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Neurons are the basic components of the central and peripheral nervous systems. They play an important role in transmitting information between different areas of the brain, and between the brain and the rest of the nervous system.<br>https://neuros.creative-biolabs.com/category-neural-antibodies-44.htm
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Neural Antibodies TEL: 1-631-357-2254 E-mail: info@creative-biolabs.com SUITE 203, 17 Ramsey Road, Shirley, NY 11967, USA https://neuros.creative-biolabs.com
Cutting Edge Tools for Neuroscience Research Cutting Edge Tools for Neuroscience Research In 2005, Creative Biolabs opened its doors offering neuroscience research antibodies with the goal of putting customers first. From day one, our vision has been to provide products you can trust. We stand behind our products—leading us to create our policy of replacing or refunding reagents or cells that do not meet expectations. As our number of loyal and satisfied customers grow, so do our offerings. Our selection of antibodies has expanded, along with other products, including human cells, specialized media, sera, and cell models. We continue to assess the needs of the neuroscience research field and add new resources to our neuroscience range to add to our cutting edge technologies. Currently, Creative Biolabs offers a range of specific tools & reagents to allow you stay at the forefront of your field. Creative Biolabs is your source for neural cells, media and supplements including iPSC-derived cells. Our large range of substrates and matrices including natural extracellular matrices and artificial scaffolds gives you numerous options to develop your in vitro system. We also offer innovative neural tracers and customized technical services that help researchers explore questions about genes, neurons, circuitry structure, function of brain network, mechanism and treatment of diseases. We also have an extensive biorepository with neural tissue from numerous species. We will always offer proven reagents for results you can trust and understand.
Table of Contents Contents By Research Area By Research Area 1 Neuroinflammation Markers 2 Synaptic Signaling Markers 3 Neural Lineage Markers 4 Neurodegenerative Diseases Markers 5 Development Markers 6 By Neural Cell Type By Neural Cell Type 7 Neuronal Markers 8 Microglia Markers 14 Astrocyte Markers 17 Oligodendrocyte Markers 18
Neural Antibodies Neural Antibodies Antibodies are valuable tools in the ongoing scientific effort to gain more knowledge about the human brain, to understand the fundamental and emergent properties of neurons and neural circuits, and to identify diseases such as neurological brain disorders. Therefore there is a necessary need for highlycharacterized and specific antibodies for neuroscience research. Our neuroscience catalog features a wide range of primary monoclonal and polyclonal antibodies for use in research designed to recognize the diverse neurochemical cell types in rodent and human nervous systems, validated in cell lines, rodents, and human tissues. Our antibodies are validated for use in IHC, WB, and ICC-IF. Why Creative Biolabs Antibodies? Why Creative Biolabs Antibodies? VERY RELIABLE ANTIBODIES VERY RELIABLE ANTIBODIES Creative Biolabs is the original manufacturer of over 21,000 primary antibodies targeting the majority of human proteins. Building on our heritage with the Human Protein project, we provide highly validated reagents that enable leading research in biology, diagnostics, and medicine for the purpose of understanding and improving human health. CREATED BY THE HUMAN PROTEIN CREATED BY THE HUMAN PROTEIN Our antibodies are developed within the prestigious Human Protein project. Our antibodies are validated in all major human tissues and organs and 20 cancer tissues. Each antibody is supported by over 500 staining images. VALIDATED BY ENHANCED VALIDATION VALIDATED BY ENHANCED VALIDATION We take great care to validate our antibodies in IHC, WB, and ICC-IF. As an additional layer of security, we perform Enhanced Validation. By using 5 different enhanced validation methods we validate our antibodies for each combination of protein, sample, and application. EVIDENCED BY SCIENCE EVIDENCED BY SCIENCE Our antibodies are used all over the world and referenced in 1000s of scientific peer-reviewed papers. 1
Neuroinflammation Neuroinflammation Neuroinflammation broadly defines the collective reactive immune response in the brain and spinal cord in response to injury and disease. Inflammation in the central nervous system (CNS) is commonly associated with various degrees of tissue damage, such as loss of myelin and neurons. The neuroinflammatory process is complex and involves disruption of the blood-brain barrier, peripheral leukocyte infiltration, edema, and gliosis. New Monoclonals for Neuroinflammation New Monoclonals for Neuroinflammation Cat Cat NAB2007FY1767 NAB2007FY1768 NAB2007FY1769 NAB2007FY1770 NAB2007FY1771 NAB2007FY1772 NAB2007FY1773 NAB2007FY1774 NAB2007FY1775 NAB2007FY1776 NAB2007FY1777 NAB2007FY1778 NAB2007FY1779 NAB2007FY1780 NAB2007FY1781 NAB2007FY1782 NAB2007FY1783 NAB2007FY1784 NAB2007FY1785 NAB2007FY1786 NAB2007FY1787 NAB2007FY1788 NAB2007FY1789 NAB2007FY1790 NAB2007FY1791 NAB2007FY1792 NAB2007FY1793 NAB2007FY1794 NAB2007FY1795 Product Name Product Name Anti-AGER Anti-AGER Anti-MS4A1 Anti-PLP1 Anti-ANO2 Anti-ANO2 Anti-CD163 Anti-CD163 Anti-GZMB Anti-SPP1 Anti-SERPINA3 Anti-CRYAB Anti-CRYAB Anti-GAP43 Anti-GAP43 Anti-GAP43 Anti-DYSF Anti-AIF1 Anti-AIF1 Anti-HLA-DRA Anti-HLA-DRA Anti-HLA-DRA Anti-AMIGO3 Anti-IL7 Anti-OPALIN Anti-OPALIN Anti-S100A8 Anti-S100A9 Anti-TRPM4 Clonality Clonality Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Applications Applications IHC IHC IHC; WB IHC IHC IHC IHC; WB IHC IHC IHC IHC IHC; WB; IF IHC; WB IHC IHC IHC IHC; WB IHC IHC IHC; WB IHC; WB IHC; WB WB IF IHC IHC IHC IHC IHC; WB; IF New New Polyclonals Polyclonals for Neuroinflammation for Neuroinflammation Product Name Product Name Anti-SERPINA3 Anti-SERPINA3 Anti-GZMB Anti-PLP1 Anti-GAP43 Anti-MS4A1 Anti-OPALIN Anti-MS4A1 Anti-GAP43 Anti-DYSF Anti-IL7 Anti-DYSF Anti-S100A8 Anti-SPP1 Anti-GPR17 Anti-TRPM4 Anti-RGMA Anti-CD163 Anti-AIF1 Anti-HLA-DRA Anti-CD163 Anti-HLA-DRA Anti-CRYAB Anti-ANO2 Anti-AGER Anti-ITGA4 Clonality Clonality Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Applications Applications IHC; WB IHC; WB IHC; WB IHC IHC; IF IHC; WB; IF IHC IHC; WB IHC; IF IHC; IF IHC IHC IHC; WB; IF IHC; WB; IF IHC IHC; IF IF IHC IHC IHC IHC IHC IHC IHC WB; IF IF Cat Cat NAB2007FY1805 NAB2007FY1822 NAB2007FY1837 NAB2007FY1845 NAB2007FY1894 NAB2007FY1898 NAB2007FY1899 NAB2007FY1900 NAB2007FY1903 NAB2007FY1908 NAB2007FY1920 NAB2007FY1929 NAB2007FY1941 NAB2007FY1950 NAB2007FY1961 NAB2007FY1989 NAB2007FY1995 NAB2007FY2000 NAB2007FY2006 NAB2007FY2007 NAB2007FY2014 NAB2007FY2015 NAB2007FY2018 NAB2007FY2019 NAB2007FY2027 NAB2007FY2028 2
