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ADVANCED PARTNERSHIP PLATFORM FOR EARLY DRUG DISCOVERY

Fully Integrated Resources For Drug Discovery. HTS Compounds, Pre-plated Diversity Sets, Fragment Libraries, Contract Research Services & more.

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ADVANCED PARTNERSHIP PLATFORM FOR EARLY DRUG DISCOVERY

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  1. ADVANCED PARTNERSHIP PLATFORM FOR EARLY DRUG DISCOVERY

  2. FRAMEWORK OF PRODUCTS AND SERVICES Fully Integrated Resources For Drug Discovery HTS Compounds HTS compound collection Pre-plated diversity sets Fragment Libraries Targeted & Focused Libraries Contract research services Custom Synthesis Computational Chemistry GLP Primary Drug Trials – Key Preclinicals Fine Chemicals in Multigram Scale Advanced Building Blocks IR-Dyes APIs Fine Reagents for Organic Synthesis Scale-up Synthesis (up to 100kg) Process Optimization Off-the-shelf Building Blocks Tangible Building Blocks Cutting-edge Design of Building Blocks Custom Synthesis of Building Blocks and Intermediates

  3. ADVANCED BUILDING BLOCKSFOR LIFE AND MATERIALS SCIENCES There are about 50,000 structures, based on rare chemotypes in our collection. Most of the compounds are not commonlyavailable: more than 50 % of the database have < 5 suppliers in ACD There are more than 12,000 building blocks in stock. High quality standards: over 95 % purity confirmed with NMR and/or LCMS Physicochemical properties favorable for lead-oriented synthesis Building blocks of interest for many areas of natural sciences: pharmaceutical, agrochemical, materials sciences. You can see availability and prices immediately at https://shop.lifechemicals.com/ Quality and Handling standards: Over 90 % purity, confirmed by LCMS and/or 400MHz NMR Prompt delivery in any container Bar-coding and labeling according to customers’ requirements

  4. ADVANCED BUILDING BLOCKSFOR LIFE AND MATERIALS SCIENCES

  5. ADVANCED BUILDING BLOCKSFOR LIFE AND MATERIALS SCIENCES Lead oriented 11.9 1.17 2.2 0.52

  6. ADVANCED BUILDING BLOCKS FOR LIFE AND MATERIALS SCIENCES Primary amines:

  7. ADVANCED BUILDING BLOCKS FOR LIFE AND MATERIALS SCIENCES Secondary amines:

  8. ADVANCED BUILDING BLOCKS FOR LIFE AND MATERIALS SCIENCES Carboxylic acids:

  9. ADVANCED BUILDING BLOCKS FOR LIFE AND MATERIALS SCIENCES Alkylation agents:

  10. ADVANCED BUILDING BLOCKS FOR LIFE AND MATERIALS SCIENCES Sulfonyl chlorides:

  11. ADVANCED BUILDING BLOCKS FOR LIFE AND MATERIALS SCIENCES Organofluorine compounds:

  12. ADVANCED BUILDING BLOCKS FOR LIFE AND MATERIALS SCIENCES Special reagent classes: Trifluoroborates Alkyl hydrazines Epoxides

  13. ADVANCED BUILDING BLOCKS FOR LIFE AND MATERIALS SCIENCES Special reagent classes: Bicyclic diamines Bicyclic amino acids

  14. ADVANCED BUILDING BLOCKS FOR LIFE AND MATERIALS SCIENCES Examples of stock available building blocks:

  15. FINE REAGENTS IN MULTIGRAM SCALE Life Chemicals offers • Multi-kg synthesis of rare reagents for organic synthesis (25L, 50L and 75 L reactors are available) • Scale-up of procedures from mg/g to kg quantities • Compounds for materials sciences: dyes, extragents, calixarenes, monomers, ligands, etc. • Proprietary catalogue of functional dyes and fine reagents in multigram scale • GMP synthesis in terms of subcontracting agreements

  16. LIFE CHEMICALS GEOGRAPHY Total number of employees: Over 110, including 61 chemists (1 Prof, 11 PhDs, 35 MSc, 14 BSc) Production space: 2,500 m2

