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CONSTITUTIONAL SYMPTOMS

Explore the latest management approaches for various lupus symptoms, including constitutional, cutaneous, articular, hematologic, serositis, vasculitis, glomerulonephritis, and nervous system manifestations. Learn about medications like steroids, antimalarials, immunosuppressants, and more.

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CONSTITUTIONAL SYMPTOMS

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  1. CONSTITUTIONAL SYMPTOMS • Reassurance • Rest/exercise • NSAID • Antimalarials • Steroids (e.g. Prednisone < .25 mg/kg/day) • DHEA • TCA/SSRI/Behavioral or cognitive therapy

  2. CUTANEOUS • Sun avoidance/sunblock • Steroids (topical and intralesional) • Hydroxychloroquine (plaquenil) • Chloroquine (aralen) • Quinacrine (atabrine) • Dapsone • Retinoids (isotretinoin) • Clofazamine • Azathioprine

  3. ARTICULAR • NSAID • Antimalarials (HCQ, CQ) • Methotrexate • Azathioprine • Steroids (e.g. Prednisone < .25 mg/kg/day)

  4. HEMATOLOGIC (AIHA/AITP) • Steroids (e.g. Prednisone 1 mg/kg/day; Decadron 40 mg day x 4 days) • Danazol • Dapsone • Vincristine • Cyclophosphamide • Intravenous immunoglobulin (IVIG) • Splenectomy • CSF (Epogen, Neupogen)

  5. SEROSITIS • NSAID (e.g. Indomethacin) • Antimalarials (HCQ, CQ) • Steroids (e.g. Prednisone < .5 mg/kg/day) • Aspiration

  6. VASCULITIS • Steroids (e.g. Prednisone 1 mg/kg/day) • Cyclophosphamide • Plasmapherisis (especially TTP/TMHA) • Intravenous immunoglobulin (IVIG)

  7. Current Management of Lupus Glomerulonephritis Steroids oral daily or QOD Pulse solumedrol Cyclophosphamide Azathioprine Cyclosporine Methotrexate Plasmapheresis  synchronized Intravenous gammaglobulin Mycophenolate mofetil 2 chlorodeoxyadenosine Fludarabine Recombinant human DNAse NSAID ACE inhibitors Low protein diet

  8. NERVOUS SYSTEM • Steroids (e.g. Prednisone 1 mg/kg/day) • Cyclophosphamide • IVIG • Psychotropics (e.g. Haloperidol) • TCA/SSRI

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