Synaptic Signaling Synaptic Signaling Synaptic signaling is cell-cell communication that occurs at the synaptic level. Cells communicate with each other via direct contact (juxtacrine signaling), over short distances (paracrine signaling), or vast distances and scales (endocrine signaling). The predominant excitatory neurotransmitter in the brain, is glutamate (GLU). The inhibitory neurotransmitters, GABA (in the brain) and glycine (in the brainstem and spinal cord) are common amino acids that participate in multiple metabolic cycles. Calcium (Ca2+) signaling in neurons is critical in cell signaling. Calbindin 2 (also known as calretinin), is one of the Ca2+- binding proteins involved in Ca2+ signaling that facilitates cytosolic Ca2+ diffusion without interfering with Ca2+ signaling. Selected Monoclonals and Polyclonals for Synaptic Signaling Selected Monoclonals and Polyclonals for Synaptic Signaling Cat Cat Product Name Product Name Clonality Clonality Applications Applications Cat Cat Product Name Product Name Clonality Clonality Applications Applications NAB2007FY1931 Anti-ATF2 Polyclonal Human NAB2007FY1952 Anti-KIF26B Polyclonal Human NAB2007FY1975 Anti-KIF4A Polyclonal Human NAB2007FY1719 Anti-ATF3 Monoclonal Human NAB2007FY1849 Anti-KIF5A Polyclonal Human; Mouse; Rat NAB2007FY1812 Anti-ATF3 Polyclonal Human NAB2007FY1977 Anti-KIF5C Polyclonal Human NAB2007FY1892 Anti-ATP1B1 Polyclonal Human NAB2007FY1994 Anti-KIF7 Polyclonal Human NAB2007FY1887 Anti-ATP1B2 Polyclonal Human NAB2007FY1939 Anti-KIFAP3 Polyclonal Human NAB2007FY1945 Anti-CAMK2B Polyclonal Human; Mouse NAB2007FY1965 Anti-MAPK1 Polyclonal Human NAB2007FY1935 Anti-CALB1 Polyclonal Human NAB2007FY1854 Anti-MAPK3 Polyclonal Human; Mouse; Rat NAB2007FY1870 Anti-CALB2 Polyclonal Human; Mouse; Rat NAB2007FY1904 Anti-GRM1 Polyclonal Human NAB2007FY1869 Anti-CALB2 Polyclonal Human NAB2007FY2012 Anti-GRM8 Polyclonal Human NAB2007FY1944 Anti-CAMK2D Polyclonal Human NAB2007FY1922 Anti-NCS1 Polyclonal Human; Mouse NAB2007FY1915 Anti-FOS Polyclonal Human NAB2007FY1864 Anti-PRKCA Polyclonal Human; Mouse; Rat NAB2007FY1757 Anti-CHAT Monoclonal Human; Mouse; Rat NAB2007FY2016 Anti-PRKCH Polyclonal Human NAB2007FY2001 Anti-CHAT Polyclonal Human; Mouse NAB2007FY2010 Anti-PNMT Polyclonal Human NAB2007FY1960 Anti-PRKACB Polyclonal Human NAB2007FY1897 Anti-CHRM1 Polyclonal Human NAB2007FY1927 Anti-PRKCZ Polyclonal Human; Mouse NAB2007FY1873 Anti-CLIC4 Polyclonal Human NAB2007FY1831 Anti-RAB3A Polyclonal Human NAB2007FY1918 Anti-CREB1 Polyclonal Human; Mouse; Rat NAB2007FY1732 Anti-VGLUT1 Monoclonal Human; Mouse; Rat NAB2007FY1748 Anti-DDC Monoclonal Human; Mouse; Rat NAB2007FY2021 Anti-VGAT Polyclonal Human NAB2007FY1910 Anti-DDC Polyclonal Human NAB2007FY1754 Anti-NET Monoclonal Human; Mouse; Rat NAB2007FY1884 Anti-SLC1A2 Polyclonal Human NAB2007FY1803 Anti-GABRA3 Polyclonal Human; Mouse NAB2007FY1755 Anti-DAT Monoclonal Human; Mouse; Rat NAB2007FY2011 Anti-GABRB1 Polyclonal Human NAB2007FY1816 Anti-SNAP25 Polyclonal Human; Mouse NAB2007FY1972 Anti-SNAP29 Polyclonal Human NAB2007FY1978 Anti-GABRG1 Polyclonal Human NAB2007FY1919 Anti-SST Polyclonal Human; Mouse NAB2007FY1743 Anti-GAD1 Monoclonal Human; Mouse; Rat NAB2007FY1875 Anti-STXBP1 Polyclonal Human; Mouse; Rat NAB2007FY2020 Anti-GAD1 Polyclonal Human NAB2007FY1839 Anti-STXBP6 Polyclonal Human NAB2007FY1734 Anti-GAD2 Monoclonal Human; Mouse; Rat NAB2007FY1959 Anti-SYNGR1 Polyclonal Human NAB2007FY1996 Anti-GAD2 Polyclonal Human NAB2007FY2025 Anti-SYNPR Polyclonal Human NAB2007FY1893 Anti-SLC6A1 Polyclonal Human; Mouse; Rat NAB2007FY1827 Anti-SYP Polyclonal Human NAB2007FY1982 Anti-SLC6A11 Polyclonal Human NAB2007FY1888 Anti-SYT12 Polyclonal Human NAB2007FY1879 Anti-GRIA2 Polyclonal Human NAB2007FY1999 Anti-SYT13 Polyclonal Human NAB2007FY1848 Anti-SYT16 Polyclonal Human NAB2007FY1896 Anti-HTR2A Polyclonal Human NAB2007FY1992 Anti-TGFA Polyclonal Human NAB2007FY1990 Anti-SLC12A7 Polyclonal Human; Mouse; Rat NAB2007FY1909 Anti-KCNJ5 Polyclonal Human NAB2007FY1753 Anti-TH Monoclonal Human; Mouse; Rat NAB2007FY1885 Anti-KIF11 Polyclonal Human; Mouse; Rat NAB2007FY2023 Anti-TH Polyclonal Human; Mouse NAB2007FY1973 Anti-KIF17 Polyclonal Human NAB2007FY1752 Anti-TPH2 Monoclonal Human; Mouse; Rat NAB2007FY1986 Anti-KIF18A Polyclonal Human NAB2007FY2008 Anti-VAMP4 Polyclonal Human NAB2007FY1942 Anti-KIF1C Polyclonal Human NAB2007FY1980 Anti-VAMP7 Polyclonal Human 3
Neural Lineage Neural Lineage During central nervous system development, neural stem cells (NSCs) proliferate and divide to generate a progeny that differentiate into neurons, astrocytes, oligodendrocytes, and different glial cells. NSCs self-renewal and differentiation are regulated by a precise temporal sequence of growth factors, intracellular signaling, and transcription factor expression. NSCs and their differentiated progeny can be identified by the expression of a unique combination of cell surface markers and transcription factors. The glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein and a well-known marker for astrocytes. Oligodendrocytes can convert extracellular 2’,3’-cAMP to adenosine. As CNPase is the predominant enzyme involved in this conversion, the cyclic nucleotide phosphodiesterase (CNP) is widely used as an oligodendrocyte marker. Neurons express the neurofilament medium (NFEM) polypeptide other intermediate filament proteins, including nestin, synemin, syncoilin and vimentin. Selected Monoclonals