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The pharmaceutical R&D process

10-12 years, costly ($30 Mn – $1300Mn). The pharmaceutical R&D process. Risks in research and development of pharmaceutical drugs. (Preziosi, P. 2004, Nature Reviews in Drug Discovery 3, 521-526). The pharmaceutical R&D process many different ways to innovate.

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The pharmaceutical R&D process

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  1. 10-12 years, costly ($30 Mn – $1300Mn) The pharmaceutical R&D process

  2. Risks in research and development of pharmaceutical drugs (Preziosi, P. 2004, Nature Reviews in Drug Discovery 3, 521-526)

  3. The pharmaceutical R&D processmany different ways to innovate • Innovation in discovery: identifying new molecules, new drug candidates • - Basic research to understand critical pathways that can be blocked • - Development of test systems to model these pathways • - Screening of large number of molecules (=libraries) to identify « hits » • - Hit-to-lead characterisation and selection: druggability • - Lead-optimisation: more potent, better absorbed, less toxic,

  4. The pharmaceutical R&D processmany different ways to innovate • new or better uses of existing molecules / treatments

  5. Compound mining:creative utilization of existing knowledge Nitroimidazoles: rediscovered drug candidates for protozoal diseases Extensive literature / patent review, including personal consultations with researchers (previously) active on this class of compounds to uncover possible compounds of interest >600 compounds identified from >15 sources; assessed in in vitro / in vivo disease models; several series with promising activity identified 1 new drug candidate in clinical development for sleeping sickness: fexinidazole (off-patent):

  6. The pharmaceutical R&D processmany different ways to innovate

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