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SKELETAL MUSCLE RELAXANTS

SKELETAL MUSCLE RELAXANTS. PERIPHERALLY ACTING Non Depolarizing Neuromuscular Blockers Isoquinoline Derivatives d-Tubocurarine Kidney 40% > 35 Atracurium Spontaneous 20-35 Cisatracurium Mostly spontaneous 25- 44 Doxacurium Kidney > 35

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SKELETAL MUSCLE RELAXANTS

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  1. SKELETAL MUSCLE RELAXANTS

  2. PERIPHERALLY ACTING Non Depolarizing Neuromuscular Blockers Isoquinoline Derivatives d-Tubocurarine Kidney 40% > 35 Atracurium Spontaneous 20-35 Cisatracurium Mostly spontaneous 25- 44 Doxacurium Kidney > 35 Mivacurium Plasma ChE2 10-20 Metocurium Kidney 40% >35 Misc Gallamine

  3. Steroid Derivatives Pancuronium Kidney 80% >35 Pipecuronium Kidney 60% >35 Rocuronium Liver 90% 20 – 35 Vecuronium Liver 90% 20 – 35 Depolarizing Neuromuscular Blockers Suxamethonium Suxethonium Decamethonium

  4. CENTRALLY ACTING Benzodiazepines Diazepam, clonazepam, Nitrazepam GABA Analogues Baclofen Progabide Propanediol Derivatives Mephenesin Meprobamate

  5. Misc Compounds Cyclobenzaprine Methocarbamol Orphenadrine Chlomezanone Tizanidine DIRECTLY ACTING Dantrolene

  6. NON DEPOLARIZING SKELETAL MUSCLE RELAXANTS CHEMISTRY PHARMACOKINETICS MECHANISM OF ACTION

  7. THERAPEUTIC USES 1) ENDOTRACHEAL INTUBATION – ROCURONIUM 2) SURGICAL RELAXATION – BALANCED ANESTHESIA 3) CONTROL OF VENTILATION 4) CONVULSIONS – RARE SIDE – EFFECTS 1) BROCHOSPASM 2) URTICARIA 3) HYPOTENSION

  8. DEPOLARIZING NMJ BLOCKERS CHEMISTRY PHARMACOKINETICS MECHANISM OF ACTION PHASE – I BLOCK PHASE – II BLOCK PHARMACOLOGICAL ACTIONS SKELETAL MUSCLES CVS

  9. SIDE – EFFECTS 1) HYPERKALEMIA 2) RAISED INTRA – OCCULAR AND INTRA – GASTRIC PRESSURES 3) MUSCLE PAIN 4) MALIGNANT HYPERTHERMIA 5) PROLONGED APNOEA THERAPEUTIC USES 1) ENDOTRACHEAL INTUBATION

  10. CENTALLY ACTING SKELETAL MUSCLE RELAXANTS DIAZEPAM BACLOFEN TIZANIDINE DIRECTLY ACTING SKELETAL MUSCLE RELAXANT DANTROLENE

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