and Polyclonals for Neural Lineage Selected Monoclonals and Polyclonals for Neural Lineage Target Cells Target Cells Astrocytes Astrocytes Astrocytes Astrocytes Astrocytes Astrocytes Astrocytes Astroglia Astroglia Calcium binding protein Calcium binding protein Calcium binding protein Calcium binding protein Calcium binding protein Calcium binding protein Calcium binding protein Cytoskeleton Cytoskeleton Cytoskeleton Cytoskeleton Cytoskeleton Cytoskeleton Cytoskeleton Cytoskeleton Microglia Microglia Microglia Microglia Microglia Microglia Microglia Neurons Neurons Neurons Neurons Neurons Neurons Neurons Neurons Neurons Neurons Oligodendrocytes Oligodendrocytes Oligodendrocytes Oligodendrocytes Oligodendrocytes Oligodendrocytes Oligodendrocytes Progenitors Progenitors Progenitors Schwann cells Schwann cells Schwann cells Cat Cat NAB2007FY1730 NAB2007FY1731 NAB2007FY1749 NAB2007FY1750 NAB2007FY1751 NAB2007FY1871 NAB2007FY2017 NAB2007FY1724 NAB2007FY1926 NAB2007FY1697 NAB2007FY1710 NAB2007FY1711 NAB2007FY1865 NAB2007FY1895 NAB2007FY1905 NAB2007FY1938 NAB2007FY1809 NAB2007FY1817 NAB2007FY1860 NAB2007FY1874 NAB2007FY1876 NAB2007FY1932 NAB2007FY1933 NAB2007FY1984 NAB2007FY1687 NAB2007FY1717 NAB2007FY1720 NAB2007FY1760 NAB2007FY1799 NAB2007FY2003 NAB2007FY2013 NAB2007FY1686 NAB2007FY1725 NAB2007FY1726 NAB2007FY1727 NAB2007FY1728 NAB2007FY1729 NAB2007FY1758 NAB2007FY1814 NAB2007FY1859 NAB2007FY2024 NAB2007FY1738 NAB2007FY1739 NAB2007FY1740 NAB2007FY1741 NAB2007FY1742 NAB2007FY1928 NAB2007FY1936 NAB2007FY1716 NAB2007FY1800 NAB2007FY1855 NAB2007FY1735 NAB2007FY1736 NAB2007FY1737 Product Name Product Name Anti-GFAP Anti-S100B Anti-GLUL Anti-GLUL Anti-GLUL Anti-GLUL Anti-GFAP Anti-EZR Anti-EZR Anti-SCGN Anti-NECAB1 Anti-NECAB2 Anti-SCGN Anti-NECAB2 Anti-S100B Anti-NECAB1 Anti-MYO5A Anti-ACTN4 Anti-ACTN1 Anti-INA Anti-MAP2 Anti-MAP1B Anti-NEFM Anti-MAP1A Anti-CD45 Anti-CD68 Anti-ITGAM Anti-TMEM119 Anti-CD45 Anti-CD68 Anti-TMEM119 Anti-VIM Anti-NEFH Anti-NEFM Anti-NEFM Anti-NEFM Anti-NEFM Anti-UCHL1 Anti-VIM Anti-UCHL1 Anti-NEFH Anti-MOG Anti-MOG Anti-CNP Anti-CNP Anti-CNP Anti-MOG Anti-CNP Anti-MKI67 Anti-MKI67 Anti-PBK Anti-MBP Anti-MBP Anti-MBP Clonality Clonality Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Polyclonal Polyclonal Monoclonal Polyclonal Monoclonal Monoclonal Monoclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Monoclonal Monoclonal Monoclonal Monoclonal Polyclonal Polyclonal Polyclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Polyclonal Polyclonal Polyclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Polyclonal Polyclonal Monoclonal Polyclonal Polyclonal Monoclonal Monoclonal Monoclonal Applications Applications IHC; WB IHC; WB IHC; WB IHC; WB IHC IHC; IF IHC; WB IHC; WB IHC; WB; IF IHC; WB IHC; WB IHC; WB IHC; WB IHC; WB IHC; WB IHC; WB IHC; WB; IF IHC; WB; IF IHC; WB IHC; WB IHC; WB IHC; WB IHC; WB IHC; WB; IF IHC; WB IHC; WB IHC; WB IHC; WB; IF IHC; WB; IF IHC IHC; IF IHC; IF IHC; WB; IF IHC; WB; IF IHC; WB; IF IHC; WB; IF IHC; WB IHC; WB IHC; WB IHC; WB; IF IHC; IF IHC; WB; IF IHC; WB; IF IHC; WB; IF IHC IHC; WB; IF IHC; WB; IF IHC; WB; IF IHC; WB IHC IHC; WB IHC IHC; WB; IF IHC 4
Neurodegenerative Diseases Neurodegenerative Diseases Neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis, Parkinson’s, Alzheimer’s and Huntington’s diseases, occur as a result of the progressive loss of structure and function in neurons, leading to the death of neurons. Age remains the primary risk factor for almost all the neurodegenerative disorders; thus, interfering with age-related molecular mechanisms or pathways might be an avenue to develop new therapeutics. The choline acetyltransferase (ChAT) is an enzyme responsible for catalyzing the synthesis of acetylcholine and is expressed in the majority of cholinergic neurons. Hence, ChAT immunoreactivity is used to detect cognitive decline in several neurodegenerative disorders. Integral membrane protein 2B (ITM2B) is a protein that in humans is encoded by the ITM2B gene. This gene, located on chromosome 13, is connected to familial dementia, causing amyloid and prefibrillar effects similar to those seen in Alzheimer’s. The expression of the ubiquitin-carboxyl-terminal hydrolase isozyme L1 (UCHL1), present both in the neuronal cells of the central and peripheral nervous system, is down-regulated in Parkinson’s and Alzheimer’s disease patients. Selected Monoclonals and Polyclonals for Neurodegeneration Selected Monoclonals and Polyclonals for Neurodegeneration Cat Cat NAB2007FY1688 NAB2007FY1689 NAB2007FY1690 NAB2007FY1691 NAB2007FY1698 NAB2007FY1701 NAB2007FY1704 NAB2007FY1705 NAB2007FY1706 NAB2007FY1707 NAB2007FY1712 NAB2007FY1714 NAB2007FY1715 NAB2007FY1718 NAB2007FY1722 NAB2007FY1723 NAB2007FY1759 NAB2007FY1761 NAB2007FY1762 NAB2007FY1763 NAB2007FY1764 NAB2007FY1765 NAB2007FY1766 NAB2007FY1767 NAB2007FY1768 NAB2007FY1769 NAB2007FY1770 NAB2007FY1771 NAB2007FY1772 NAB2007FY1773 NAB2007FY1774 NAB2007FY1775 NAB2007FY1776 NAB2007FY1777 NAB2007FY1778 NAB2007FY1779 NAB2007FY1780 NAB2007FY1781 NAB2007FY1782 NAB2007FY1783 NAB2007FY1784 NAB2007FY1785 NAB2007FY1786 NAB2007FY1787 NAB2007FY1788 NAB2007FY1789 NAB2007FY1790 NAB2007FY1791 NAB2007FY1792 NAB2007FY1793 NAB2007FY1794 NAB2007FY1795 NAB2007FY1796 NAB2007FY1797 NAB2007FY1805 NAB2007FY1808 NAB2007FY1810 NAB2007FY1811 NAB2007FY1815 NAB2007FY1820 Product Name Product Name Anti-CHGA Anti-ADAR Anti-AQP4 Anti-FUS Anti-TTR Anti-USP46 Anti-CD4 Anti-APOA4 Anti-ATRX Anti-PHGDH Anti-AKT1 Anti-NSD2 Anti-RHOT1 Anti-CD40 Anti-VWF Anti-VPS26A Anti-PFN1 Anti-IL17A Anti-IL17RA Anti-IL17RA Anti-GPR17 Anti-CXCL13 Anti-TLR2 Anti-AGER Anti-AGER Anti-MS4A1 Anti-PLP1 Anti-ANO2 Anti-ANO2 Anti-CD163 Anti-CD163 Anti-GZMB Anti-SPP1 Anti-SERPINA3 Anti-CRYAB Anti-CRYAB Anti-GAP43 Anti-GAP43 Anti-GAP43 Anti-DYSF Anti-AIF1 Anti-AIF1 Anti-HLA-DRA Anti-HLA-DRA Anti-HLA-DRA Anti-AMIGO3 Anti-IL7 Anti-OPALIN Anti-OPALIN Anti-S100A8 Anti-S100A9 Anti-TRPM4 Anti-ITGA4 Anti-RGMA Anti-SERPINA3 Anti-PTGS2 Anti-SOD1 Anti-APP Anti-SOD2 Anti-VWF Clonality Clonality Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Monoclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Applications Applications IHC; WB; IF IHC; WB; IF IHC; WB IHC; WB; IF IHC; WB WB; IF