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Immunization Update 2007 Satellite Broadcast/Webcast August 9, 2007 Rotavirus Vaccine Segment

Immunization Update 2007 Satellite Broadcast/Webcast August 9, 2007 Rotavirus Vaccine Segment. Graphics subject to change. This material in the public domain. Burden of Rotavirus Disease in the United States. 3 million infections every year More than 400,000 physician visits

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Immunization Update 2007 Satellite Broadcast/Webcast August 9, 2007 Rotavirus Vaccine Segment

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  1. Immunization Update 2007 Satellite Broadcast/Webcast August 9, 2007 Rotavirus Vaccine Segment Graphics subject to change. This material in the public domain.

  2. Burden of Rotavirus Disease in the United States • 3 million infections every year • More than 400,000 physician visits • 200,000 emergency dept visits • 55,000-70,000 hospitalizations • 20- 60 deaths Source: MMWR 2006;55 (RR-12)

  3. Rotavirus Vaccines • Created by genetic reassortment • causes nonhuman rotavirus strains to express human rotavirus antigens on their surface • nonhuman rotaviruses have low pathogenicity for humans • replicate but do not cause disease

  4. Rotashield and Intussusception • Significantly increased risk of intussusception among infants who received Rotashield • Highest risk was observed 3-7 days after the first dose • Resulted in the vaccine being taken off the market in late 1999

  5. Rotavirus Vaccine and Intussusception Vaccine Recipients 6 cases 13 cases Placebo Recipients 5 cases 15 cases Within 42 days of vaccination Within 1 year of vaccination Source: New Eng J Med 2006;354:23-33

  6. RotaTeq Intussusception ReportsReceived by VAERS* • 117 confirmed reports • 38 cases 1-21 days after vaccination • 23 cases 1-7 days after vaccination • about one third of 38 cases occurred following the first dose • 6 million vaccine doses distributed *March 2006 through mid-June 2007

  7. Expected and Reported Cases of Intussusception After RotaTeq *Among children 6-35 weeks of age, within 21 days of a dose based on VSD data

  8. Rotavirus Vaccine Recommendations • 3 oral doses at 2, 4, and 6 months of age • Series may be started as early as 6 weeks of age • First dose should be administered between 6 and 12 weeks of age • Vaccination should NOT be initiated for infants older than 12 weeks of age • Minimum interval between subsequent doses is 4 weeks Source: MMWR 2006;55 (RR-12)

  9. Rotavirus Vaccine Recommendations • All 3 doses of vaccine should be administered by 32 weeks of age • Vaccine should NOT be administered after 32 weeks of age Source: MMWR 2006;55 (RR-12)

  10. CDC Vaccines and ImmunizationContact Information • Hotline (800) CDC-INFO • Email nipinfo@cdc.gov • Website www.cdc.gov/nip • Broadcast Updates and Resources Web Page www.cdc.gov/vaccines/ed/broadcasts.htm

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