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Agenda : - Validation vs Pathology Congress presentations & Meetings Paper publication

VI PMT meeting – Feb 1, 2011. Agenda : - Validation vs Pathology Congress presentations & Meetings Paper publication. Validation versus pathology. 1 tracer. Local Protocol : 1.5T 3D T1-weighted scans from (Bobinski et al., 2000) pathologically verified set

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Agenda : - Validation vs Pathology Congress presentations & Meetings Paper publication

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  1. VI PMT meeting – Feb 1, 2011 • Agenda: • - Validation vs Pathology • Congress presentations & Meetings • Paper publication

  2. Validation versus pathology 1 tracer Local Protocol: 1.5T 3D T1-weighted scans from (Bobinski et al., 2000) pathologically verified set (total for rater: 30 hippos) WHICH SAMPLE? Qualification on benchmark images (total for each rater: 40 hippos) Harmonized Protocol: 1.5T 3D T1-weighted scans from (Bobinski et al., 2000) pathologically verified set (total for rater: 30 hippos) RM-ANOVA: test of protocol main effect

  3. Congress presentations & Meetings

  4. Congress presentations - AAN 2012, New Orleans Oral Presentation S04.003, April 24, Aging and Dementia: Therapeutic Interventions, 1.30 pm M Boccardi, M Bocchetta, L Apostolova, J Barnes, G Bartzokis, G Corbetta, C DeCarli, L DeToledo-Morrell, M Firbank, R Ganzola, L Gerritsen, W Henneman, R Killiany, N Malykhin, P Pasqualetti, J Pruessner, A Redolfi, N Robitaille, H Soininen, D Tolomeo, L Wang, C Watson, H Wolf, S Duchesne, CR Jack, GB Frisoni. Delphi consensus on landmarks for the manual segmentation of the hippocampus on MRI: preliminary results from the EADC-ADNI Harmonized Protocol working group. - AAIC 2012, Vancouver Abstract n. 26291, submitted to AAIC 2012 M Boccardi, M Bocchetta, A Redolfi, P Pasqualetti, R Ganzola, N Robitaille, S Duchesne, CR Jack, GB Frisoni and the EADC-ADNI Hippocampal Harmonization Group. Definition of Harmonized Protocol for Hippocampal Segmentation Abstract n. 26292, submitted to AIC 2012 M Boccardi, M Bocchetta, A Redolfi, P Pasqualetti, R Ganzola, N Robitaille, S Duchesne, CR Jack, GB Frisoni and the EADC-ADNI Hippocampal Harmonization Group. Definition of Harmonized Protocol for Hippocampal Segmentation

  5. SOPs periodical meetings AAN – April 24, 2012 AGENDA: 1. Delphi Paper *; 2. Italian-ADNI Paper using prototype-protocol (?) 3. Publication policy AAIC – July 2012 * AGENDA: 1. Presentation of Harmonized Protocol; 2. Reliability figures

  6. 1 tracer VARIABILITY EVALUATION GOLD STANDARD VALIDATION vs PATHOLOGY 5 expert tracers 20 naive tracers Training (tracing 20 hippos on 1.5T ADNI scans with each SU) (SAME on 3T ADNI scans) Local Protocol: Experimental set (1.5T ADNI): 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) Local Protocol: 1.5T 3D T1-weighted scans from (Bobinski et al., 2000) pathologically verified set (total for rater: 30 hippos) Delphi panel → harmonized prot Benchmark Harmonized hippos: 1.5T ADNI scans 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) Qualification (20 tracers) Qualification Harmonized Protocol: 1.5T 3D T1-weighted scans from (Bobinski et al., 2000) pathologically verified set (total for rater: 30 hippos) Harmonized Protocol: Experimental set (1.5T ADNI): 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) global and local 95% confidence intervals AAIC July 2012 Harmonized Protocol: 1.5T ADNI scans 2 sides x 5 Scheltens’s atrophy scores x 3 time points (0-12°month-24°month) x 3 scanners + retracing for timepoint 1 (SAME on 3T ADNI scans) (total for each rater: 240 hippos – including 40 hippos already traced) RM-ANOVA: test of protocol main effect RM-ANOVA: test of main effects side, trace-retrace, atrophy, time, scanner, rater The best 5 naive tracers RM-ANOVA: test of rater and rater by center terms