IHC; WB IHC; WB IHC; WB; IF IHC; WB; IF WB; IF IHC; WB; IF IHC; WB IHC; WB IHC; WB IHC; WB; IF IHC; WB IHC WB WB IHC; WB IHC WB IHC IHC IHC; WB IHC IHC IHC IHC; WB IHC IHC IHC IHC IHC; WB; IF IHC; WB IHC IHC IHC IHC; WB IHC IHC IHC; WB IHC; WB IHC; WB WB IF IHC IHC IHC IHC IHC; WB; IF WB WB IHC; WB IHC; IF IHC; WB; IF IHC; WB IHC; WB IHC; WB Cat Cat NAB2007FY1822 NAB2007FY1824 NAB2007FY1826 NAB2007FY1829 NAB2007FY1833 NAB2007FY1834 NAB2007FY1837 NAB2007FY1842 NAB2007FY1845 NAB2007FY1847 NAB2007FY1853 NAB2007FY1858 NAB2007FY1867 NAB2007FY1877 NAB2007FY1886 NAB2007FY1894 NAB2007FY1898 NAB2007FY1899 NAB2007FY1900 NAB2007FY1901 NAB2007FY1903 NAB2007FY1906 NAB2007FY1907 NAB2007FY1908 NAB2007FY1911 NAB2007FY1912 NAB2007FY1913 NAB2007FY1914 NAB2007FY1920 NAB2007FY1923 NAB2007FY1925 NAB2007FY1929 NAB2007FY1937 NAB2007FY1941 NAB2007FY1948 NAB2007FY1949 NAB2007FY1950 NAB2007FY1951 NAB2007FY1955 NAB2007FY1956 NAB2007FY1961 NAB2007FY1967 NAB2007FY1974 NAB2007FY1979 NAB2007FY1987 NAB2007FY1989 NAB2007FY1993 NAB2007FY1995 NAB2007FY1997 NAB2007FY2000 NAB2007FY2006 NAB2007FY2007 NAB2007FY2014 NAB2007FY2015 NAB2007FY2018 NAB2007FY2019 NAB2007FY2027 NAB2007FY2028 Product Name Product Name Anti-SERPINA3 Anti-CASP3 Anti-PTGS1 Anti-CTSD Anti-HYPM Anti-OPTN Anti-GZMB Anti-ADAR Anti-PLP1 Anti-PARK7 Anti-APBB3 Anti-LRP2 Anti-TNFRSF21 Anti-ATXN1 Anti-RHOT1 Anti-GAP43 Anti-MS4A1 Anti-OPALIN Anti-MS4A1 Anti-AQP4 Anti-GAP43 Anti-NSD2 Anti-PADI4 Anti-DYSF Anti-HIP1 Anti-CTSB Anti-ATXN2 Anti-AIMP1 Anti-IL7 Anti-C3 Anti-PHGDH Anti-DYSF Anti-APBB2 Anti-S100A8 Anti-NFKB1 Anti-HTRA2 Anti-SPP1 Anti-GSK3B Anti-UBE2K Anti-ITM2B Anti-GPR17 Anti-PSEN1 Anti-FBXO7 Anti-SNCB Anti-AOX1 Anti-TRPM4 Anti-PRNP Anti-RGMA Anti-APBA3 Anti-CD163 Anti-AIF1 Anti-HLA-DRA Anti-CD163 Anti-HLA-DRA Anti-CRYAB Anti-ANO2 Anti-AGER Anti-ITGA4 Clonality Clonality Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Polyclonal Applications Applications IHC; 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Development Development The development of the central nervous system includes the development of the brain, spinal cord, optic, and auditory systems. Within the neural tube, stem cells generate the two major classes of cells that make the majority of the nervous system: neurons and glia. Both these classes of cells differentiate into many different types generated with highly specialized functions and shapes. The development of the peripheral and central nervous systems begins early in embryogenesis and can be traced through the use of lineage antibodies specific to each stage of neuronal development. The (SOX) family of transcription factors are well-established regulators of cell fate decisions during development. Vimentin (VIM) is a type III intermediate filament protein expressed in mesenchymal cells. It is often used as a marker of mesenchymally-derived cells or cells undergoing an epithelial-tomesenchymal transition (EMT) during both healthy development and metastatic progression. The cell surface glycoprotein Thy1 (CD90) is expressed on many mammalian cell types, including neurons, and serves as a human mesenchymal stem cell (MSC) marker. Selected Monoclonals and Polyclonals for Development Selected Monoclonals and Polyclonals for Development Cat Cat Product Name Product Name Clonality Clonality Applications Applications NAB2007FY1685 Anti-SOX11 Monoclonal IHC; WB NAB2007FY1692 Anti-NES Monoclonal IHC; WB; IF NAB2007FY1693 Anti-RUNX2 Monoclonal IHC; WB; IF NAB2007FY1694 Anti-FABP7 Monoclonal IHC; WB NAB2007FY1695 Anti-VANGL1 Monoclonal WB; IF NAB2007FY1696 Anti-TSPAN7 Monoclonal IHC; WB NAB2007FY1699 Anti-SATB2 Monoclonal IHC; WB; IF NAB2007FY1700 Anti-FLT1 Monoclonal IHC; WB NAB2007FY1702 Anti-MEF2C Monoclonal IHC; WB; IF NAB2007FY1703 Anti-REST Monoclonal IHC; IF NAB2007FY1709 Anti-SOX9 Monoclonal IHC; WB; IF NAB2007FY1713 Anti-THY1 Monoclonal IHC; WB NAB2007FY1721 Anti-ENG Monoclonal IHC NAB2007FY1801 Anti-SOX11 Polyclonal IHC; WB NAB2007FY1819 Anti-SOX6 Polyclonal IHC; IF NAB2007FY1830 Anti-TSPAN7 Polyclonal IHC; WB NAB2007FY1838 Anti-NKX2-2 Polyclonal IHC; WB NAB2007FY1841 Anti-THY1 Polyclonal IHC; IF NAB2007FY1846 Anti-RUNX1 Polyclonal IHC; IF NAB2007FY1851 Anti-MEF2C Polyclonal IHC; WB; IF NAB2007FY1852 Anti-GLI3 Polyclonal IHC NAB2007FY1861 Anti-SOX30 Polyclonal IHC; WB NAB2007FY1868 Anti-NES Polyclonal IHC; WB NAB2007FY1882 Anti-SOX7 Polyclonal IHC; WB NAB2007FY1889 Anti-ENG Polyclonal IHC; WB NAB2007FY1924 Anti-NACC1 Polyclonal IHC; IF NAB2007FY1930 Anti-RUNX2 Polyclonal IHC; WB; IF NAB2007FY1953 Anti-FABP7 Polyclonal IHC; WB NAB2007FY1958 Anti-SATB2 Polyclonal IHC; WB; IF NAB2007FY1963 Anti-SOX4 Polyclonal IHC; IF NAB2007FY1968 Anti-PAX6 Polyclonal IHC; IF 6
Neural Cell Markers Neural Cell Markers Neurons and glia in neural tissue or cultures are commonly visualized and identified by immunodetection of cell-specific antigenic markers, including transcription factors, enzymes, cytoskeletal proteins, cell surface proteins, and secreted factors. Creative Biolabs offers multiple antibodies directed against these intracellular and cell surface proteins that can be used for the identification and characterization of different neural cell types. Neuron Microglia Astrocyte Neural Progenitor Cell Neural Stem Cell Oligodendrocyte 7
Neuronal Markers Neuronal Markers The nervous system consists of a complex variety of neurons and non-neuronal cells. The neuronal compartment alone contains billions of neurons, with a not yet fully characterized number of neuronal subtypes. Neurons are electrically excitable cells that transmit signals (electrical and chemical) supporting a wide range of functions including cognition, sensory perception and movement. Morphologically, neurons contain four well defined structural compartments including dendrites, soma, axon and synaptic terminal. General Markers General Markers Nuclear NeuroD1 RBFOX3/NeuN Cytoplasmic Calbindin D Doublecortin Enolase2/Neuron- Specific Enolase MAP2 NF-H NF-L NF-M PSD-93 PSD-95 Tau -III Tubulin UCH-L1/PGP9.5 Marker Marker Catalog # Catalog # Species Species Clonality Clonality Applications Applications Calbindin D NRZP-0622-ZP92 Human Poly WB, IHC Calbindin D-28K NRZP-0622-ZP93 Human; Mouse; Rat Mono WB, ICC Doublecortin