1 / 10

Sarcoidosis

Sarcoidosis. Bryan Imayanagita 10/22/10 UCI T-RAP. Background. Besnier-Boeck disease Abnormal collection of inflammatory granulomas 20-40 years year old. Scandinavian, blacks Commonly affects lungs. Pathophysiology. Exact cause unknown

brielle-hendrix
Download Presentation

Sarcoidosis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Sarcoidosis Bryan Imayanagita 10/22/10 UCI T-RAP

  2. Background • Besnier-Boeck disease • Abnormal collection of inflammatory granulomas • 20-40 years year old. Scandinavian, blacks • Commonly affects lungs

  3. Pathophysiology • Exact cause unknown • accumulation of monocytes, macrophages and activated T-lymphocytes • Macrophage increase inflammation while immune response suppressed • Genetic Factors: BTNL-2 gene (possibility)

  4. Symptoms • Signs often vague and hard to distinguish • Fatigue, aches, pains, rashes • Enlarged lymph nodes • Mimics cancer • Can be asymptomatic

  5. Diagnosis • Process of elimination • CT, chest X-ray, PET scan to exclude in pulmonary cases • Differential diagnosis: metastatic disease, lymphoma, septic emboli, etc • Women: association with hypo/hyperthyroidism

  6. Stage IV Sarcoidosis

  7. Treatment • 30-70% don’t require treatment • Corticosteroids (prednisone) • Follow up: EKG, liver, calcium tests

  8. Prognosis • Can remit spontaneously or become chronic • Half cured in 12-36 months. Most in 5 years • heart problems • Higher cancer risks

  9. Sources • http://www.merck.com/mmhe/sec04/ch050/ch050e.html • http://www.nhlbi.nih.gov/health/dci/Diseases/sarc/sar_signsandsymptoms.html • http://www.medicinenet.com/sarcoidosis/article.htm

More Related