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DNA Replication

DNA Replication. DNA Replication Video. Replication Facts. DNA has to be copied before a cell divides DNA is copied during the S or synthesis phase of interphase New cells will need identical DNA strands. 3’. Parental DNA Molecule. 5’. Replication Fork. 3’. 5’.

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DNA Replication

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  1. DNA Replication

  2. DNA Replication Video

  3. Replication Facts • DNA has to be copied before a cell divides • DNA is copied during the S or synthesis phase of interphase • New cells will need identical DNA strands

  4. 3’ Parental DNA Molecule 5’ Replication Fork 3’ 5’ First Steps of Replication • Begins at Origins of Replication • Two strands open forming Replication Forks (Y-shaped region) • New strands grow at the forks

  5. Separating DNA • Enzyme Helicase unwinds and separates the 2 DNA strands by breaking the weak hydrogen bonds • Single-Strand Binding Proteinsattach and keep the 2 DNA strands separated and untwisted

  6. Adding on Nucleotides • Before new DNA strands can form, there must be RNA primers present to start the addition of new nucleotides • Primase is the enzyme that synthesizes the RNA Primer • DNA polymerase can then add on freely floating new nucleotides

  7. Proofreading New DNA • DNA polymerase initially makes about 1 in 10,000 base pairing errors • Enzymes proofread and correct these mistakes • The new error rate for DNA that has been proofread is 1 in 1 billion base pairing errors

  8. Semiconservative Model of Replication • Idea presented by Watson & Crick • The two strands of the parental molecule separate, and each acts as a template for a new complementary strand • New DNA consists of 1 PARENTAL (original) and 1 NEW strand of DNA

  9. DNA Damage & Repair • Chemicals & ultraviolet radiation damage the DNA in our body cells • Cells must continuously repair DAMAGED DNA • DNA ligase and DNA polymerase replace and bond the new nucleotides together

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