NRZP-0622-ZP94 Human; Mouse; Rat Mono WB, ICC NRZP-0622-ZP95 Human Mono ICC, IHC, IP Enolase 2/Neuron - Specific Enolase NRZP-0622-ZP96 Human; Mous Poly WB, IHC NRZP-0622-ZP97 Human; Mouse; Rat Mono WB, ICC MAP2 NRZP-0622-ZP98 Human Mono ICC, IHC NeuroD1 NRZP-0622-ZP99 Human; Mous Poly WB, ICC NRZP-0622-ZP100 Human; Mouse; Rat Poly WB, ICC, IHC, ELISA NF-H NRZP-0622-ZP101 Human Poly WB, IHC NRZP-0622-ZP102 Human; Mouse; Rat Poly WB, ICC, IHC NF-L NRZP-0622-ZP103 Human Mono WB, IHC NRZP-0622-ZP104 Human; Mouse; Rat Poly WB, ICC, IHC NF-M NRZP-0622-ZP105 Human Poly WB, IHC PSD-93 NRZP-0622-ZP106 Human; Mouse; Rat Poly WB, ICC, IHC PSD-95 NRZP-0622-ZP107 Human; Mouse; Rat Mono WB, ICC, IHC, Block; Neut, ChIP, FC, IP RBFOX3/NeuN NRZP-0622-ZP108 Human; Mouse; Rat Poly WB, ICC, IHC NRZP-0622-ZP109 Wide specie Mono WB, IHC Tau NRZP-0622-ZP110 Wide specie Poly WB, IHC β-III Tubulin NRZP-0622-ZP111 Human; Mouse; Rat Poly WB, ICC, IHC β-IIITubulin,Neuron-Specific NRZP-0622-ZP112 Wide specie Mono WB, ICC UCH-L1/PGP9.5 NRZP-0622-ZP113 Human Mono WB, IHC, IP Neurogenic Differentiation factor 1 (NeuroD1) was detected in immersion fixed beta TC-6 mouse beta cell insulinoma cell line using Human/Mouse NeuroD1 Antigen Affinity-purified Polyclonal Antibody (Catalog # NRZP-0622-ZP99) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue). NF-L was detected in immersion fixed paraffin- embedded sections of human brain (substantia nigra) using Mouse Anti-Human NF-L Monoclonal Antibody (Catalog # NRZP-0622-ZP103) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti- Mouse IgG HRP Polymer Antibody. Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in neurons. Tau was detected in immersion fixed paraffin-embedded sections of human Alzheimer's brain using Mouse Anti-Tau Monoclonal Antibody (Catalog # NRZP-0622-ZP109) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal cell bodies and processes. 8
Dendritic Markers Dendritic Markers Cytoplasmic ARC/ARG3.1 Drebrin1 MAP2 SAP102 Marker Marker ARC/ARG3.1 Catalog # Catalog # NRZP-0622-ZP114 NRZP-0622-ZP115 NRZP-0622-ZP116 NRZP-0622-ZP117 NRZP-0622-ZP118 Specie Specie Human Human; Mouse; Rat Human Human; Mouse; Rat Human Clonality Clonality Poly Mono Poly Mono Mono Applications Applications WB, IHC WB, ICC, IHC, IP WB, ICC WB, ICC ICC, IHC Drebrin 1 MAP2 SAP102 NRZP-0622-ZP119 Human; Mouse; Rat Poly WB, IHC Axonal Markers Axonal Markers Cytoplasmic Kinesin 5A Kinesin 5B L1CAM NF-H NF-L Peripherin Tau -III Tubulin Cell Surface L1CAM Marker Catalog # Specie Clonality Applications Kinesin 5A NRZP-0622-ZP120 Human; Mouse; Rat Poly WB, ICC, IHC, ELISA Kinesin 5B NRZP-0622-ZP121 Human; Mouse; Rat Poly ICC, IHC NRZP-0622-ZP122 Human; Mous Mono WB, ICC, IHC, CyTOF, ELISA, FC, IP L1CAM NRZP-0622-ZP123 Human Poly WB, IHC NRZP-0622-ZP124 Human; Mouse; Rat Poly WB, ICC, IHC, ELISA NF-H NRZP-0622-ZP125 Human Poly WB, IHC NRZP-0622-ZP126 Human; Mouse; Rat Poly WB, ICC, IHC NF-L NRZP-0622-ZP127 Human Mono WB, IHC Peripherin NRZP-0622-ZP128 Human; Mouse; Rat Poly WB, ICC, IHC, ELISA NRZP-0622-ZP129 Wide specie Mono WB, IHC Tau NRZP-0622-ZP130 Wide specie Poly WB, IHC -IIITubulin NRZP-0622-ZP131 Human; Mouse; Rat Poly WB, ICC, IHC -IIITubulin(CloneTuJ- 1),Neuron-Specific NRZP-0622-ZP132 Wide specie Mono WB, ICC Immunohistochemistry-Paraffin: ARC/ARG3.1 Antibody [NRZP-0622-ZP114] - Human adrenal tissue at an antibody concentration of 5ug/ml. Immunohistochemistry Free-Floating: MAP2 Antibody (5H11) [NRZP-0622-ZP117] - Analysis of rat hippocampus section stained with mouse mAb to MAP2, dilution 1:5,000 in green, and costained with rabbit pAb to alpha-internexin, dilution 1:2,000 in red. The NRZP- 0622-ZP117 antibody labels MAP2 protein in the perikarya and dendrites of the most neurons, and the alpha-internexin antibody selectively stains axons and dendrites of neuronal cells. Immunohistochemistry-Paraffin: SAP102 Antibody [NRZP- 0622-ZP119] - Staining of human colon shows no positivity in glandular cells as expected. 9
Presynaptic Markers Presynaptic Markers Marker Marker Catalog # Catalog # Specie Specie Human; Mouse; Rat Human; Mous Human Human; Mouse; Rat Human; Mouse; Rat Human; Mouse; Rat Human; Mouse; Rat Human; Mouse; Rat Human; Mouse; Rat Human Mous Rat Human Human Human; Mouse; Rat Human; Mous Human; Mous Human; Mouse; Rat Human Human; Mouse; Rat Human Clonality Clonality Applications Applications GAP-43 NRZP-0622-ZP133 Poly WB, ICC, IHC Neurexin 3/NRXN3 NRZP-0622-ZP134 Poly WB, IHC SNAP23 NRZP-0622-ZP135 Poly WB, ICC SNAP25 NRZP-0622-ZP136 Poly WB, ICC SV2A NRZP-0622-ZP137 Poly WB, ICC, IHC, IP Synapsin I NRZP-0622-ZP138 Poly WB, ICC, IHC, IP Synapsin II NRZP-0622-ZP139 Poly ICC WB, ICC, IHC, ELISA Synaptogyrin 1 NRZP-0622-ZP140 Poly NRZP-0622-ZP141 Poly WB, ICC, IHC *Cytoplasmic(plasma membrane) Synaptophysin NRZP-0622-ZP142 NRZP-0622-ZP143 NRZP-0622-ZP144 NRZP-0622-ZP145 NRZP-0622-ZP146 Mono Poly Mono Poly Mono ICC, IHC WB, ICC WB, IHC, IP WB, ICC, IHC WB, IHC GAP-43 SNAP23 SNAP25 Syntaxin 1A Synaptotagmin-1 *Cytoplasmic(synapticmembrane) Synaptotagmin-4 Synaptotagmin-1 Synaptotagmin-4 VAMP-1 VAMP-2 SV2A Synapsin I Synapsin II Synaptogyrin 1 Synaptophysin Syntaxin 1A NRZP-0622-ZP147 Poly WB, ICC VAMP-1 NRZP-0622-ZP148 Poly WB, IHC Cell Surface Neurexin 3/NRXN3 VGLUT1/SLC17A7 VAMP-2 NRZP-0622-ZP149 Mono WB, IHC VIAAT/SLC32A1/VGAT NRZP-0622-ZP150 Mono WB, IHC VGLUT1/SLC17A7 *Cytoplasmic marker is found associated with the membrane of the listed cell structure. NRZP-0622-ZP151 Mono IHC NRZP-0622-ZP152 Poly ICC, IHC VIAAT/SLC32A1/VGAT NRZP-0622-ZP153 Mono ICC Postsynaptic Markers Postsynaptic Markers Marker Marker Catalog # Catalog # Specie Specie Human; Mous Human Human; Mouse; Rat Human; Rat Human; Mouse; Rat Clonality Clonality Applications Applications NRZP-0622-ZP157 Mono WB, IHC Gephyrin/GPHN NRZP-0622-ZP158 Poly WB, IHC Cytoplasmic HOMER1 NRZP-0622-ZP159 Poly WB, ICC Gephyrin/GPHN HOMER1 PSD-95 SAP102 Shank1 Shank2 Shank3 Neuroligin 1/NLGN1 NRZP-0622-ZP160 Poly WB, IHC WB, ICC, IHC, ELISA WB, ICC, IHC, Block; Neut, ChIP, FC, IP Neuroligin 2/NLGN2 NRZP-0622-ZP161 Poly Cell Surface Neuroligin 1/NLGN1 Human; Mouse; Rat Neuroligin 2/NLGN2 PSD-95 NRZP-0622-ZP162 Mono Human; Mouse; Rat Human; Mouse; Rat Human Human Human; Rat SAP102 NRZP-0622-ZP163 Poly WB, IHC Shank1 NRZP-0622-ZP164 Poly WB, ICC, IHC NRZP-0622-ZP165 NRZP-0622-ZP166 NRZP-0622-ZP167 Mono Poly Mono IHC IHC WB, ICC, IHC Shank2 Shank3 Active Zone Markers Active Zone Markers Cytoplasmic Bassoon Piccolo Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications WB, ICC, IHC, IP WB, ICC, ELISA Bassoon NRZP-0622-ZP154 Mouse; Rat Mono NRZP-0622-ZP155 Mous Mono Piccolo NRZP-0622-ZP156 Human Poly IHC 10
