Collaborative Research and Team Funding:

1. Collaborative Research and Team Funding: Carolee Winstein Professor, Biokinesiology and Physical Therapy Hermon Ostrow School of Dentistry winstein@usc.edu A Tale of Two BIG Projects Navigating the University: Research & Resources Management Retreat @ Descanso Gardens, Friday, August 19th, 2016

2. Two very different examples • Rehabilitation Engineering Research Center (RERC) focused on people aging into or with a disability. [2008-2013] • Partner Clinical Site: • Rancho Los Amigos National Rehabilitation Hospital • Partner Schools/Institutes: • VSoE, Rossier, Gerontology, Keck, Stevens, Cinematic Arts, ICT, ISI, Alfred Mann • Phase 3 Multi-site Randomized Clinical Trial. [2008-2016] Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE) stroke initiative. • Partner Clinical Centers: • National Rehab Hospital, Wash DC; Emory University Center for Rehabilitation Medicine; 5 Southern California Rehabilitation Hospitals • Data Management Center: • USC Preventive Medicine (Team led by Christianne Lane)

3. Sponsor and Budget • RERC—National Institute on Disability and Rehabilitation Research (U.S. Department of Education). [now NIDILRR (U.S. Department of Health and Human Services—National Institute on Disability, Independent Living, and Rehabilitation Research] $950,000/yr total for 5 yrs. • Budget was allocated by project; subcontract to Rancho • Phase 3 Multi-site RCT—NIH NINDS (primary), NICHD (secondary). $12.2 million total for 6 yrs. Used multiple PI option; USC was the Administrative Center issuing subcontracts to the other centers. • Budget included minimal fixed/center, majority was FFS

4. Advisory Board DIRECTORS Carolee Winstein (USC), Philip Requejo (RLANRC) Clinical Translation Florence Clark Gerontology/Policy Eileen Crimmins Dissemination & Technical Assistance Carl Kesselman/Cristina Williams Data Management Steven Cen Training & Education Francisco Valero-Cuevas Assessment & Evaluation Giselle Ragusa Technology Transfer Joseph Koepnick Industrial Partners Projects Activities Beneficiaries P1 Dexterous Manipulation With the Fingertips (Francisco Valero-Cuevas) R1: Strength/Dexterity (S-D) System Aging Into Disability Osteoarthritis Parkinson’s Disease Stroke D1: VR S-D P2 Virtual Reality (VR) and Gaming for Home-Based Motor Assessment & Training (Albert Rizzo) R2: VR Interventions D2: VR Toolkit (VRT) P3 Preserving the Shoulder Complex For Community Mobility in Wheelchair Users (Philip Requejo) D3: VR Home Exercise Program for the Shoulder Complex Aging With Disability Cerebral Palsy Traumatic Brain Injury Spinal Cord Injury R3: Shoulder-Preserving Transfers P4 Neuromuscular Electrical Stimulation (NMES) for Mobility (Lucinda Baker) D4: Stimulated Active Seating for Pressure Ulcer Prevention

5. ICARE Leadership Structure: Administrative Core => DMAC & 3 Regional Centers => Clinical Sites Admin Core (USC): Carolee Winstein, Study PI; Monica Nelsen, Project Mgr. DMAC (USC ) : Christianne Lane, Director; Stanley Azen, Co-Director; Steven Cen, Co-Director of Database. 3 Regional Centers (DC, Atlanta, LA): Alex Dromerick, Co-PI (Wash DC); Steve Wolf, Co-PI (Atlanta). ICARE Team = 97 Active Personnel Wash, DC (NRH) Los Angeles (USC) Atlanta (Emory CRM)

6. Different, yet many commonalities

7. Conferencing Telephone Video & Web (Go-to-Meeting) Web-site Discussion Boards; Wikis Multi-media Training tools Informational materials On-Site/In-Person Other (State of Science; Site Visits) Communication, Communication, Communication

8. Plan vs. Reality

9. Building a strong team

10. Priority vs. Urgency

11. Building a strong team

12. Recognizing the artistry in bioinformatics, biostatistics, and game development Creating a strong Data Management System

13. Educate colleagues (both those who call themselves either “researchers” or “clinicians”) about the valuable role each plays in the collaboration Empower colleagues to become proactively involved in the research enterprise Encourage senior leadership to create positive research experiences during the intellectual mentoring of junior colleagues Dissemination opportunities for our junior collaborators (E3)

14. Summary: Common Lessons Learned • Be proactive and ready to roll once the NOA is received (useful resources, now more than before) • Establish regular schedule for communication • Keys for building a strong and cohesive team • Knowing the difference between priority and urgency • Compromise /negotiate to accommodate plan vs reality • Remain flexible and nimble • Rapid advances in technology (RERC) • Changing healthcare environment (ICARE) • Plan for dissemination from the start (publication policy and procedure)

15. Publications • Winstein C, et al., Reply. JAMA. July 5;316(1):102. Doi: 10.1001/jama.2016.5025. • Winstein CJ, et al., JAMA, Feb 9; 315(6):571-81. Doi: 10.1001/jama.2016.0276. PMID: 26864411 • Lawrence EL, et al., Front Aging Neurosci. Jun 5;7:108. Doi: 10.3389/fnagi.2015.00108. 2015. • Wang X, et al., Comp Biol and Med, http://dx.doi.org/10.1016/j.compbiomed.2015.03.024 • Winstein C, & Requejo P. Phys Ther Mar;95(3):294-8. doi: 10.2522/ptj.2015.95.2.294. PMID: 25734191 • Chen Y-A, et al., 2015. J Motor Learn Dev, 3:91-109. • Duff S, et al., Neurorehab Neural Repair, 2014, Oct 16, pii:1545968314553030. [Epub ahead of print] • Winstein C, et al., J Neurol Phys Ther. 2014 Jul;38(3):190-200. doi: 10.1097/NPT.0000000000000046. • Proffitt R, et al., J Aging Phys Act Dec 11 [Epub ahead of print], published in 2015, 23(1):24-33 • Wade E, et al.. Neurorehabilitation and Neural Repair, 2014,Feb;28(2):169-78. PMID: 24213957 • Winstein CJ, et al., for the ICARE Investigative Team 2013. BMC Neurology 13:5. • Winstein CJ, et al., Frontiers in Psychology, 2012, Sept, 3: Article 340 • Rizzo A, et al., Stud Health Technol Inform. 2011,163:510-6. • Lange B et al., Phys Med Rehabil Clin N Am. 2010, May;21(2):339-56.

16. Q&A