  7. Papers publication

  8. Next: Paper operationalization Operationalization of differences among protocols for manual hippocampal segmentation M Boccardi, M Bocchetta, R Ganzola, N Robitaille, A Redolfi, S Duchesne, CR Jack , GB Frisoni, and the Alzheimer's Disease Neuroimaging Initiative. Collaborators: G Bartzokis, JG Csernansky, MJ de Leon, L deToledo-Morrell, RJ Killiany, S Lehéricy, N Malykhin, J Pantel, JC Pruessner, H Soininen, C Watson To be submitted to Alzheimer’s and Dementia

  9. Papers describing the project Survey of protocols (preliminary phase; published, JAD 2011) Operationalization (preliminary phase; to be completed) Delphi consensus (Brescia Team) Master tracers’ practice and reliability (Brescia Team) Development of certification platform (Duchesne and coll?) Validation data and Protocol definition (Brescia Team) Validation vs pathology (TBD)

  10. 1 tracer VARIABILITY EVALUATION GOLD STANDARD VALIDATION vs PATHOLOGY 5 expert tracers 20 naive tracers Training (tracing 20 hippos on 1.5T ADNI scans with each SU) (SAME on 3T ADNI scans) Local Protocol: Experimental set (1.5T ADNI): 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) Local Protocol: 1.5T 3D T1-weighted scans from (Bobinski et al., 2000) pathologically verified set (total for rater: 30 hippos) Delphi panel → harmonized prot Benchmark Harmonized hippos: 1.5T ADNI scans 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) Qualification (20 tracers) Qualification Harmonized Protocol: 1.5T 3D T1-weighted scans from (Bobinski et al., 2000) pathologically verified set (total for rater: 30 hippos) Harmonized Protocol: Experimental set (1.5T ADNI): 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) global and local 95% confidence intervals Harmonized Protocol: 1.5T ADNI scans 2 sides x 5 Scheltens’s atrophy scores x 3 time points (0-12°month-24°month) x 3 scanners + retracing for timepoint 1 (SAME on 3T ADNI scans) (total for each rater: 240 hippos – including 40 hippos already traced) RM-ANOVA: test of protocol main effect RM-ANOVA: test of main effects side, trace-retrace, atrophy, time, scanner, rater The best 5 naive tracers RM-ANOVA: test of rater and rater by center terms

  11. VARIABILITY EVALUATION GOLD STANDARD 5 expert tracers 20 naive tracers Local Protocol: Experimental set (1.5T ADNI): 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) Benchmark Harmonized hippos: 1.5T ADNI scans 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) Qualification (20 tracers) Harmonized Protocol: Experimental set (1.5T ADNI): 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) global and local 95% confidence intervals Harmonized Protocol: 1.5T ADNI scans 2 sides x 5 Scheltens’s atrophy scores x 3 time points (0-12°month-24°month) x 3 scanners + retracing for timepoint 1 (SAME on 3T ADNI scans) (total for each rater: 240 hippos – including 40 hippos already traced) RM-ANOVA: test of main effects side, trace-retrace, atrophy, time, scanner, rater The best 5 naive tracers RM-ANOVA: test of rater and rater by center terms

  12. GANTT

  13. 1 tracer VARIABILITY EVALUATION GOLD STANDARD VALIDATION vs PATHOLOGY 5 expert tracers 20 naive tracers Training (tracing 20 hippos on 1.5T ADNI scans with each SU) (SAME on 3T ADNI scans) Local Protocol: Experimental set (1.5T ADNI): 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) Local Protocol: 1.5T 3D T1-weighted scans from (Bobinski et al., 2000) pathologically verified set (total for rater: 30 hippos) Delphi panel → harmonized prot Benchmark Harmonized hippos: 1.5T ADNI scans 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) Qualification (20 tracers) Qualification Harmonized Protocol: 1.5T 3D T1-weighted scans from (Bobinski et al., 2000) pathologically verified set (total for rater: 30 hippos) Harmonized Protocol: Experimental set (1.5T ADNI): 2 x each of the 5 Scheltens’s atrophy score x 2 sides (SAME on 3T ADNI scans) (total for each rater: 40 hippos) global and local 95% confidence intervals Harmonized Protocol: 1.5T ADNI scans 2 sides x 5 Scheltens’s atrophy scores x 3 time points (0-12°month-24°month) x 3 scanners + retracing for timepoint 1 (SAME on 3T ADNI scans) (total for each rater: 240 hippos – including 40 hippos already traced) RM-ANOVA: test of protocol main effect RM-ANOVA: test of main effects side, trace-retrace, atrophy, time, scanner, rater The best 5 naive tracers RM-ANOVA: test of rater and rater by center terms

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