Multi-scale Modeling of Failure in Cortical Bone

1. Multi-scale Modeling of Failure in Cortical Bone Elisa Budyn, Mechanical Engineering Primary Grant Support: UIC; Collaboration: EcoleCentrale Paris (Thierry Hoc, Material Science) • Determination of the effects of the local geometrical and material heterogeneities in sane and pathological cortical bone at the micro and nano scales over the local strain and stress fields and global response of the unit cells. • A better understanding of the effect of pathologies over cortical bone quality • Determination of the RVE • Determination of the Macroscopic Moduli • Effect of the cement lines over the local strain field and the work of separation due to crack propagation • Determination of localization patterns • Crack initiation and crack propagation in cortical bone • Multi-scale numerical models to characterize the mechanics of materials and biomaterials with multi-phase complex microstructures. • Failure mechanics of these microstructures though damage and fracture processes studied over the micro and nano scales, modeled through FEM and X-FEM approaches. • Concomitant experiments over the multiple scales.