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Telaprevir + Peginterferon + Ribavirin for GT1 PROVE1 Study

Learn about Telaprevir, Peginterferon, Ribavirin treatment regimens, results on SVR24, relapse rates, and conclusions from the PROVE1 study for treatment-naïve HCV Genotype 1 patients.

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Telaprevir + Peginterferon + Ribavirin for GT1 PROVE1 Study

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  1. Phase 2b TreatmentNaïve Telaprevir + Peginterferon + Ribavirin for GT1PROVE1 Study McHutchison JG, et. al. N Engl J Med. 2009;360:1827-38.

  2. Telaprevir for Treatment-Naïve HCV Genotype 1PROVE1: Study Feature Drug DosingTelaprevir = 1250 mg on day 1, then 750 mg every 8 hoursPeginterferon alfa-2a = 180 µg weeklyRibavirin = 1000 mg/day for wt < 75 kg; 1200 mg/day for wt > 75 kg Source: McHutchisonJG, et. al. N Engl J Med. 2009;360:1827-38.

  3. Telaprevir for Treatment-Naïve HCV Genotype 1PROVE1 Study: Treatment Regimens Week 0 12 24 48 N=17 T12PR12 Telaprevir PEG + RBV N=79 T12PR24 Telaprevir PEG + RBV T12PR48 N=79 Telaprevir PEG + RBV PR48 N=75 Placebo PEG + RBV Source: McHutchisonJG, et. al. N Engl J Med. 2009;360:1827-38.

  4. Telaprevir for Treatment-Naïve HCV Genotype 1PROVE1 Study: Results PROVE1: SVR24 by Regimen SVR = Sustained Virologic Response; T = Telaprevir; PR = Peginterferon + Ribavirin Source: McHutchisonJG, et. al. N Engl J Med. 2009;360:1827-38.

  5. Telaprevir for Treatment-Naïve HCV Genotype 1PROVE1 Study: Results PROVE1: Percentage of Patients with Relapse by Regimen T = Telaprevir; PR = Peginterferon + Ribavirin Source: McHutchisonJG, et. al. N Engl J Med. 2009;360:1827-38.

  6. Telaprevir for Treatment-Naïve HCV Genotype 1PROVE1 Study: Results PROVE1: Patients with SVR24 and Relapse by Regimen SVR = Sustained Virologic Response; T = Telaprevir; PR = Peginterferon + Ribavirin Source: McHutchisonJG, et. al. N Engl J Med. 2009;360:1827-38.

  7. Telaprevir for Treatment-Naïve HCV Genotype 1PROVE1 Study: Conclusions Source:McHutchisonJG, et. al. N Engl J Med. 2009;360:1827-38.

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