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3. 24/02/2018 Buy Lopimune Tablets | AllDayGeneric.com - My Online Generic Store Buy Lopimune (Lopinavir 20mg + Ritonavir 50mg) online, Lopinavir and ritonavir are an?viral medica?ons that prevent human immunodeficiency virus (HIV) cells from mul?plying in your body. Lopinavir and ritonavir (Lopimune) is a combina?on medicine used to treat HIV…. Pack Size Price Quan?ty 60 Tablet/s $72.00 ADD TO CART 1 120 Tablet/s $132.00 ADD TO CART 1 180 Tablet/s $192.00 ADD TO CART 1  Compare (/Product/Lopimune-Tablets/?Ac?on=Yith-Woocompare-Add-Product&Id=5611)  Add To Wishlist (/Product/Lopimune-Tablets/?Add_to_wishlist=5611) (h?ps://www.mcafeesecure.com/verify?host=alldaygeneric.com)      DESCRIPTION ADDITIONAL INFORMATION REVIEWS (5) Lopimune Tablets (h?ps://alldaygeneric.com) Composition Each film-coated tablet contains • Lopinavir…..200 mg • Ritonavir…..50 mg Indication Lopimune tablets contains Lopinavir 200mg + Ritonavir 50mg, it is a fixed dose combina?on treatment for Human Immunodeficiency Virus (HIV) infec?on in adults over and children over 6 months. Lopimune tablets Lopinavir 200mg + Ritonavir 50mg are used in combina?on with other medica?ons that have a different mechanism of ac?on to the components in Lopimune, and are used to treat pa?ents with HIV infec?on who have either already received treatment with other medica?ons for HIV or as first line therapy for treatment-inexperienced pa?ents. https://www.alldaygeneric.com/product/lopimune-tablets/ 3/9

4. 24/02/2018 Buy Lopimune Tablets | AllDayGeneric.com - My Online Generic Store How does Lopimune work? Lopimune tablets Lopinavir 200mg + Ritonavir 50mg contain lopinavir and ritonavir, which are both inhibitors of HIV protease and are only effec?ve against RNA viruses (retroviruses) like Human Immunodeficiency Virus (HIV). Retroviruses convert RNA to DNA, by the ac?on of the viral-specific enzyme reverse transcriptase (RT). The viral DNA is then integrated into the DNA of infected immune cells so that the virus can replicate. Most of the an?viral ac?vity of Lopimune is due to lopinavir, which is a potent inhibitor of HIV protease, and prevents cleavage of the Gag-Pol polyprotein, an important protein in the development of ac?ve virus. The viral protease enzyme cleaves (breaks down) the Gag-Pol polyprotein during final stages of the replica?on cycle so that fully ac?ve mature virus can be released to infect new cells. Inhibi?on of protease cleavage by Lopimune results in the produc?on of immature, non-infec?ous viral par?cles. Ritonavir in Lopimune tablets Lopinavir 200mg + Ritonavir 50mg is included in the combina?on not as a protease inhibitor but because it inhibits the CYP3A-mediated metabolism (breakdown in the liver) of lopinavir, thereby increasing the plasma levels of lopinavir so that lopinavir can be used at a lower dose. Lopimune tablets are used in combina?on with other retrovirals that have a different mechanism of ac?on, like emtricitabine and tenofovir, both nucleoside reverse transcriptase inhibitor (NRTI) that work by blocking the ac?on of RT, inhibi?ng viral replica?on. The combined ac?on of lopinavir and ritonavir in Lopimune tablets Lopinavir 200mg + Ritonavir 50mg, in conjunc?on with other retroviral drugs, inhibits the produc?on of ac?ve HIV so that the viral load (amount of virus) is reduced. Lopimune tablets slow down the replica?on of HIV within your body but does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infec?on to others. How to Use Lopinavir and Ritonavir Tablets? You should stay under a doctor’s care when taking Lopinavir and Ritonavir tablets. Do not change your treatment or stop treatment without first talking with your doctor. Take this medicine with food to help it work be?er. You must take Lopimune tablets every day exactly as your doctor prescribed it. The dose of this medicine may be different for you than for other pa?ents. Be sure to set up a schedule and follow it carefully. When your supply starts to run low, get more from your doctor or pharmacy. This is very important because the amount of virus in your blood may increase if the medicine is stopped for even a short ?me. The virus may develop resistance to this medicine and become harder to treat. Only take medicine that has been prescribed specifically for you. Do not give this medicine to others or take medicine prescribed for someone else. It is important that you do not miss any doses. If you miss a dose of this medicine, take it as soon as possible and then take your next scheduled dose at its regular ?me. If it is almost ?me for your next dose, do not take the missed dose. Wait and take the next dose at the regular ?me. Do not double the next dose. What are the side effects of Lopimune? https://www.alldaygeneric.com/product/lopimune-tablets/ 4/9

