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Cross-sensitization to drugs of abuse

Cross-sensitization to drugs of abuse. **. Sugar-bingeing rats are hyperactive in response to a low dose of amphetamine. Sugar-bingeing rats consume more alcohol. . Avena and Hoebel (2003); Avena et al . (2004).

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Cross-sensitization to drugs of abuse

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  1. Cross-sensitization to drugs of abuse ** • Sugar-bingeing rats are hyperactive in response to a low dose of amphetamine. • Sugar-bingeing rats consume more alcohol. Avenaand Hoebel (2003); Avena et al. (2004)

  2. Food variety attenuates habituation to food in humans...when you have variety, you eat MORE.

  3. Geiger et al. (2009) • Rats with access to a cafeteria-style diet are hyper-responsive to amphetamine in terms of dopamine release. • However, they do not respond to a lab chow meal. These rats need “junk food” to release accumbens dopamine.

  4. Assessing “Food Addiction”In Clinical Samples

  5. Yale Food Addiction Scale • The Yale Food Addiction Scale (YFAS) has been created to study food addiction by applying the DSM-IV criteria for substance dependence to eating behaviors • Questions are answered using a Likert type scale (i.e., Never, Once a month, 2-4 times a month, 2-3 times a week, 4 or more times or daily) • Sample items: • “I find myself continuing to consume certain foods even though I am no longer hungry” • “I eat to the point where I feel physically ill” • “I find that when I start eating certain foods, I end up eating much more than planned”

  6. Select Findings from Studies using the Yale Food Addiction Scale • In a group of about 200 undergraduate students, 11.4% met the criteria for food addiction (Gearhardt et al., 2009) • Among 72 obese participants, 25% met the criteria for food addiction (Davis et al., 2011) • Two studies assessing food addiction symptoms in obeseindividuals with binge eating disorder reported that 42-57% met the criteria for food addiction (Gearhardt et al., 2012; 2013) • Recently, this scale has been adapted to use in children and adolescents. A preliminary study using the YFAS-C found 7.2% of the 72 children and adolescents met the criteria for food addiction (Gearhardt et al., 2013)

  7. Correlates of Food Addiction Include… • Binge eating disorder (BED) / binge eating • Depression • Impulsivity • Lower self-esteem • Emotional eating • Food cravings • Snacking on sweets • Mixed evidence regarding weight loss outcomes

  8. - Summary - Allen et al. (2012)

  9. How might we manage food addiction?

  10. Managing Food Addiction 1. One step to managing food addiction is preventing it by altering certain social norms surrounding food, such as… • Using food as reinforcements with children • Having food as the central part of most social gatherings • Including popular toys in unhealthy food packages to market toward children As a society, we have to stop being “food pushers”

  11. Managing Food Addiction 2. We have to become savvy food consumers by: • Understanding nutrition labels • Knowing where sugars are hidden • Following new research findings 3. Pharmacological approaches: Researchers are currently studying pharmacological agents known to target brain regions associated with reward (i.e., dopaminergic and opioidergic systems) in order to identify possible drug treatments that may suppress overeating, particularly of highly palatable foods.

  12. Managing Food Addiction Going “Cold Turkey” might not work for everyone when it comes to food. • Phase out items slowly to reinforce a lifestyle change, not a diet • Have suggestions for satisfying alternatives • Don’t mistake “withdrawal” for “low blood sugar” or hunger • Anticipate and cope with cravings

  13. Managing Food Addiction In addition to the social and neurochemical aspects involved in foodaddiction, there may also be important psychological reasons thatpeople may develop an unhealthy relationship with food. In order to address these factors, it may be helpful to recognize: • When do we typically overeat (when we are bored? stressed? depressed? lonely? in groups?) • When did this pattern of overeating first begin? • What function might overeating serve for us? We have a lot more work to do to understand how to manage food addiction

  14. Conclusions • There are behavioral and neurochemical overlaps between excessive intake of palatable food and drug abuse. • These overlaps may help to explain patterns of overeating • which may contribute to obesity • in some cases of BED and bulimia nervosa • Further study is needed to better understand how food addiction can be prevented and managed among patients.

  15. Thank you! Students: Miriam Bocarsly Susan Murray Alastair Tulloch Monica Gordillo Eric Su Stephanie Yarnell Elyse Powell Collaborators: Mark Gold Pedro Rada Sarah Leibowitz Contact: nicoleavena@gmail.com DrNicoleAvena.com

  16. Q & A

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