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Host-Parasite Relationship

Host-Parasite Relationship. Normal Flora Pathogens Infections Opportunistic pathogens. Skin Flora. 180 species Streptococcus Staphylococcus Propionibacterium Body Odor Acne. Oral Cavity Flora. Plaque Anaerobes Biofilms Dental Caries Streptococcus mutans, sobrinus Sucrose.

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Host-Parasite Relationship

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  1. Host-Parasite Relationship • Normal Flora • Pathogens • Infections • Opportunistic • pathogens

  2. Skin Flora • 180 species • Streptococcus • Staphylococcus • Propionibacterium • Body Odor • Acne

  3. Oral Cavity Flora • Plaque • Anaerobes • Biofilms • Dental Caries • Streptococcus mutans, sobrinus • Sucrose

  4. Tongue

  5. Intestinal Tract Stomach – pH Helicobacter pylori • Small Intestine • Enterococci, • Lactobacilli

  6. Large intestine • 1010-1011 cells/gm • Bacteroides • Enterobacteria • Escherichia coli • Enterococcus

  7. Large Intestine Flora • Methanogens • Food passage 24 hrs • Excrete 1013/day • Probiotics • Fecal transplant

  8. Respiratory Tract • Staphylococcus aureus • Streptococcus pneumoniae • S. pyogenes • Corynebacterium diphtheriae • Carrier

  9. Urogenital Tract Opportunistic Pathogens E. coli Virulence Invasiveness Toxicity Lactobacillus acidophilus

  10. Adherence • Specific Adherence • Capsule • Slime Layer • Glycocalyx • Fimbriae • Pili - longer

  11. Invasiveness • Colonization Factor Antigen • Invasion • Colonization • Iron- Siderophore • Bacteremia vs. Septicemia

  12. Enzymes & Toxins • Coagulase • Collagenase • Exotoxins • Cytolytic Toxins • Hemolysins, Leukocidins • Diphtheria Toxin • Botulism Toxin • Tetanus Toxin Tetanus

  13. Other Toxins Enterotoxin Cholera toxin Endotoxin – Pyrogen LD50 Virulence Factors Attenuated Strains Pyrogen free Products

  14. Virulence Factors

  15. Nonspecific Host Defense • Natural Resistance • Age • Stress • Diet • Anatomical Defenses • Skin, Stomach, Tears

  16. Compromised Hosts Inflammation Fever Nosocomial Infections

  17. Host-Parasite Word List Stomach – pH2 Helicobacter pylori Small Intestine Enterococci, Lactobacilli Large Intestine 1010- 1011 cells/gram Normal Flora Pathogens Infection Skin Flora Staphylococcus, Propionibacterium Oral Cavity Flora Plaque Streptococcus spp Dental Caries Streptococcus mutans Intestinal Tract

  18. Host-Parasite Word List 2 1010- 1011 cells/gram Bacteroides, Enterobacteria, Escherichia coli, Enterococcus Respiratory Tract Staphylococcus aureus, Streptococcus pneumoniae, S. pyogenes,Corynebacterium diphtheriae Carrier Urogenital Tract Opportunistic Pathogens Virulence Invasiveness, Toxicity Specific Adherence

  19. Host-Parasite Word List 3 Capsule, Glycocalyx, Slime Layer Fimbriae, Pili Colonization Factor Antigen Enzymes & Toxins Coagulase, Collagenase Exotoxins Cytolytic Toxins Hemolysins, Leukocidins Invasion Colonization Iron – Siderophore Bacteremia – Septicemia

  20. Host-Parasite Word List 4 Endotoxin LD50 Attenuated Nonspecific Host Defenses Natural Resistance Natural Resistance Age, Stress, Diet Anatomical Defenses Skin, Stomach, Tears Diphtheria Toxin Botulism Toxin Tetanus Toxin Enterotoxin Cholera Toxin

  21. Host-Parasite Word List 5 Compromised Host Inflammation Fever

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