  17. ORDER HANDLING Life Chemicals guarantees high quality service and flexibility Inquiry: quotation within 0-3 business days Order: the process is launched immediately after the order Synthesis (for non-stock compounds): normally 2-6 weeks, progress reports are provided upon request Quality control: high quality standards (purity of 90 – 95 % confirmed with NMR and/or LCMS) Delivery: 3-7 days by FedEx to any destination (customer’s FedEx account can be used) Payment: by cheque, credit card or wire transfer to the account in Germany or in Canada, payment terms are NET 30 days. For small stock orders you can go directly to our shop at https://shop.lifechemicals.com/ Inquiry Order Synthesis QC Delivery Payment

  18. QUALITY ASSURANCE AND ORDER PROCESSING Structure of compounds is validated by analytical data,400 MHz NMR and/or LCMS analysis. Analytical data is readily available upon the customer’s request ISIS .db or .sdf files are enclosed with every shipment Sample weights: 1 mg - 0.5 g with 0.1 mg weighing precision, mg, micromole amounts Compounds forms:- dry powders- frozen DMSO solutions Formatting:- Standard 4mL, 15mm*45mm, amber borosilicate glass vials withrubber-lined plastic screw caps- 96 well PP-masterblocks, Greiner bio-one ref: 780215, U-bottom 1.0ml- 96 well plates, Matrix cat.# 4247, racked round-bottom tubes, 1,4 ml Each plate/box of vials is barcoded and labeled to meet the customer’s requirements

  19. WHY LIFE CHEMICALS? The Company has strong and recognized position in organic synthesis and medicinal chemistry. Novel chemistry and highest quality Our product catalogue includes over 460,000 screening compounds and 12,000 in-house synthesized building blocks Hit resupply Experienced project management Experience in creating of discovery products (targeted libraries, FBDD) Developed platform (analytic labs, logistics, etc.) Access to literature (Reaxys, SciFinder, DiscoveryGate) Chemical Informatics support Our chemists can tackle tasks of highest complexity We work as a fully integrated platform to offer best products and services.

  20. NEW PATENT FREE SCAFFOLDS • Novelty checked in - e-molecules - SciFinder • Average values: - MW 184 - ClogP–0.14 • Enough room for lead-oriented library design, even if rigorous MW/ClogPlimitations are applied Inquiry Quotation Validation Optimization Decoration

  21. LIFE CHEMICALS FACILITIES Renovated building – 2000m2 space Some Facts on our Resources: Up to 50 synthetic chemists can be involved Up to 1000m2 production facilities are available Over 20 years’ experience in parallel synthesis, library design and medicinal chemistry Purification techniques: - TLC, NP LC (CombiFlash) - RP HPLC (Shimadzu)

  22. SYNTHESIS FACILITIES Chemistry labs are supplied with high-end equipment for organic synthesis: Biotage Microwave station Paar autoclaves Photochemistry lab Specialized facility for handling highly toxic reagents

  23. PREPARATIVE CHROMATOGRAPHY LAB CombiFlashRf (SiO2 phase) devices Shimadzu HPLC machines (direct phase and reverse phase columns): semi-preparative scale 0.5g/run Preparative Thin Layer Chromatography

  24. ANALYTICAL LAB Certified by ISO/IEC 17025:2005 NMR lab Capacity: 200 1H NMR spectra daily Varian Gemini 2000 400 MHz with an Oxford Instruments superconducting magnet Varian VXR-300 300 MHz Varian Gemini 200 MHz Ready for 1H, 13C, 19F, 29Si, 31P measurements and advanced 2D NMR techniques (COSY, NOESY, HMQC, HSQC, INADEQUATE) LCMS lab Capacity: 200 samples per day Agilent 1100 Agilent 1200 over 10 columns of various types GCMS Agilent 7820A GC/MSD

  25. ANALYTICAL LAB Certified by ISO/IEC 17025:2005 Water determination by Karl Fischer Titration Qualitative and quantitative determination of functional groups in organic compounds Qualitative and quantitative determination of salt form of organic compounds QC control of solvents and inorganic compounds Measuring Optical Activity (POLAX – 2L, ATAGO polarimeter) Melting Point verification OptiMelt  MPA100 Titroline KF SCHOTT Instruments

  26. X-RAY DIFFRACTOMETER Bruker SMART APEX II 2 Enraf-Nonius CAD-4 four-circle diffractometers

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