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To study the effect of a poly herbal therapy HUMA in 25 patients suffering from Oral malignancy. S Hina Fatima 1 , N Moorchung 2 and Sanjoy Kumar Pal 3. Huma Cancer Society, Ganj Plaza, Hazratganj, Lucknow UP 226001, India 1
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To study the effect of a poly herbal therapy HUMA in 25 patients suffering from Oral malignancy S Hina Fatima 1, N Moorchung 2 andSanjoy Kumar Pal3 Huma Cancer Society, Ganj Plaza, Hazratganj, Lucknow UP 226001, India1 Department of Pathology 2 and Gastroenterology 3, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow UP 226014, India2
HUMA is an Poly-herbal Alternative Cancer Therapy tried by patients mostly with advanced malignant disease
HUMA Therapy advocated by Some important Ayurvedic herb from which HUMA Therapy evolved Azadirachta indica Acacia catechuAsparagus recemosus Curcuma longa Calotropis procera Catharanthus roseus Embelica officinalis Ocimum sanctum Plumbago xylanicaSemecarpus anacardium Tinospora cordifoliaTiliacora racemosa Withania sominifera Late Dr. S M Atiq [07.04.32 – 01.11.1994]
Drug Toxicities Studies in animal model were done in CDRI, Lucknow
Some Facts about HUMA This poly-herbal preparation do not contain any heavy metals. The medicines are in liquid and powdered form. The medicines are orally administrated and are titrated time to time depending on the condition of the patient. Along with HUMA therapy the patients also receive conventional life support care. Adverse side effects are less because of individualized dosing. Medicines are prepared by the Huma Cancer Society & checked for batch to batch variations. Marked regression of cancer / tumor were observed in some patients suffering from oral and rectal malignancy.
We studied the effect of HUMA in 25 patient with oral malignancy Convention therapy was not offered to 20 patients because of the following problems: Financial problem - 10 (50.0 %) Did not get immediate date for RT - 02 (10.0 %) For Palliation - 03 (15.0 %) Faith in this alternative therapy - 05 (25.0 %) Five patients had earlier received conventional treatment.
Results of HUMA Therapy in oral Cancer patients Complete regression of the tumor / lesion 04 (16 %) Marked remission of the tumor / lesion 08 (32 %) Adverse effects of therapy Nil Completed 5 years disease free survival 01 (04 %) Relapsed after stoppage of therapy 05 (20%) No effect of this therapy 13 (52 %)
Case reports of some patients who responded to this alternative therapy
At Presentation 1 month after therapy 6 months after therapy Clinical Details: Age : 70 Years Histology : Verrucous Carcinoma Stage : T 4 N 3 M x Conventional therapy : Refused because of old age Response to HUMA : ++++ Present status : Stable and Alive Relapse free survival : 6 years One year after therapy
At Presentation 1 month after therapy 6 months after therapy Clinical Details: Age : 58 Years Histology : Sq Cell Carcinoma Stage : T3/4 N1 MX Conventional therapy : Refused because of financial problem Response to HUMA : +++ Relapse free survival : 3 years Present status : Stable & continuing therapy 1 year after therapy 3 year after therapy
6 months after therapy 9 months after therapy At Presentation 3 months after therapy 12 months after therapy 14 months after therapy 18 months after therapy 22 months after therapy
At Presentation 6 months after therapy 6 months after therapy Clinical Details Age : 32 Years Histology : Sq Cell Carcinoma Stage : T 4 N 3 M x Conventional therapy : Nil Response to HUMA : +++ Present status : Dead Survival : 12 months 9 months after therapy
At Presentation 9 months after therapy Clinical Details:Diagnosis: Sq Cell Ca Response: +++ Present Status: Dead Survival : 14 months Histopathology
At Presentation 3 months after therapy 5 months after therapy Histopathology Clinical Details Age 60 Years Histology Sq Cell Carcinoma Stage T 3 N 1 M 0 Conventional therapy Nil Response to HUMA +++ Present status Dead Survival 11 months 8 months after therapy Recurrence of the disease after FNA was done
Histopathology At Presentation 3 months after therapy Clinical Details: Age : 30 Years Histology : Sq Cell Carcinoma Stage : T 4 N 1 M 0 Conventional therapy : Nil Response to HUMA : +++ Present status : Dead Survival : 10 months 6 months after therapy 9 months after therapy
Before therapy 6 months after therapy
Before therapy 3 months after therapy
A patient who did not respond to HUMA therapy. This patient had earlier receive complete cycle of Radiotherapy.
Conclusions: • In absence of conventional cancer therapy the regression of tumor/lesion observed in some patients could be because of the poly-herbal therapy. • No adverse side effects were noticed in any of the patients. • A proper well designed controlled clinical study should be conducted to know the exact efficacy / toxicity of this formulation. • The herbs used in this therapy could provide important lead for new anti-cancer drug discovery programme.
ACKNOWLEDGEMENT Prof. Rajan Saxena Dept. of Gastro Surgery SGPGIMS Prof. G Choudhuri Dept. of Gastroenterology SGPGIMS Prof. Raj Melhotra Dept. of Pathology KGMC Prof. I D Sharma Dept. of Oncosurgery KGMC Dr. M L Bhatt Dept. of Radiotherapy KGMC Dr. A Chandra Dept. of Surgery KGMC Dr. Tauseef Ahmed Nishat Hospital Lucknow Help of all patients and their relatives who have made this study possible