into Hall ofFameat FAU Deutscher Gründerpreis 2006(Sparkasse, McKinsey, stern, ZDF) Eurographics 2007 Medical Prize Bernd-Artin Wessels-Preis 2007 RSNA 95/97/00-02: Oct1996: Dec1999: Mar 2005: Apr 2005: Mai 2005: Feb 2006: Sep 2006: Sep 2007: Nov 2007:

  27. German FoundersPrize2006 Sep 12, 2006: ZDF studio in Berlin

  28. 4. Innovation chain

  29. Europe, Asia, USA Innovation Chain Siemens Hologic Clinical Network >150 Invivo OUTPUT INPUT Philips Toshiba

  30. MeVisLab:SW Platform for R&D, Prototyping, Evaluation & Integration R&D Structureat MeVis Algorithmic Development : : Customization Integration Algorithm Idea Prototype Network Product Technical Testing Clinical Testing Clinical Evaluation

  31. PubliclyFunded Projects

  32. CooperationswithIndustry • Fraunhofer MEVIS • MMS AG • Siemens AG • Stryker • severalothers in publiclyfundedprojects • OEM partnersof MMS AG • Siemens AG • Hologic • Philips/ Invivo • Toshiba

  33. ThreeSuccessStories Market share >50% Breast-MRI - Neoangiogenesisand Biopsy >50% Breast Cancer Screening - Digital Mammography Surgery Planning - Internet-based Service >90%

  34. 1. Breast-MRI: Tumor Dynamic & Biopsy

  35. 2. Mammography Workstation Softcopy reading in digital mammography First prototype:master thesis EU Projects: - SCREEN - SCREEN-TRIAL Mammography Screening Bremen Today: World market leader with over 6.000 systems Siemens: MammoReportPlus Reporting Station Hologic: LORAD Selenia Reporting Station

  36. 3. LiverSurgeryPlanning

  37. Distant Service via Internet USA Japan Europe Korea Egypt Australia China Taiwan certified Singapore

  38. 150+ Users Worldwide Asia, USA, Europe Germany • Kyoto University Hospital, Japan • Yokohama City University Medical School, Japan • Nagoya University Hospital, Japan • University Hospital Kanazawa, Japan • Kaohsiung University Hospital, Kaohsiung, Taiwan • LaheyClinic, Burlington, MA, USA • Massachusetts General Hospital, Boston, MA, USA • University ofCaliforniaat San Francisco, USA • Columbia University, USA • University of Michigan, USA • UniverstityofCaliforniaat Los Angeles, USA • Washington University St. Louis, USA • Strong Memorial Hospital, Rochester, NY, USA • NIH Clinic, Bethesda, MD, USA • State University Hospital, Groningen, Netherlands • Lund University Hospital, Sweden • Verona University Hospital, Verona, Italy • Naples University Hospital, Naples, Italy • Univerity Hospital SapienzaRome, Italy • Gleneagles Hospital, Singapore • Charité Berlin, Campus Benjamin Franklin • Charité Berlin, Campus Buch • Charité Berlin, Campus Virchow • Allgemeines Krankenhaus Celle • Universitätsklinikum Essen • Johann Wolfgang Goethe Universität Frankfurt • Universitätsklinik Freiburg • Medizinische Hochschule Hannover • Klinikum Hof • Universitätsklinik Köln • Klinikum Krefeld • Klinikum Schleswig-Holstein, Campus Lübeck • Universitätsklinikum Mainz • Klinikum der Philipps-Universität Marburg • Klinikum rechts der Isar München • Universitätsklinik Tübingen Status since 2003: > 5.000 planningsat MeVis ≈ 2.400 LDLTs ≈ 1.900 Tumor resections ≈ 700 Pancreas, kidney, spleen, …

  39. 5. Perspectives

  40. Perspectives • New fields • Modeling andsimulation • MR imaging • Image registration • Personnel • 82+ employeesuntil 2013 at Fraunhofer MEVIS • MR Scanner • MeVis Campus

  41. Modeling and Simulation • Jacobs University Bremen • Foundationprofessorshipby Conrad and Lotti Naber • Modeling of bio-physicalprocesses • Numericalsimulation • Examples • RF-Ablation oflivertumors • Numericalflowsimulation • High focusedultrasound Prof. Dr. Tobias Preußer

  42. MR Imaging & Physics • University Bremen – FB Physics • FoundationprofessorshipbyStiftung Bremer Wertpapierbörse • Optimizationofimaging • Development ofnewsequencesandimagingprotocols • Examples • Arterial Spin-Label Imaging • Diffusion Tensor Imaging Prof. Dr. Matthias Günther

  43. Image Registration • Fraunhofer MEVIS – Project Group Lübeck University Lübeck – Institute ofMathematics • Basic fundingby State Schleswig-Holstein • Anatomicallycorrectmappingandfusionofmedicalimagedata • Examples • Registration ofpre-, intra- und postoperative images • Multimodal imageregistration Prof. Dr. Bernd Fischer

  44. www.mevis.fraunhofer.de • EUROPEAN UNION: • Investing in your future • European Regional Development Fund

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