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Epidemiology of Colorectal Cancer

Epidemiology of Colorectal Cancer. Rajiv Kumar Advanced Trainee in Medical Oncology Wellington Blood & Cancer Centre Wellington Hospital 14 September 2014. WHO 2000. Cancer Registrations 2005. Age-standardised registration rate (per 100 000) Breast 48.0 CRC & anus 47.1

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Epidemiology of Colorectal Cancer

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  1. Epidemiology of Colorectal Cancer Rajiv Kumar Advanced Trainee in Medical Oncology Wellington Blood & Cancer Centre Wellington Hospital 14 September 2014

  2. WHO 2000

  3. Cancer Registrations 2005 • Age-standardised registration rate (per 100 000) • Breast 48.0 • CRC & anus 47.1 • Melanoma 38.8 • Trachea,bronchus,Lung 29.3 http://www.moh.govt.nz

  4. Cancer Registrations 2005 Men Women • Age-standardised registration rate (per 100 000) • Prostate 95.0 • CRC & Anus 50.7 • Melanoma 44.3 • Trachea,Bronhus,Lung 35.7 • Age-standardised registration rate (per 100 000) • Breast 92.0 • CRC & Anus 43.9 • Melanoma 34.3 • Trachea,Bronhus,Lung 24.1 Prostate 25.6% Colorectal & Anus 13.8% Melanoma of skin 11.5% Trachea,Lung,bronchus 9.8% NHL 3.9% MPS/MDS 3.6% Leukaemia 3.4% Urinary bladder 2.6% Kidney 2.3% Stomach 2.1% All Other Sites 21.4% 27.4% Breast 15.5% Colorectal & Anus 10% Melanoma of skin 7.9% Trachea,Lung,Bronchus 4.3% Uterine corpus 3.5% NHL 3.4% Ovary 3.1% MPS/MDS 2.7% Leukaemia 2.3% Pancreas 19.8% All Other Sites http://www.moh.govt.nz

  5. Cancer Deaths 2005 • Age-standardised death rate • (per 100 000) • Trachea,Bronchus,Lung 25.0 • CRC & anus 19.1 • Breast 11.6 • Prostate 8.3 http://www.moh.govt.nz

  6. Cancer Deaths 2005 Men Women • Age-standardised death rate (per 100 000) • Trachea,Bronchus,Lung 32.3 • CRC & Anus 22.6 • Prostate 19.9 • Age-standardised death rate (per 100 000) • Breast 21.7 • Trachea,Bronhus,Lung 19.2 • CRC & Anus 17.7 Trachea,Lung,bronchus 20.7% Colorectal & Anus 14.5% Prostate 13.5% Pancreas 4.3% Leukaemia 3.8% Melanoma of skin 3.7% NHL 3.7% Stomach 3.4% Brain 3.2% Oesophagus 3.1% Bladder 2.9% All Other Sites 23.2% 17.1% Breast 16.2% Colorectal & Anus 15.5% Trachea,Lung,Bronchus 5.0% Ovary 4.6% Pancreas 3.9% Leukaemia 3.0% Melanoma of skin 3.0% Somtach 2.9% NHL 2.3% Brain 2.1% Uterine corpus 19.8% All Other Sites http://www.moh.govt.nz

  7. CRC & Anus Registrations and deaths 1995 - 2006 http://www.moh.govt.nz

  8. Incidence of CRC by age Stratified by age 2005 http://www.moh.govt.nz

  9. CRC & Anus by Ethnicity / Sex 2005 http://www.moh.govt.nz

  10. Dukes Classification A C B D 5yr survival 93% 72 – 85% 44 – 83% 8%

  11. Stage at resection • CRC staging at time of resection from NZCR 2000 • More node positive & muscosal invasion at diagnosis • Low rates of early stage diagnosis = poor survival • Idea that screening would shift the stage at diagnosis  Better survival Keating, J., et al., The epidemiology of colorectal cancer: what can we learn from the New Zealand Cancer Registry? N Z Med J, 2003. 116(1174): p. U437

  12. SUMMARY • Significant problem in NZ • Incidence 47.1 per 100 000(2nd most common) • Mortality 19.1 per 100 000(2nd most common) • Ageing population is an issue in spite of stabilisation of age-standardisation incidence and mortality.

  13. Time Symptomatic disease Asymptomatic disease Screening

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