1 / 21

Amino Acids, Peptides and Proteins

Amino Acids, Peptides and Proteins. Chapter 23. Amino Acids, Peptides and Proteins. 1. Answer the following: a. Which amino acid(s) is achiral? b. Are naturally occurring amino acids D or L? c. Which amino acids(s) have 2 chiral centers?. Amino Acids, Peptides and Proteins.

brygid
Download Presentation

Amino Acids, Peptides and Proteins

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Amino Acids, Peptides and Proteins Chapter 23

  2. Amino Acids, Peptides and Proteins 1. Answer the following: a. Which amino acid(s) is achiral? b. Are naturally occurring amino acids D or L? c. Which amino acids(s) have 2 chiral centers?

  3. Amino Acids, Peptides and Proteins 2. Explain kinetic resolution.

  4. Amino Acids, Peptides and Proteins 3. Draw the following amino acids at pH = 0, 5, and 13. a. Valine b. Glutamate c. Lysine

  5. Amino Acids, Peptides and Proteins 4. Calculate the pI of the following amino acids. a. Phenylalanine b. Histidine c. Aspartic Acid

  6. Amino Acids, Peptides and Proteins 5. What is the net charge of the following amino acids at the designated pHs? a. Serine at pH = 4 b. Arginine at pH = 5 c. Glutamic acid at pH = 5

  7. Amino Acids, Peptides and Proteins 6. Which amino acids are the most polar and nonpolar?

  8. Amino Acids, Peptides and Proteins 7. Thin layer chromatography of a solution of threonine, valine, lysine, alanine and serine yielded the following; determine which amino acid goes with each spot?

  9. Amino Acids, Peptides and Proteins 8. Gel electrophoresis of a solution of histidine, tyrosine, lysine, aspartate and glutamic acid yielded the following determine which amino acid goes with each spot? cathode anode

  10. Amino Acids, Peptides and Proteins 9. Show how alanine can be synthesized via… a. HVZ b. Reductive amination c. N-Phthalimidomalonic ester synthesis d. Strecker Sythesis

  11. Amino Acids, Peptides and Proteins 10. Draw the met-ile-tyr-asn-his at pH = 7

  12. Amino Acids, Peptides and Proteins 11. Show how the following peptide can be synthesized ala-gly-ser

  13. Amino Acids, Peptides and Proteins 12. Distinguish between primary, secondary, tertiary and quaternary structures of peptides and proteins.

  14. Amino Acids, Peptides and Proteins 13. Descibe denaturation and give examples of possible causes for denaturation.

  15. Amino Acids, Peptides and Proteins 14. Show the cleavage sites on the following peptide if introduced to each of the following reagents: ala-gly-phe-met-ser-lys-tyr-asn-glu-arg-pro-met-leu-his A. Carboxypeptidase A B. Edmans C. Cyanogen bromide D. Trypsin E. Chymotrypsin

  16. Amino Acids, Peptides and Proteins

  17. Amino Acids, Peptides and Proteins

  18. Amino Acids, Peptides and Proteins

  19. Amino Acids, Peptides and Proteins

  20. Amino Acids, Peptides and Proteins

  21. Amino Acids, Peptides and Proteins

More Related