Growth Cone Markers Growth Cone Markers Nuclear STRAP Cytoplasmic Coactosin-like COTL1 CRMP1 CRMP2 CRMP5 DCLK1 Doublecortin Drebrin 1 FABP7/B-FABP FARP2 STRAP Protein 1/ *Cytoplasmic(plasma membrane) BASP1 CAP1 GAP-43 GOProtein G Protein SNAP25 Inhibitor 2 *Cytoplasmic(endoplasmicreticulum) RTN1/NSP SPG3A *Cytoplasmic(earlyendosome) Syntaxin 7 Cell Surface L1CAM NCAM-1/CD56 Neuropilin-1 *Cytoplasmic marker is found associated with the membrane of the listed cell structure. Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications BASP1 NRZP-0622-ZP168 Human; Mouse; Rat Poly ICC, IHC CAP1 NRZP-0622-ZP169 Human; Mouse; Rat Poly WB, IHC Coactosin-like Protein 1/ COTL1 NRZP-0622-ZP170 Human; Mouse; Rat Poly WB, ICC CRMP1 NRZP-0622-ZP171 Human; Mouse; Rat Poly WB, ICC, IHC, ELISA CRMP2 NRZP-0622-ZP172 Human; Mouse; Rat Poly WB, ICC, IHC CRMP5 NRZP-0622-ZP173 Human; Mouse; Rat Mono WB, ICC, IHC DCLK1 NRZP-0622-ZP174 Human; Mouse; Rat Poly WB, ICC, IHC, ELISA Doublecortin NRZP-0622-ZP175 Human; Mouse; Rat Mono WB, ICC NRZP-0622-ZP176 Human; Mouse; Rat Mono WB, ICC, IHC, IP Drebrin 1 NRZP-0622-ZP177 Human Mono WB, ICC NRZP-0622-ZP178 Human; Rat Poly WB, ICC, IHC FABP7/B-FABP NRZP-0622-ZP179 Human Poly WB, IHC FARP2 NRZP-0622-ZP180 Human Poly WB, IHC GAP-43 NRZP-0622-ZP181 Human; Mouse; Rat Poly WB, ICC, IHC GOProtein NRZP-0622-ZP182 Human; Mous Poly WB, ICC, IHC, IP GProtein Inhibitor2 NRZP-0622-ZP183 Human; Mouse; Rat Poly ICC, IHC Growth Cone Antibody NRZP-0622-ZP184 Mouse; Rat Mono IHC NRZP-0622-ZP185 Human; Mous Mono WB, ICC, IHC, CyTOF, ELISA, FC, IP L1CAM NRZP-0622-ZP186 Human Poly WB, IHC NRZP-0622-ZP187 Human Mono WB, IHC, CyTOF, FC NCAM-1/CD56 NRZP-0622-ZP188 Human; Mous Poly WB, ICC, CyTOF, FC NRZP-0622-ZP189 Human Poly WB, IHC. Block; Neut, CyTOF, FC Neuropilin-1 NRZP-0622-ZP190 Mouse; Rat Poly WB, IHC, Block; Neut, CyTOF, FC RTN1 NRZP-0622-ZP191 Human; Mouse; Rat Mono WB, ICC, IHC RTN1-A/NSP NRZP-0622-ZP192 Rat Mono IHC SNAP25 NRZP-0622-ZP193 Human; Mouse; Rat Poly WB, ICC SPG3A NRZP-0622-ZP194 Human; Mouse; Rat Poly IHC STRAP NRZP-0622-ZP195 Human; Mous Poly WB, IHC Syntaxin 7 NRZP-0622-ZP196 Human; Mouse; Rat Poly WB, ICC 11
Cholinergic Neuron Markers Cholinergic Neuron Markers Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications Human; Mouse; Rat WB, ICC, IHC, ELISA, FC, GS, IP NRZP-0622- ZP197 Mono Acetylcholinesterase/ACHE NRZP-0622- ZP198 Human Poly IHC Human; Mouse; Rat NRZP-0622- ZP199 Poly WB, ICC, IHC Choline Acetyltransferase/ ChAT NRZP-0622- ZP200 Human Poly WB, IHC Human; Mouse; Rat NRZP-0622- ZP201 VAChT/SLC18A3 Poly WB, IHC Dopaminergic Neuron Markers Dopaminergic Neuron Markers Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications NRZP-0622- ZP202 Human; Mouse; Rat Dopamine -Hydroxylase Poly WB, ICC, IHC WB, ICC, CyTOF, ELISA, FC NRZP-0622- ZP203 Human Mono FOLR1 NRZP-0622- ZP204 NRZP-0622- ZP205 NRZP-0622- ZP206 NRZP-0622- ZP207 NRZP-0622- ZP208 Mous Poly ICC Human; Mouse; Rat Mono WB, IHC, FC HNF-3 /FoxA2 WB, ICC, ChIP WB, ICC, IHC, ELISA Human Poly Human; Mouse; Rat LMX1b Poly Nurr1/NGFI-B /NR4A2 Human; Mous Poly WB, IHC NRZP-0622- ZP209 Mouse; Rat; (Human; -ve WB, ICC, IHC, ELISA, IP SLC6A3/DAT1 Mono NRZP-0622- ZP210 NRZP-0622- ZP211 Human; Mouse; Rat Human; Mouse; Rat Poly WB, ICC, IHC Tyrosine Hydroxylase Poly WB, ICC GABAergic Neuron Markers GABAergic Neuron Markers Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications Human; Mouse; Rat NRZP-0622-ZP212 Poly WB, IHC GABABR1 NRZP-0622-ZP213 Rat Mono IHC GABABR2(N-Terminus) NRZP-0622-ZP214 Rat Poly WB, IHC Human; Mouse; Rat Human; Mouse; Rat Human; Mouse; Rat NRZP-0622-ZP215 Mono WB, IHC GAD1/GAD67 NRZP-0622-ZP216 Poly WB, IHC NRZP-0622-ZP217 Poly WB, ICC, IHC GAD2/GAD65 NRZP-0622-ZP218 Human Poly WB, IHC Human; Mouse; Rat Human; Mouse; Rat GAT-1/SLC6A1 NRZP-0622-ZP219 Poly WB, IHC NRZP-0622-ZP220 Poly ICC, IHC VIAAT/SLC32A1/VGAT NRZP-0622-ZP221 Human Mono ICC 12
Glutamatergic Neuron Markers Glutamatergic Neuron Markers Marker Marker Catalog # Catalog # Specie Specie Human; Mouse; Rat Human; Mouse; Rat Human; Mouse; Rat Human; Mouse; Rat Clonality Clonality Applications Applications Cytoplasmic Glutamine Synthetase Glutamine Synthetase NRZP-0622-ZP222 Poly WB, IHC Cell Surface WB, ICC, IHC, IP WB, ICC, IHC, FC, IP GRIN1/NMDAR1 NRZP-0622-ZP223 Mono GRIN1/NMDAR1 GRIN2B/NMDAR2B VGLUT1/SLC17A7 VGLUT2/SLC17A6 GRIN2B/NMDAR2B NRZP-0622-ZP224 Poly NRZP-0622-ZP225 Mono WB, IHC VGLUT1/SLC17A7 NRZP-0622-ZP226 Human Mono IHC Human; Mouse; Rat VGLUT2/SLC17A6 NRZP-0622-ZP227 Mono IHC Glycinergic Neuron Markers Glycinergic Neuron Markers Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications Human; Mouse; Rat Cell Surface VIAAT/SLC32A1/VGAT NRZP-0622-ZP228 Poly ICC, IHC VIAAT/SLC32A1/VGAT NRZP-0622-ZP229 Human Mono ICC Serotonergic Neuron Markers Serotonergic Neuron Markers Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications Nuclear Pet1 Dopa Decarboxylase/DCC Human; Mouse; Rat Human; Mouse; Rat WB, ICC, IHC, IP NRZP-0622-ZP230 Poly Cytoplasmic Pet1 NRZP-0622-ZP231 Poly ICC Tryptophan Hydroxylase/ TPH-1 Dopa Decarboxylase/DDC SLC6A44/ 5-HTTLPR/ Serotonin Transporter NRZP-0622-ZP232 Mouse; Rat Mono IHC, (WB–ve) Cell Surface SLC6A4/5-HTTLPR/ Serotonin Transporter Human; Mouse; Rat VMAT2 NRZP-0622-ZP233 Poly WB, IHC Tryptophan Hydroxylase 1/ TPH-1 NRZP-0622-ZP234 Human Poly WB, IHC Human; Mouse; Rat NRZP-0622-ZP235 Poly WB, IHC VMAT2 WB, IHC, CyTOF, FC NRZP-0622-ZP236 Human Mono Immunohistochemistry: VGLUT1 Antibody (2754) [NRZP-0622-ZP225] - Staining of rat brain shows strong positivity in glutamatergic processes in the molecular and granular layers of cerebellum. VIAAT/SLC32A1 was detected in immersion fixed 7- day differentiated rat cortical stem cells using Mouse Anti-Human VIAAT/SLC32A1 Monoclonal Antibody (Catalog # NRZP-0622-ZP229) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the Anti-Mouse IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to neurons. VMAT2 was detected in immersion fixed paraffin- embedded sections of human brain (substantia nigra) using Mouse Anti-Human VMAT2 Monoclonal Antibody (Catalog # NRZP-0622-ZP236) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti- Mouse HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal cell bodies. 13
