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Main Findings:

Francesca Lemme 1,2 , Aoife Doyle 1,2 , John Changalucha 3 , Helen Weiss 1 , Kathy Baisley 1 , Kaballa Maganja 2 , Deborah Watson-Jones 1,2 , Saidi Kapiga 1,2 , Richard Hayes 1 , David Ross 1 1 London School of Hygiene & Tropical Medicine, London, UK

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Main Findings:

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  1. Francesca Lemme1,2, Aoife Doyle1,2, John Changalucha3, Helen Weiss1, Kathy Baisley1, Kaballa Maganja2, Deborah Watson-Jones1,2, Saidi Kapiga1,2, Richard Hayes1, David Ross1 1London School of Hygiene & Tropical Medicine, London, UK 2Mwanza Intervention Trials Unit, Mwanza, Tanzania 3National Institute for Medical Research, Mwanza, Tanzania HIV infection among young people in northwest Tanzania:the role of biological, behavioural and socio-demographic risk factors • 1998-2008: randomised controlled trial of MEMA kwaVijana adolescent sexual & reproductive health intervention – SRH education, youth friendly clinic services etc. • 20 rural communities randomised to intervention (10) and control (10) arms • Long-term evaluation survey conducted in 2007-8 among young people (15-30y) to assess impact of intervention on biological & behavioural outcomes. • HIV and HSV-2 prevalence • 1.8% and 25.8% in males • 4.1% and 41.4% in females • No impact of intervention on primary outcomes: HIV & HSV2 prevalence. • Risk factors for HIV determined using a proximate-determinants conceptual framework & logistic regression conditional on community

  2. Main Findings: OR of HIV infection for selected socio-demographic, behavioural and biological factors in 6476 female & 7259 male participants

  3. Important implications • HIV prevalence was higher in young women than young men; HSV-2 prevalence was high in both sexes • HIV prevalence was associated with biological (HSV2, GUD), behavioural (number of sexual partners) and socio-demographic (age, marital status, travel from home) factors • Control of GUD, HSV2 and other STIs and effective behavioural interventions are urgently needed to reduce further spread of HIV in this population • A special focus on mobile young people, and those who are separated, widowed or divorced may be warranted.

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