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CRISP AMI

CRISP AMI . Objective To determine if routine intra-aortic balloon pump (IABP) placement prior to reperfusion in patients with anterior STEMI without shock reduces infarct size Study Design Randomized, open-label, multicenter, controlled trial

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CRISP AMI

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  1. CRISP AMI Objective • To determine if routine intra-aortic balloon pump (IABP) placement prior to reperfusion in patients with anterior STEMI without shock reduces infarct size Study Design • Randomized, open-label, multicenter, controlled trial • 337 patients randomized to either IABP prior to PCI (n=161) or standard PCI with “bailout” IABP (n=176) Primary Endpoint • Infarct size as measured by cardiac MRI Secondary Endpoints • All-cause death at 6 months • Vascular complications and major bleeding at 30 days

  2. CRISP AMI Results • Mean infarct size was not statistically significantly different between the patients in the IABP plus PCI group and those in the standard PCI group (42.1% vs 37.5%, respectively; p=0.06) Primary Endpoint

  3. CRISP AMI Conclusions • Compared with PCI alone, IABP plus primary PCI did not result in reduced infarct size among patients with acute anterior STEMI without shock • All-cause mortality at 6 months did not differ significantly between the two groups

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