Microglia Markers Microglia Markers Microglia markers include surface, intracellular (cytosolic proteins, gene transcripts), and released molecules. The general microglia markers can be detected irrespective of current cell phenotype. In the steady-state condition, microglia can be identified using several common markers which they share with macrophages, such as CD11b, CD45, CD68 and CX3CR1. When homeostasis is disturbed, microglia react by becoming “activated”. Markers of microglial activation depend on the activating stimulus. The classical model of macrophage activation are the M1 and M2 paradigm. Steady Steady- -State Microglia Markers State Microglia Markers Cytoplasmic AIF-1/Iba1 Cell Surface CD11b/Integrin CD45low CX3CR1 F4/80/EMR1 Fc RI/CD64 FCRL4/FcRH4 Secreted BDNF M M-CSF R/CD115 Mer P2Y12/P2RY12 Siglec-H TMEM119 IGF-I Marker Marker Catalog # Catalog # NRZP-0622-ZP237 NRZP-0622-ZP238 NRZP-0622-ZP239 NRZP-0622-ZP240 NRZP-0622-ZP241 Specie Specie Human; Mouse; Rat Human Human; Mouse; Rat Human Mous Clonality Clonality Poly Mono Poly Mono Mono Applications Applications WB, ICC, IHC, PEP-ELISA IHC WB, ICC, IHC, FC ICC, IHC, CyTOF, FC ICC, IHC, CyTOF, FC, IP AIF-1/Iba1 CD11b/Integrin M NRZP-0622-ZP242 Mous Mono WB, ICC, IHC, CyTOF, FA, FC, IP, IV CD45 NRZP-0622-ZP243 NRZP-0622-ZP244 NRZP-0622-ZP245 NRZP-0622-ZP246 NRZP-0622-ZP247 NRZP-0622-ZP248 NRZP-0622-ZP249 NRZP-0622-ZP250 NRZP-0622-ZP251 NRZP-0622-ZP252 NRZP-0622-ZP253 NRZP-0622-ZP254 NRZP-0622-ZP255 NRZP-0622-ZP256 NRZP-0622-ZP257 Human Mous Human; Mouse; Rat Human; Mous Human Mous Human Human Mous Mous Human Mous Human; Rat Mous Human Mono Poly Poly Mono Mono Mono Poly Mono Mono Poly Poly Mono Poly Mono Poly ICC, CyTOF, FC WB, ICC, CyTOF, FC ICC, IHC, ELISA, FC WB, ICC, IHC, EM, FC, IP, RI ICC, CyTOF, FC CyTOF, FC WB, IHC WB, IHC, CyTOF, ELISA, FC CyTOF, FC ICC, WB ICC WB, ICC WB, ICC, IHC, DB, ELISA, IP WB, IHC, CyTOF, FC IHC CX3CR1 F4/80/EMR1 Fc RI/CD64 FCRL4/FcRH4 M-CSF R/CD115 Mer P2Y12/P2RY12 Siglec-H TMEM119 Immunocytochemistry/Immunofluorescence: TMEM119 Antibody [NRZP-0622-ZP257] - Human microglia cell line stained with TMEM antibody and DAPI. Immunocytochemistry/Immunofluorescence: CX3CR1 Antibody [NRZP-0622-ZP245] - Staining of Human Heart cells with CX3CR1. Immunohistochemistry-Paraffin: CD45 Antibody (30- F11) [NRZP-0622-ZP242] - Staining of a FFPE mouse liver tissue section using 1:100 dilution of CD45 antibody (30-F11) [NRZP-0622-ZP242]. Signal was detected using AF488 conjugated donkey anti-rat secondary antibody at 1:500 dilution. 14
M1 Microglia Markers M1 Microglia Markers Cytoplasmic iNOS *Cytoplasmic(endoplasmicreticulum) COX-2 Cell Surface B7-1/CD80 B7-2/CD86 CD11b/Integrin CD36/SR-B3 CD40/TNFRSF5 CD68/SR-D1 Fc RII/CD32 Fc HLA-DR MHCClassII M RIII/CD16 Secreted CCL2/JE/MCP-1 CCL4/MIP- 1 CXCL1/GRO 1 CXCL10/IP-10 IFN- IL-1 /IL-1F2 IL-6 IL-12 IL-17/IL-17A IL- 18/IL-1F4 Nitric Oxide TNF- /KC/CINC- *Cytoplasmic marker is found associated with the membrane of the listed cell structure. Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications NRZP-0622-ZP258 Human Mono IHC, Block; Neut, CyTOF, ELISA, FC B7-1/CD80 NRZP-0622-ZP259 Mous Poly WB, ICC, Block; Neut, CyTOF, ELISA, FC NRZP-0622-ZP260 Human Poly WB, IHC, Block; Neut, CyTOF, FC B7-2/CD86 NRZP-0622-ZP261 Mous Mono WB, Block; Neut, CyTOF, FC NRZP-0622-ZP262 Rat Poly WB, IHC, CyTOF, ELISA, FC NRZP-0622-ZP263 Human; Mouse; Rat Poly WB, ICC, IHC, FC CD11b/Integrin M NRZP-0622-ZP264 Human Mono ICC, IHC, CyTOF, FC NRZP-0622-ZP265 Mous Mono ICC, IHC, CyTOF, FC, IP NRZP-0622-ZP266 Human; Mouse; Rat Poly WB, ICC, IHC CD36/SR-B3 NRZP-0622-ZP267 Human Mono ICC, CyTOF, FC NRZP-0622-ZP268 Mous Mono IHC, CyTOF, FC NRZP-0622-ZP269 Human Mono ICC, CyTOF, FC, FA NRZP-0622-ZP270 Mous Mono CyTOF, FC, FA, IP CD40/TNFRSF5 NRZP-0622-ZP271 Mous Poly WB, ICC NRZP-0622-ZP272 Human; Mouse; Rat Mono WB, ICC, IHC, FC, IP CD68/SR-D1 NRZP-0622-ZP273 Human Mono ICC, CyTOF, FC NRZP-0622-ZP274 Human; Mouse; Rat Poly WB, IHC COX-2 NRZP-0622-ZP275 Human; Mous Poly WB, ICC, CyTOF, FC NRZP-0622-ZP276 Human Mono WB, IHC, CyTOF, FC, IP HLA-DR NRZP-0622-ZP277 Mous Mono CyTOF, FC NRZP-0622-ZP278 Human Poly WB, ICC, Block; Neut, CyTOF, FC Fc RII/CD32 NRZP-0622-ZP279 Mous Poly WB, ICC NRZP-0622-ZP280 Human; Mouse; Rat Mono ICC, IHC, ELISA, FC Fc RIII/CD16 NRZP-0622-ZP281 Mous Poly WB, ICC, Block; Neut NRZP-0622-ZP282 Mous Mono WB, CyTOF, FC Fc RII/RIII(CD32/CD16) NRZP-0622-ZP283 Mous Poly ICC, WB NRZP-0622-ZP284 Human Mono IHC, FC, IP MHC Class II NRZP-0622-ZP285 Mous Mono WB, IHC, FC, IP NRZP-0622-ZP286 Rat Mono WB, ICC, IHC, CyTOF, FC, IP NRZP-0622-ZP287 Human; Mouse; Rat Poly WB, ICC, IHC iNOS NRZP-0622-ZP288 Human; Mouse; Rat Mono WB, IHC 15
M2 Microglia Markers M2 Microglia Markers Nuclear PPAR /NR1C3 Cytoplasmic Arginase 1/ARG1 Transglutaminase 2/TGM2 Cell Surface CD163 CLEC10A/CD301 DC- SIGN/CD209 HLA-DR MHCClassII MMR/CD206 Siglec-3/CD33 SR-AI TREM-2 Secreted BDNF FIZZ1/RELM IGF-I IL-1ra/IL-1F3 IL-4 IL-10 IL-13 TGF- YM1/Chitinase 2-like 3 Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications Arginase 1/ARG1 NRZP-0622-ZP289 Human; Mouse; Rat Poly WB, ICC, IHC, FC, IP NRZP-0622-ZP290 Human Mono ICC, IHC CD163 NRZP-0622-ZP291 Human Mono WB, CyTOF, FC NRZP-0622-ZP292 Human Poly WB, IHC CLEC10A/CD301 NRZP-0622-ZP293 Mous Mono ICC, IHC, FC NRZP-0622-ZP294 Human Mono WB, ICC, IHC, Block; Neut, CyTOF, FC DC-SIGN/CD209 NRZP-0622-ZP295 Mous Mono CyTOF, FC NRZP-0622-ZP296 Mous Poly WB, ICC, IHC, FC FIZZ1/RELM NRZP-0622-ZP297 Mous Mono WB, ICC NRZP-0622-ZP298 Human Mono WB, IHC, CyTOF, FC, IP HLA-DR NRZP-0622-ZP299 Mous Mono CyTOF, FC NRZP-0622-ZP300 Human Mono IHC, FC, IP NRZP-0622-ZP301 Mous Mono WB, IHC, FC, IP MHC Class II NRZP-0622-ZP302 Rat Mono WB, ICC, IHC, CyTOF, FC, IP NRZP-0622-ZP303 Human Mono WB, CyTOF, FC MMR/CD206 NRZP-0622-ZP304 Human Poly WB, ICC NRZP-0622-ZP305 Mous Poly WB, IHC, CyTOF, FC PPAR /NR1C3 NRZP-0622-ZP306 Human; Mouse; Rat Poly WB, IHC Siglec-3/CD33 NRZP-0622-ZP307 Human Poly WB, IHC, ELISA, FC SR-AI/MSR NRZP-0622-ZP308 Human; Mouse; Rat Poly WB, ICC, IHC Transglutaminase 2/TGM2 NRZP-0622-ZP309 Human; Mous Poly WB, ICC, IHC NRZP-0622-ZP310 Human Poly WB, ICC, CyTOF, FC TREM-2 NRZP-0622-ZP311 Mous Poly WB, ICC 16