5. 24/02/2018 Buy Lopimune Tablets | AllDayGeneric.com - My Online Generic Store The most commonly reported side effects when taking Lopimune tablets Lopinavir 200mg + Ritonavir 50mg include: mild to moderate diarrhoea; increased blood cholesterol and triglycerides, which may be a risk factor for pancrea??s; increased liver enzymes such as gamma-glutamyltransferase (GGT); redistribu?on of body fat from the arms, legs and face to the abdominal region; inflamma?on reac?on due to immune recons?tu?on syndrome as the immune system recovers and fights infec?on caused by residual infec?on. Contraindication • LOPIMUNE is contraindicated in pa?ents with previously demonstrated clinically significant hypersensi?vity (e.g. toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema mul?forme, ur?caria, angioedema) to any of its ingredients, including ritonavir. • Co-administra?on of LOPIMUNE is contraindicated with drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentra?ons are associated with serious and/or life-threatening reac?ons. • Co-administra?on of LOPIMUNE is contraindicated with potent CYP3A inducers where significantly reduced lopinavir plasma concentra?ons may be associated with the poten?al for loss of virologic response and possible resistance and cross-resistance. Missed dose of Lopimune If you miss a dose of Lopimune tablets Lopinavir 200mg + Ritonavir 50mg take it as soon as you remember, unless it is ?me to take the next dose, then skip the missed dose. Do not take a double dose. How should Lopimune be stored? You should store your Lopimune tablets Lopinavir 200mg + Ritonavir 50mg below 30°C in a cool dry place. EXPERT ADVICE • Consult your doctor about taking the ritonavir if you had a history of hepa??s A or B, hemophilia, diabetes, erec?le dysfunc?on, kidney disease, any kind of infec?on, s?ffness or aches or pains in joints, weakness or pain or tenderness in muscles, light-headedness, dizziness, fain?ng episodes or abnormal heartbeat. • Ritonavir tablets should always be taken with food. • Use effec?ve methods of contracep?on to avoid pregnancy. • Do not drive or operate machinery as ritonavir can cause dizziness or sleepiness. FREQUENTLY ASKED QUESTIONS Ritonavir Q. Is ritonavir safe during pregnancy? Ritonavir can be taken during pregnancy if the benefit outweighs the risk. https://www.alldaygeneric.com/product/lopimune-tablets/ 5/9

6. 24/02/2018 Buy Lopimune Tablets | AllDayGeneric.com - My Online Generic Store Q. Is ritonavir safe during breas?eeding? Ritonavir is not safe for the baby and should not be used by women who are breas?eeding. HIV infected women should not breast-feed as the virus can pass on to the baby from breast milk. Q. Is ritonavir a protease inhibitor? What is ritonavir used for? Ritonavir, a protease inhibitor, is used along with other medica?on for trea?ng human immunodeficiency virus (HIV) infec?on. It does not completely cure HIV or AIDS. Lopinavir Q. Is Lopinavir safe during pregnancy? Lopinavir should only be used if the poten?al benefits jus?fy the poten?al risk to the baby. Please follow your doctor’s advice regarding its use. Q. Is Lopinavir safe during breas?eeding? Lopinavir should be given only if the poten?al benefit jus?fies the poten?al risk to the infant. Please follow your doctor’s advice regarding its use. Q. Is Lopinavir safe? Lopinavir is safe if used at prescribed doses for the prescribed dura?on as advised by your doctor. Related Products (h?ps://www.alldaygeneric.com/product/ocuvir- 200-dt/) (h?ps://www.alldaygeneric.com/product/acivir- 400-dt/) (h?ps://www.alldaygeneric.com/prod hbv-100mg/) Ocuvir 200 DT (H?ps://Www.Alldaygeneric.Com/Product/Ocuvir- 200-Dt/) Acivir 400 DT (H?ps://Www.Alldaygeneric.Com/Product/Acivir- 400-Dt/) Lamivir HBV 100mg (H?ps://Www.Alldaygeneric Hbv-100mg/) Generic Name : Acyclovir Generic for : Zovirax Generic Name : Acyclovir Generic for : Zovirax Generic Name : Lamivudine Generic for : Epivir https://www.alldaygeneric.com/product/lopimune-tablets/ 6/9

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