Particle Size Introduction and Definitions

Particle Size Introduction and Definitions Kausar Ahmad Kulliyyah of Pharmacy, IIUM Physical Pharmacy 2

Contents • Effect of particle size, shape • Sampling • The significance of sampling • How to take a sample • Definitions • Particle size distribution • Average • Polydispersity • Monomodal, bimodal, skewed Physical Pharmacy 2

Effect of Particle Size Physical Pharmacy 2

Definitions of Particle Shape Physical Pharmacy 2

Effect of Particle Shape Physical Pharmacy 2

Effect of Particle Shape on Size Physical Pharmacy 2

SEM pictures of polystyrene Physical Pharmacy 2

SEM picture Al2O3 Agglomerated Al2O3 Physical Pharmacy 2

Types of samples Physical Pharmacy 2

Sampling of Powders • Characteristics of many tons of material are assumed on the basis of analyses carried out on grams or milligrams. • Bias at any stage will affect final analysis. • Therefore, a sampleshould represent the bulk. Physical Pharmacy 2

Bulk Sampling – Type of Material Physical Pharmacy 2

Type of sampling Sampling from container Sampling from big bags Physical Pharmacy 2

Sampling from bag/sack/drum • Inspect condition of bags • Select bags at random • Scoop sampling is widely used method due to its simplicity. • It is supposed that the powder, at the point at which the scoop is inserted, represents the bulk • Increase accuracy by having more than one sample (CHECK how this is done @ pilot plant) See http://www.kersting-ind.de/uploads/media/Pharma__UDS_engl.pdf Physical Pharmacy 2

On-line Sampling • Normally taken during the process • For quality control purpose/IPQC, samples should be taken only when the process has stabilised • Samples taken from different sampling point e.g. on a conveying belt or screw Physical Pharmacy 2

Sampling from Emulsion & Suspension • Samples must be stirred before samples are taken • Accuracy increases with more than one sample Physical Pharmacy 2

Definitions of Particle Size Physical Pharmacy 2

Average Particle Size Physical Pharmacy 2

Average Diameter Physical Pharmacy 2

Example of PSD: Particles with different diameters. Physical Pharmacy 2

Polydispersity Index/Span/Width Physical Pharmacy 2

PSD – Perfluorocarbon emulsion Polydisperse Physical Pharmacy 2

PSD - LiposomePL-PSDA (Polymer Lab: HDC mechanism) Skewed to the right Physical Pharmacy 2

PSD – Colloidal silica Skewed to the left Physical Pharmacy 2

PSD - PVC Latexoverlay of two sample distributions Almost monodisperse High polydispersity index Physical Pharmacy 2

PSD - Polystyrene Latex Blend Bimodal distribution Physical Pharmacy 2

PSD - n-butyl acrylate latex overlay of sequential samples taken from reactor initial final Physical Pharmacy 2

References KeishiGotoh et al, Powder Technology Handbook 2nd Ed., Marcel Dekker, New York (1997) Muhammad E Fayed & Lambert Otten, Handbook of Powder Science & Technology 2nd Ed., Chapman & Hall, New York (1997) ME Aulton, Pharmaceutics: The Science of dosage form design, Churchill Livingstone, London (1988). Chap 33, p 564, p 581 http://www.polymerlabs.com/partsize/psdaapps.htm Physical Pharmacy 2

Particle Size Introduction and Definitions

Particle Size Introduction and Definitions

Presentation Transcript

Definitions and Introduction:

Introduction/Definitions

Psychology: Introduction and Definitions

Particle Size Analysis

Definitions and Introduction:

Introduction and Basic Definitions

Particle Size Analysis

Particle Size Analysis

Particle size measurement

Particle size

Introduction and Definitions

Fundamental Particle Definitions

Particle Size Distribution (PSD)

Particle-size analysis

CHAPTER 1 Introduction: Definitions and History

5.1 Introduction and Definitions (1)

Particle Size Analysis

Image particle shape and size analyzer