Astrocyte Markers Astrocyte Markers Nuclear Galectin-3 HES-1 Notch-1 SOX9 Survivin Cytoplasmic ALDH1L1 Aldolase C Astrocytomas GFAP Glutamine Synthetase NDRG2 Notch-1 S100B Survivin *Cytoplasmic(plasma membrane) GAP-43 Cell Surface EAAT1/GLAST-1/SLC1A3 EAAT2/GLT1 A2B5 Aquaporin-4 Connexin 43/GJA1 *Cytoplasmic marker is found associated with the membrane of the listed cell structure. Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications A2B5 NRZP-0622-ZP312 Human; Mouse; Rat Mono ICC, CyTOF, FC ALDH1L1 NRZP-0622-ZP313 Human; Mouse; Rat Mono WB, ICC Aldolase C NRZP-0622-ZP314 Human; Mouse; Rat Poly WB, ICC, IHC Astrocytomas NRZP-0622-ZP315 Human; Rat Mono WB, ICC, IHC Aquaporin-4 NRZP-0622-ZP316 Human; Mouse; Rat Poly WB, ICC, IHC Connexin 43/GJA1 NRZP-0622-ZP317 Human; Mouse; Rat Poly WB, IHC NRZP-0622-ZP318 Human; Mouse; Rat Poly WB, ICC, IHC, ELISA, FC EAAT1/GLAST-1/SLC1A3 NRZP-0622-ZP319 Human Poly WB, IHC EAAT2/GLT1 NRZP-0622-ZP320 Human; Mouse; Rat Poly WB, ICC, IHC, FC, IV NRZP-0622-ZP321 Human Mono WB, IHC, ELISA Galectin-3 NRZP-0622-ZP322 Human Poly WB, IHC, CyTOF, FC NRZP-0622-ZP323 Mous Poly WB, IHC GAP-43 NRZP-0622-ZP324 Human; Mouse; Rat Poly WB, ICC, IHC NRZP-0622-ZP325 Human; Mouse; Rat Poly WB, ICC, IHC GFAP NRZP-0622-ZP326 Human Mono WB, ICC Glutamine Synthetase NRZP-0622-ZP327 Human; Mouse; Rat Poly WB, IHC NRZP-0622-ZP328 Human; Mouse; Rat Poly WB, ICC, IP HES-1 NRZP-0622-ZP329 Human Mono ICC, IHC NRZP-0622-ZP330 Human Poly WB, IHC NDRG2 NRZP-0622-ZP331 Human; Mouse; Rat Poly WB, IHC, ICC Notch-1 NRZP-0622-ZP332 Mouse; Rat Poly WB, ICC, IHC, Block; Neut, CyTOF, FC NRZP-0622-ZP333 Human; Mouse; Rat Mono WB, ICC, IHC, FC S100B NRZP-0622-ZP334 Human Poly WB, IHC SOX9 NRZP-0622-ZP335 Human Poly WB, ICC NRZP-0622-ZP336 Human; Mouse; Rat Poly WB, ICC, IHC, ChIP, ELISA, FC, IP, SW Survivin NRZP-0622-ZP337 Human Poly WB, IHC 17
Oligodendrocyte Markers Oligodendrocyte Markers Nuclear NKX2.2 Olig2 SOX10 Cytoplasmic Olig2 Cell Surface A2B5 NG2/MCSP Oligodendrocyte Marker O4 PDGFR Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications A2B5 NRZP-0622-ZP338 Human; Mouse; Rat Mono ICC, CyTOF, FC NRZP-0622-ZP339 Human Mono WB, ICC, IHC, FC, IP NG2/MCSP NRZP-0622-ZP340 Human Mono WB, IHC, CyTOF, FC NKX2.2 NRZP-0622-ZP341 Human; Mouse; Rat Mono WB, ICC Olig2 NRZP-0622-ZP342 Human Poly WB, ICC, IHC, ChIP Oligodendrocyte Marker O4 NRZP-0622-ZP343 Human; Mouse; Rat Mono ICC, CyTOF, FC NRZP-0622-ZP344 Human Mono ICC, CyTOF, FC PDGFR NRZP-0622-ZP345 Mous Poly WB, IHC, Block; Neut SOX10 NRZP-0622-ZP346 Human; Rat Mono ICC, IHC Immature Oligodendrocyte Markers Immature Oligodendrocyte Markers *Cytoplasmic(plasma membrane) CNPase Cell Surface Oligodendrocyte Marker O1 Oligodendrocyte Marker O4 *Cytoplasmic marker is found associated with the membrane of the listed cell structure. Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications CNPase NRZP-0622-ZP347 Human; Mouse; Rat Mono WB, IHC Oligodendrocyte Marker O1 NRZP-0622-ZP348 Human; Mouse; Rat Mono ICC, CyTOF, FC Oligodendrocyte Marker O4 NRZP-0622-ZP349 Human; Mouse; Rat Mono ICC, CyTOF, FC Oligodendrocyte Marker O4 was detected in immersion fixed 7 day differentiated rat cortical stem cells using 1 µg/mL Mouse Anti- Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Monoclonal Antibody (Catalog # NRZP-0622- ZP343) for 3 hours at room temperature. Cells were stained (red) and counterstained with DAPI (blue). Oligodendrocyte Marker O1 was detected in immersion fixed 7 day differentiated rat cortical stem cells using Mouse Anti-Human/Mouse/Rat/Chicken Oligodendrocyte Marker O1 Monoclonal Antibody (Catalog # NRZP-0622- ZP348) at 1 µg/mL for 3 hours at room temperature. Cells were stained using the Anti-Mouse IgM Secondary Antibody (red) and counterstained with DAPI (blue). 18
Mature, Non Mature, Non- -Myelinating Oligodendrocyte Markers Myelinating Oligodendrocyte Markers Cytoplasmic APC *Cytoplasmic(plasma membrane) CNPase *Cytoplasmic(endoplasmicreticulum) Nogo-A Cell Surface Oligodendrocyte Marker O1 Oligodendrocyte Marker O4 Myelin PLP Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications APC NRZP-0622-ZP350 Human; Mouse; Rat Poly WB, ICC, IHC CNPase NRZP-0622-ZP351 Human; Mouse; Rat Mono WB, IHC Oligodendrocyte Marker O1 NRZP-0622-ZP352 Human; Mouse; Rat Mono ICC, CyTOF, FC Oligodendrocyte Marker O4 NRZP-0622-ZP353 Human; Mouse; Rat Mono ICC, CyTOF, FC Myelin PLP NRZP-0622-ZP354 Human; Mouse; Rat Poly WB, IHC Nogo-A NRZP-0622-ZP355 Rat Mono IHC Nogo-A (aa 566-748) NRZP-0622-ZP356 Human Poly WB, ICC Mature, Myelinating Oligodendrocyte Markers Mature, Myelinating Oligodendrocyte Markers Cytoplasmic APC TPPP/p25 *Cytoplasmic(plasma membrane) CNPase OMgp *Cytoplasmic(myelin) MBP *Cytoplasmic(endoplasmicreticulum) Nogo-A Cell Surface Caspr2 MAG/Siglec- 4a MOG Myelin PLP *Cytoplasmic marker is found associated with the membrane of the listed cell structure. Marker Marker Catalog # Catalog # Specie Specie Clonality Clonality Applications Applications APC NRZP-0622-ZP357 Human; Mouse; Rat Poly WB, ICC, IHC Caspr2 NRZP-0622-ZP358 Human; Mouse; Rat Poly WB, IHC CNPase NRZP-0622-ZP359 Human; Mouse; Rat Mono WB, IHC MAG/Siglec-4a NRZP-0622-ZP360 Rat Poly WB, IHC NRZP-0622-ZP361 Human; Mouse; Rat Poly WB, ICC, IHC, ELISA MBP NRZP-0622-ZP362 Human; Mouse; Rat Mono WB, ICC NRZP-0622-ZP363 Human Poly WB, IHC MOG NRZP-0622-ZP364 Mous Poly WB, IHC Myelin PLP NRZP-0622-ZP365 Human; Mouse; Rat Poly WB, IHC Nogo-A NRZP-0622-ZP366 Rat Mono IHC Nogo-A (aa 566–748) NRZP-0622-ZP367 Human Poly WB, ICC OMgp NRZP-0622-ZP368 Human; Mouse; Rat Poly WB, IHC TPPP/p25 NRZP-0622-ZP369 Human; Mouse; Rat Poly WB, IHC, ELISA 19
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